Member Info for Mumbo_Jumbo

Moment of truth coming up for avacta. Will they finally deliver or will AL throw a dead cat on the table to distract everyone.

Personally can’t see how everything will come together in 3 trading sessions.

Maf - don’t leave. Just ignore.

Xviolet - we will find out soon enough when we start open up. We will not lock down unless hospitalisations start to increase, that is the metric they will hold out for. They have already prepared us for increased infections.

Concur with sentiment. I looked at it when it was in 60s and the huge debt put me off as well as the fact that it only carries them through for another year or so. Another round of lockdowns and you start to wonder how long can they stay afloat with no income.

I am like you, I like being in a share for longer term. If it’s a good share with good product then over time you will make money. It’s a question of patience.

IMM is the only one that tested my patience and I sold out.

Only 1k worth I believe.

Finally balanced!! Been waiting for months, thought it might get delayed :)

We might get a chance to push for the monthly prediction win for once :)

The comparisons are incorrect with Spanish flu. There was no vaccine back then. These vaccine are not like flu one but more like measles with their efficacy. The question is how quickly we can distribute around the globe and get it under control. It’s the lag of this process that will keep the pandemic alive for now. but the end is in sight.

Look at Israel, the economy is now open, infection rate is right down and not escalating. crucially, they are not bothering with wasting money on mass testing with lfd.

Sangijuelas1,

Its a complete waste of time with 4D. Whats happened since? I said it was a terrible idea to make your body mount an immune response to the good bacterial species, its a dangerous thing and that their hardly anything novel in their research. We had the discussion there and you kept jumping from pillar to post avoiding answering my question.

So once again, its very straight forward: Is it a good idea to make your body mount an immune response to good bacterial species in your body?

Connerthedog,

You have it confused, let me clear it up using wuhan and kent versions.

Right now avacta gets takes a molecular biology scissor, cuts the viral dna/rna from the virus, puts that into an optimised bacterial system, which then produces the protein, which is then purified and avacta tech is developed using that.

Now, Kent variant comes along, it has 18 changes in its sequence. It does not matter how many changes it has, we know the entire sequence of the Kent variant. So we take this Kent variant S protein gene sequence and email a DNA synthesis company and ask them to produce it, which you can then use to express in the bacterial system and produce your new protein. Notice what has happened - you did not need to use the moecular biology scissors to cut out the S gene from the virus.

All the variants of concern have mutations that lead to amino acid changes, which is why they are variants of concern. They have changed physical and chemical properties to render the vaccine less effective. Avacta would have had to change the purification process to accommodate the test against Kent variant. Are you saying that Avacta processes are cumbersome that its not easily changed to accommodate new variant protein? I had assumed this part Avacta should be able to do without fuss, but you are suggesting otherwise. If that is the case then that is a real concern for Avacta technology and how quickly it can adapt to changing landscape.

Pic,

The SARs vaccines got panned because it made the secondary infection worse! Its not a fact that gets publicized much.

Pic

You are being unnecessarily defensive and confusing issues. There is development side and then there is testing. They only need the protein to develop the test, how good it is will be found out after testing. What I am saying is that there is no hindrance in design and development, don't need the live virus for it.

VC

Avacta don't need live variants to design new tests. The need purified S protein from the variants, which they can do going via synthetic dna route.

Ofcourse then that needs to be validated against patient samples. And it has to be far more than 56, which is what their test is based on.

Ginge,

Then why make such an ignorant comment about PCR in the opening post? You should know better. It cant find it is because the primers are not designed for the variant, which can be done within hours.

The RNS mentions 2 variants.

As a man of science, you should know that it does not need the whole virus, it just needs the S protein. Since we know the reference sequence and the mutations, we can design the whole S protein with synthetic dna and express and produce it. I went over this topic few weeks ago here. There is no reason why they should not be designing tests for the impending storm.

VC

I called the failed test at porton down on the day of the RNS whilst everyone else was high fiving. I am still not sure how they will achieve Clinial Validation by the 7th. There is lot of obfuscation with Mologic, but fact remains, this test will need to be validated again by the Government and what changes have been made that it passes this time.

I keep saying that we have all the information we need. If the technology is robust, design for the impending need.

Good reminder about Cytiva - whatever happened there?

Clearly you do not understand how pcr works. You do know that you can just change the pcr primer, and it is the most easiest thing to do. We know all the sequences!! It takes matter of hours not even days. What takes time is producing new primers in sufficient quantity and getting it out to everyone.

Again, point to me where in RNS it says it can detect all variants. The answer is it does not. Its only reportedly able to detect two variants thus far.

Pl75

We are in lockdown. The Kent variant is in itself more than one variant. One of which is where it acquired E484K. All these numbers are suppressed due to lockdown.

Take p1 Brazil variant, it’s 2-2.5 times more infectious. It’s only a matter of time before these variants take hold when society opens up. We are about to take Portugal off the list of red zone, which essentially is a back door to travel from Brazil.

Pic - look at it this way, any test/vaccine or therapeutic has to be fit for purpose. If South African variant like mutants become dominant, then any test has to be to detect it, otherwise it would be a waste of time.

Your suggestion is good, we know the constellation of mutations that are dangerous and therefore design the test around those now and get ahead of the game and reap the rewards.

Pic - Israel is going via vaccine. So far so good.

I raised the E484K issue few weeks back and what VC said is correct. To control the pandemic, we need to get ahead of the game and not always play catch up.

AZ vaccine is only 10% efficacious against South African variant...... it’s the reason why SA halted the use of AZ vaccine.

Detection of this variant has to be top priority.