Gordon Stein, CFO of CleanTech Lithium, explains why CTL acquired the 23 Laguna Verde licenses. Watch the video here.
poorly timed director comments, a general market 20% reset all round and nothing to indicate how this now FDA approved kit will be commercialised was the problem.
A whiff of interest from one of the big boys or some timeline for commercialisation and revenues will see a more realistic price point I'm sure. As with many shares a little patience can go a long way.
And I agree - anyone who didn't bank profit on a 60% rise really shouldn't be moaning now.
Ophidian
I think a licensing deal for 3996 is already negotiated and agreed and will be penned when the AVA6000 data is confirmed in RNS. I think the proximity of the Avacta team and the Takeda team means that the preclinical work on 3996 is being closely monitored possibly even co-directed.
If you read the development history of Bortezomib and the Patent cases defended by Takeda and J&J - then it is possible to better understand why 3996 may be being developed as a PreCISION bound analog and why it would be such a valuable (and perhaps even necessary) asset for Takeda especially in the US of course. - Just my speculation I have no inside knowledge of any deal
Ophidian
The problem with doxorubicin in the body is as good as it is at intercalating with Cancer cells and thereby killing them - it's residency time is quite short it is rapidly metabolised into something that kills heart muscle, being systemically available it gets everywhere and kills as many non cancer cells as it does cancer cells (probably more) and it is a nasty poison that kills people.
Find a way to apply it ONLY at the site of the Cancer, stop it becoming systemically available and extend the residency time and..............................
oh wait just a minute !!!!!
Ophidian
Todays share price is a bit of an irrelevance as is tomorrows or last weeks or next weeks. As Dr Smith said at the AGM - big Pharma doesn't try and pick up shares it just waits to see what the platform is worth - then pays the price.
Every day some group if pizza delivery boys spends suppressing the share price or the MMs spend trying to squeeze a little more trading action doesn't matter - if you have the means just see it as opportunity to buy £50 notes under a quid.
One day there will be an RNS saying shares suspended - until then it's just do your research, make your choice and wait patiently.
Everything else is just noise
Ophidian
@D-Geeman unfortunately FAP(a) is upregulated in some types of pulmonary fibrosis. See attached paper:
https://www.sciencedirect.com/science/article/abs/pii/S0046817705006908
(and yes I am sceptical that the AVA6000 molecule can pass the blood brain barrier)
Ophidian
Some centres concentrate on specific Cancer types. In this way the practically "guarantee" a progression of patients into the trial and make comparison and monitoring more straight forward.
Ophidian
Check out : https://avacta.wistia.com/medias/kv40kul5b2
Slide 2 of Alastair Smiths presentation of the New Orleans Poster.
Soft Tissue Sarcoma is just about the highest FAP concentration of any cancer type and Ovarian cancer is a similarly high concentration candidate.
I think this is most likely behind the choice.
Ophdian
@gmcc - at least half the dose is excreted pretty much unchanged inside 4-6 days. of the remaining dose about 25-40% is metabolised to doxorubicinol and goes on to cause problems
you utter fool - nowhere have I claimed to have inside information - I have simply pointed out that someone else quite conceivably may have and that writing them off as you so rapidly do may not be the smartest move
No I am suggesting that being rude to someone who has a reliable history of good calls on the company isn't the smartest course of action and that potentially there is more than one way to know when things are positive - but hey it seems that the in vogue thing to do on practically all lse boards is to shout down and demand the kind of "evidence" that would simply get people sacked btw - how do you KNOW who does and doesn't have information ? FDA do talk to you when you are waiting for them to complete their processes before you actually receive the (usually email) notification of approval - it lets you make plans and for example start the necessary manufacturing steps with longer lead times..........