Member Info for DRB83

AK Gabba

You'll find version 10 on the PROmate 1g test.

Didn't realise we had a PROmate 2g test. Not a s gene target though.

http://www.primerdesign.co.uk/products/10059-promate-covid-19-covid-19-2g-2-gene

Fair point Kaeren and makes sense. That could cover 5 of the 16 which leaves the 11 that we put forward. Will be interested to find out more from the horses mouth next week.

Hillseeker, yes but assumed the SNPsig range would include at least 5 tests so I guess it's safe to say we have no way of knowing exactly what the other 8 tests are and why only 8. We have more than 11 in total. Is it about 16 from memory. What about the new ones. Hiberplex, RESplex ect. Maybe they aren't covid related. Still haven't been RNS'd either so maybe not launched yet.

Also, still awaiting the RNS for the launch of Coprep. So much positive news to come and with so much positive sentiment and from such a low SP base. It is going to be an interesting Monday.

Also Ade, you say you wouldn't want people regretting they didn't sell at £6 insinuating that they won't get the chance again anytime soon. I agree prices don't go up In a straight line and I will indeed expect a brief correction at some point but what you are talking about is TA trading. No one including you knows for certain when and how big that correction will be. I've been in this share long enough to miss being in when this finally rerates to fair value. By the way. £6 is not fair value. It was about 14 months ago. Alot has happened since but the fundamentals here are sound imo.

Best off keeping your opinions to yourself Ade. If it doesn't drop back at £6 and carries on how would you feel about all the PI's that took your advice. Let me guess, wouldn't give 2 whistles. We live and die by our own sword.

Hillseeker, yes correct. We need ncyt to clarify but I suppose they will only do that if the 2g or 3g test do identify the s drop out.

AK Gabba - PROmate counted as 2 tests (one for each machine) so only 8 to go.

2g
3g
HT
Winterplex
LFT
Escapeplex
Antibody

What am I missing?

That is the problem with sequencing. It takes 2 weeks. The first case was picked up from a sample dated Nov 9th. The variant was identified in the 24th. So let's assume that this strain has been passing freely along with the Delta variant around the world. Wouldn't take long really.

As for the rugby. Pretty safe bet to assume Omicron is well bedded into the fabric of the UK society by now. Regards

Hillseeker, thank you and I was aware of the 3g test looking for the s gene. However, it is still not clear whether the mutations in the Omicron s gene would cause the Genesig 2 or 3g test to pick up the drop out. Earlier research found that the Thermofisher test would pick up on the missing 69/70 elements of the s gene where as the Genesig test would still recognise it as the s gene. Very complicated and scientific but at least it gives some food for thought to the ncyt R&D team for the next test.

The SNPsig for the Omicron will be huge if we can develop one next week. Crest of a wave.

Chris2

You predicted the price of iron ore would fall. It went up to 230 down to 80's back to 100's. Prices rise and fall all the time so hardly mystic meg. Also, the short term fundamentals were against iron due to the property market in China and the winter Olympics. Again hardly mystic meg.

You predicted there would be a placement. Pretty sure we all predicted a placement. Albeit, a little higher than 0.85p.

You predicted that market sentiment would be low. Well, I'll give you that one, just.

You predicted that news would not move the share price. News did move the share price. Pretty sure we touched 1.2p off the back of Han**** which from 0.7p is about 70% increase. The placement news brought it back so I'm not giving you that one.

You predicted that Covid would have a bearing on the share price. I am in covid stocks as I think it will be hanging around for a while yet. Covid has and will continue to affect all explorers due to the backlog of assay results from the test centres so again not really a mystic meg prediction.

Sorry but I am not accepting your mystic meg claim.

UFO is primed and ready to move. It may be volatile and it may be a few months from now but I believe the recent placing put a floor under us at 0.7p. In your eyes there are 3000 UFO's out there in the market. You can't see the differences. That's ok. Let's discuss in 18 months.

Agree with some of what Porky says. Sentiment is massively important in any market and I am feeling positive about the next few weeks. Not everyone is as comfortable as Porky with their ncyt knowledge and I for one enjoyed our discussion on 1g, 2g and 3g. I have learnt something today that will make me a better investor/contributor to this board in the future.

GLA

Yes AK. Thanks, I was looking in the wrong column. Fortunately for Thermofisher then they will be inundated with calls next week. Something for our R&D team to crack in with then.

If you think about it. It is a flaw in the Thermofisher test that has given it an edge with the detection of the Omicron. Our test us more superior and picks up all the gene mutations of Omicron. So our superiority has gone against us slightly on this occasion.

Just think, if the next variant has a drop out of the M gene then bring on the Genesig 3g.

I think you're right. Both the Genesig and PROmate products currently approved are only 1 gene which will both detect the Omicron variation.

I can't see the Thermofisher test on the approval list. All the more reason to get a SNPsig test confirmed to detect Omicron. Watch this space

The £49m has already been removed from the accounts hence the loss in H1. We have already heavily provided for a negative outcome so anything better than 25:75 (in favour of DHSC) and we're quids in.

Given all the positive sentiment at the moment your attempt to bring focus back to the dispute could be conceived as a deramp. Please tell me you're not short. Please

Identifies s gene failures.

Our SNPsig technology provides an alternative to sequencing as well as S gene target failure (SGTF) that enables scientists to analyse and monitor these specific genomic mutations. Our kits can provide a pivotal role in screening for SARS-CoV-2 variants for the purpose of genomic surveillance and studies.

https://www.primerdesign.co.uk/products-hub/snpsig-sars-cov-2-voc-identification-kits

From said WHO document:

Testing and sequencing
Genomic surveillance is of crucial importance for early detection of the presence and monitoring of epidemiological
trends of specific VOCs, VOIs and variants under monitoring, and will provide important information to guide
response for this new variant [16]. This includes regular testing of representative samples but also strengthening
targeted sampling from persons coming from high-risk areas.

The presence of the deletion ?69-70 means that S-gene target failure (SGTF) for the Thermo Fischer TaqPath
assay can be used as a screening method for Omicron. In a setting with the Delta variant dominating, this can be
used as a proxy for Omicron after confirmation of a subset of samples by sequencing. Currently there is no further
information available on any effect on sensitivity for other RT-PCR assays or for rapid antigen tests. Countries
could consider retrospective SGTF screening of SARS-CoV-2 positive samples from recently returned travellers from
Southern African countries to rapidly assess whether cases may have been recently introduced.
Rapid antigen tests should be unaffected based on the analysis of the mutations in the nucleocapsid (N gene) of
Omicron viruses, however, verification of this is underway [13].

It could also be a reasonable assumption that given the number of mutations in the Omicron variant, at least one of those mutations would cause a s gene drop out.

As I said before, an RNS on Monday clarifying this would be great.

If it isn't coincidence that the Genesig test got approved Friday then that would indicate that the test does identify the s gene drop out. I'm clutching here so really need ncyt to update us.

PROmate is a no as only detects ORF1 gene.

PROmate™ COVID-19(Primerdesign Ltd) is direct qRT-PCR workflow solution that
detects a single ORF1ab region

However, we know Genesig both 2g and 3g do detect the s gene so I am assuming like the Thermofisher test it will also not be able to detect the s gene mutations of the Omicron variant thereby inadvertently detecting the Omicron variant. It would be really great if ncyt could clarify this.

Also, when a s gene drop out is recorded then the sample is sent to the lab for sequencing. This can take several days. If like in the past with Delta Ncyt come out and RNS a SNPsig that can confirm the Omicron variant then again Kaboom.

Got a feeling we are going to be inundated with news in December.

Thanks Parkez.

So I'm thinking there are several multi-gene tests out there that could help identify the Omicron. However, it would be fair to assume that not all the 50+ tests on the current approval list will be able to. I would expect that the multi-gene tests will now be prioritised but even so, the demand for Genesig is about to go kaboom.

It is a shame that she only comes out to play on red days. Glory seeker lol

It's not just the approved list that can sell. There are also around 50 tests on the temporary approved list including our PROmate tests that can sell also so we will have a percentage of this 500k daily tests but given the revenue outlook of £7m per month by ncyt I suspect it is a very miniscule percentage. That could all be about to change though.