Member Info for Harrogate4

Nursesteve -----They have to apply for it.

An excellent point.

Am very much looking forward to next week's "unmissable" seminar on 4th December, and am hopeful that it may initiate an end to the mind numbing tedium that presently grips the SP movement.

Best of luck to all patients and SHs.

BV ------ "but the data isn't properly available to talk about yet."

Thanks ----makes sense.

Anyone know if Avacta are attending this important gathering?

I would have thought this was on the cards but don't remember confirmation ( I might have missed it)

Thanks.

Avacta seem to be on at 4pm on the Thursday 4th and Victoria Juskaite, Principal Scientist Therapeutics will be presenting for Avacta.

Her contribution will be as follows:

Optimising Spheroid Co-Cultures & PDX models to Empower the

Translation of FAP-Enabled pre|CISION®-Peptide Drug Conjugates

• Highlighting the background of fibroblast activation protein (FAP)-enabled

pre|CISION®-peptide drug conjugates (PDCs) and the rationale for model selection

• Sharing best practices for developing co-cultures of tumour cells and human primary

FAP+ fibroblasts to assess bystander activity of PDCs in physiologically

relevant systems

• Characterising PDCs using CDX, PDX models, and spheroid co-cultures to better

understand their mechanism of action.

Pharma leaders from the likes of AZ,J&J,Roche, Merk and Novartis will be in attendance.

BV ---- The Med Chem Express site says --------"For research use only. We do not sell to patients." when they talk about Faridoxorubicin (AVA6000).

So they sell the stuff to those doing research through MCE's enormously comprehensive distribution network all over the world.

Or are you saying they have no right to do that?

But sadly not sustained, but a good effort.

No luck today but there's always tomorrow ----nearly broke 82p today.

Good luck to all patients and SHs.

On a bad day for the market ( index down 130 plus points at present), AVCT is performing well and making its 3rd attempt to break 82p today.

It had about 5 goes yesterday but didn't quite manage it, but am hoping for a breakthrough later this afternoon with a bit of luck.

Touk -----------? Wait until SGC data available, say 2Q25? Where will the SP be then?

2Q26 I presume you mean?

Aldebaran --------" its a very firm hold for me now and do nothing to maximise profits. Its that simple"

Yes, agree with that 100%.

The SP IS Knock knock knockin on 81s door.

Apologies ----Janet Munro at Novartis

DOberman

Yes, that post from Sean Dent is certainly a great one and seems to me to make such a strong case for Novartis being shortly involved with Avacta in some way as yet unknown.

The clinchers (for me) are the relative cheapness of PDCs v ADCs combined with Novartis's limited involvement with the ADCs, and of course the close following that Janet Monro at Novartis has had with Avacta over the years.

Exciting times ahead.

Had noted that.

Pedro -------"-Yes, that will give the SP a Filet."

Does that come with chips ----or do you mean a fillip ---meaning a boost?

Hurst -----"with a target beyond anything we have seen before and off course breaking 12 mth highs later this afternoon."

Do you mean "of course" or "off course" -----it makes a difference.

Montyfino -----"5% down in aus."

Now only down 2.09% so going in the right direction.

Montyfino -----"5% down in aus."

Now only down 2.09% so going in the right direction.

Is the title of a great article headlining in Times 2 today on pages 4 and 5.

In the long section on Targeted therapies he could be talking about Avacta although no names mentioned:

"The latest treatments are different. As we have discovered more about how cancer cells differ from normal ones. what they need to grow and spread, and how they manage to hide from our immune systems. we have discovered how to hit them hard while leaving the rest of the body largely unscathed."

Well worth a read.