RE: Onego Bio1 Mar 2025 13:30
I was also curious about how realistic her titer numbers were, here's the quote from the article: “Trichoderma is a fantastic platform because it allows significantly higher production levels compared to other organisms. While 100-120g/l is fully possible, 40-50g/l makes strong business sense. Nobody has done this with ovalbumin before, but the system architecture remains more or less the same regardless of the end product.”
I also wanted to dig a bit deeper into the total size of the egg market, because her $300B number is for the total market, not just egg whites. Here's Grok: "The $300 Billion Egg Market Context
The global egg market is massive—1.2 trillion eggs produced annually, with a value reflecting both consumer (table eggs) and industrial (processed ingredients) demand. Egg whites, as ~60% of an egg’s volume, are a big driver, especially in processed forms (liquid, powder) for baking, protein supplements, and more. My earlier $5 billion was just the egg white powder niche, but the full egg white market (liquid + dried) could easily be $50-100 billion within that $300 billion total, depending on how you slice it. The rest includes whole eggs and yolks, with applications from mayonnaise to pharma.
"Supply Chain is Badly Broken"
The CEO’s diagnosis of a broken egg supply chain is spot-on and amplifies Tr-OVA’s potential. Here’s why she’s likely optimistic:
Volatility: Egg prices swing wildly—avian flu outbreaks in 2022-2023 spiked U.S. prices 50-100% (e.g., $2.50/dozen to $5+), and 2024 saw lingering effects with 10-15 million birds culled. In 2025, ongoing risks (disease, climate impacts on feed) keep supply shaky.
Feed Costs: Feed (corn, soy) accounts for 60-70% of egg production costs. Global supply chain disruptions—Ukraine war, drought—pushed corn prices to $6-$8/bushel in 2023-2024, and while they’ve eased slightly by 2025, they’re still volatile compared to pre-2020 norms.
Regulation: Cage-free mandates (e.g., EU by 2027, California already in effect) raise costs 20-30%—a dozen cage-free eggs might cost $1.20-$1.50 to produce vs. $0.70-$1.00 for conventional. Retail prices reflect this: $3-$5/dozen vs. $2-$3.
Sustainability: Eggs have a high environmental footprint—land, water, and 5-6 kg CO2e/dozen. Consumer and regulatory pressure (e.g., EU Green Deal) favors low-impact alternatives.
Labor and Logistics: Labor shortages and transport costs (fuel up 20% since 2021) strain the chain, especially for perishable eggs.
A "badly broken" supply chain means higher baseline costs (say, $0.06-$0.12/g of egg white protein) and unreliable supply—perfect conditions for a disruptor like Onego Bio.
Tr-OVA at 50-80 g/L Revisited
With the egg market at $300 billion and a fragile supply chain, let’s reassess Tr-OVA competitiveness:
Cost Recap: At 50-80 g/L, I estimated $4.20-$8.30/kg for Tr-OVA powder—$0.0042-$0.0083/g of protein. Chicken egg white powder, at $5-10/kg ($0.005-$0.010/g), is