Not quite the "Slough of Despond"18 Apr 2018 09:30
Clearly very disappointing news in that the trial results did not demonstrate a significant & unequivocal benefit over existing Standard of Care. On the other hand i do not think that holders should, as yet, abandon all hope. The data from this study & the open-label extension will need to be mined & studied to further depths. Lupus is a very complex disorder. I am intrigued, as will be others, with the patients who went into complete remission & this subset where the clinical differentiation was most marked. These were, presumably, long-term sufferers & i do not know, not being a clinician, whether such cases of remission are common. Also, it does need to be recognised that placebo did mean existing Standard of Care only & not no care at all. What therefore was this placebo response & would it have continued longer term. These are all questions to be asked & answered over time. Potential partners will do their own exploration of the data & a joint-venture may yet emerge. Time will tell but it may well be that, from here, those holders who do not "throw the baby out with the bathwater" may yet get their reward, even if not quite as gilded as hoped.