RE: Farty Towels1 Mar 2026 19:52
Vanilla, it's fair to say that for AVA6000/fariDox in SGC, a very challenging disease to treat and one where Dox is chemo-refractive, clear efficacy hasn't been proven. It's also true that the bar is very low and now with the Dox cumulative limit lifted we are going to see a far higher objective rate response.
As a reminder AVA6000 is blowing the progression-free survival metric out of the park , the disease control rate is very high (90%) and we know it's a much kinder therapy with far fewer side effects but the icing on the cake and where it can make a far bigger difference is if the efficacy is right up there too. In this setting the best that's out there sees an ORR of around 20% so if continuing on treatment means many in the stable disease category end up seeing continued tumour shrinkage then SGC wins out in every regard.
The lifting of the limit is huge in a setting where chemo responses are generally modest, short-lived and toxic.