RE: patent : composition and method27 Oct 2021 21:40
A little something I found on Hiberplex. Any scientists that can shed some light on the below extract?
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For patients at risk for the development of hypoxic-ischemic encephalopathy with MOF and coagulopathy, plasma exchange might be beneficial. Plasma exchange has been shown to reverse sepsis-induced MOF and effectively correct coagulopathy by removing cytokines and inflammatory mediators and restoring clotting homeostasis.247 Granted, further clinical studies are needed; however, combining CPB, mild hypothermia, and plasma exchange would provide maximum therapeutic support after cardiopulmonary arrest, and all of these therapies are clinically used in pediatric patients. This concept of “therapeutic hibernation and plasma exchange” (HIBERPLEX) was introduced for recalcitrant shock in the pediatric population.248 This approach could potentially provide neuroprotection, hemodynamic support, and reversal of MOF, thus targeting the major management challenges after prolonged cardiopulmonary arrest.