RE: Another reason to hold for next few years.15 Jul 2021 08:28
Thanks Energy - I liked this bit
“The ESAC also briefly discussed new alternative binders that are being introduced in the market, such as aptamers, affimers, DARPINs. These alternative binders can be based on peptides, proteins, ribonucleic acids, or single-stranded DNA. Although these new molecules are already being applied in diagnostics, antibodies are still the molecules of choice for many applications. The ESAC recommended that a more detailed review of such alternative affinity reagents is conducted in the future once more data become available (see Annex 2 - ESAC Working Group report).
Based on the available scientific literature, application examples and the experts’ own extensive experience, the ESAC concluded that non-animal-derived antibodies are mature reagents generated by a proven technology that are not only equivalent to animal-derived antibodies, but in many respects can offer significant scientific advantages and economic benefits (see Annex 1 - ESAC Opinion and Annex 2 – ESAC Working Group report). Non-animal-derived antibodies are well-defined and better reagents that will improve the reproducibility and relevance of scientific procedures and lead to more efficient and effective use of research funds. Animal-derived antibodies typically suffer from batch-to-batch variability and many show low specificity. Such issues can be easily addressed through the use of non-animal-derived antibodies obtained by phage-display technology. Equally, antibodies used for regulatory applications, e.g., reagents used in toxicity tests or for the quality control of biologicals, should be non-animal-derived. This will enhance reproducibility of results and the sustainable supply of reagents”
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