Member Info for DonaldTrumpsWig

I'm not sure I'm a fan of the 'waffleomat' bolt-on to Hurstbots operating system

I'm delighted to see the SP up 12p on the day, however I caution that we have been here before with unsubstantiated spikes based on nothing.

Nothing has changed from the wet Wednesday 2 days ago when the SP continued its 4p daily slide to sub £1.30

The fundamentals remain rock solid and news is getting closer and closer

Basically WYN, it is just a small number of rainbow chasers playing Avacta hokey cokey whilst we await news.

As has been said numerous times, the results, and how good they are will be the catalyst for any number of scenarios, all of which are very likely to drive the SP upwards.

It's a great time to be a fully loaded LTH, sitting back patiently awaiting the fireworks

'Please make them stop. It’s this unfounded nonsensical drivel that really tees me off.'

Oh the irony

loving the new 'engage with critics' upgrade hurstbot. looking forward to the 'stop talking ****e' module.

JT & PL nailed it IMO. One element of the trial is reliant on FDA approval, C7 on the other hand is within AVCTs control. Might be run in parallel, might not?

BV suggesting Al is pulling the wool and being dishonest, utter nonsense.

Has he been ? Has he been ?

'There are numerous trials in various stages trying to solve the same problem'

But its not the same problem is it? Its a completely different method of addressing a very different cancer.

'Abuse followed with lots of recs.(so its not just the poster)'

No abuse followed, you were just asked to provide specific risks to the AVA6k trial. You couldn't then and you can't now. The trial you have highlighted is a radiotherapy trial for rectal cancer. In scientific terms it's the equivalent of comparing AVA6k with Wilko's

Interesting article and a stark reminder that should the P1a/b results be as positive as we expect then the stars really are beginning to align for AVCT and its shareholders.

1. The TAM for cancer drugs is growing exponentially

2. BP have a well documented track record for purchasing innovative drugs/solutions

3. BP have circa $1.2 trillion at their disposal to fund acquisitions

Should Pre/Cision demonstrate efficacy in a broader cohort sample (safety and tolerability already proven) then plain common sense would suggest that there can be no sensible reason why BP wouldn't be interested in acquiring the platform.

Fascinating times

Exactly Tim, what I think we'd all be interested in is, for example, someone posting a link to a novel drug trial from a company that is using FAPa to target solid tumours.

Not, I wish Al would hurry up because if he doesn't someone might come along and steal his lunch.

Jeeez WYN this needn't be so difficult. I was responding to BV's post asking for thoughts on what are the risks to the chances of AVA's success (see thread title).

I was asking if anyone had any examples of specific risks as whilst I don't disagree that they may exist, I wasn't aware of any examples... and then you pile in with a load of guff about what might happen or what could happen etc etc clogging up the discussion as per.

WYN, with the greatest respect, you have typed out a 3 paragraph response that adds nothing to the question of specific risk.

Yes, we can all suppose that there might be substitutes, we'd all be reassured to see more data from more patients. There could well be a new approach from a new competitor on the horizon...and so on ....but this is all supposition and nothing more than guesswork.

As far as I am aware neither you nor anyone else is capable of providing a specific example and this is what I'm looking for and something that we could all debate.

It's a good question BV and something I'm interested to understand. Just what are the risks ? It's a long time since I studied Economics but a classic economic theory applied to risk was something called Porters 5 forces.

Threat of new entrants, Bargaining power of buyers, Bargaining power of suppliers, Threat of substitutes, and Competitive rivalry.

With the exception of bargaining power of suppliers (of which I have no understanding), I would say AVCT are in a very strong position on the other 4 metrics.

We hear the tired old line that 'all drug trials are risky' without that statement ever being backed up with risk that is specific to AVA/Pre/Cision

I don't have a problem with accepting risk and I am keen to understand where it exists but from my own research:

1. Safety & Tolerability - already confirmed , we are into C7 and no MTD has been found, that in itself is unequivocal.

2. Efficacy - excellent early indications and whilst we can all agree that we need more data, we do know what dox does and that it is being delivered to the TME at 'therapeutic levels'. I can't see any risk in dox delivering its well understood efficacy when delivered to the appropriate tumour types in increased doses.

3. Finance - 'we don't need to worry about that' and the expedited P2 trial has shortened the runway. Absolutely no evidence to suggest that finance is a short/mid term risk.

4. Porters 5 forces - no obvious Substitutes or Alternatives or New Entrants hence reduced bargaining power for buyers

Can anyone think of any other realistic risks? that don't involve arthritis & potash or comparisons to Wilko's?

WYN said 'the penny may have dropped that there are many alternatives being developed with varying degrees of success.'

Care to share any examples of the many alternatives being developed?

Not sure what this has to do with Nasdaq and how the the fact that Verve are listed on Nasdaq has any bearing on this story.

Likewise, this article refers to the trial of a novel therapeutic and I consider myself a Lucky Man (see what I did there) that I am invested in a company that is trialling a delivery mechanism for a decades old drug which as a consequence is protected from the vast majority of risks associated with novel drug development

Sealion ALERT ! another p1ss poor attempt to elicit attention..ignore

In the current news vacuum whilst we await the 21st, I'm getting to the stage where I'd settle for an update on anything:

BAMS & Elisa

Can the LFT now detect Omicron?

Are the lights still on at AVCT?

I'd even consider a charting update from WYN or a condescending lecture from Ophidian. I'm even beginning to wonder if Terry and Viking are OK?

From memory, didn't Al say that they now didn't expect to find a MTD ? and if that isn't a pointer to the incredible specificity of Pre/Cision then I don't know what is?

Good answer Tim to a post that was 100% a pathetic attempt at clickbait/sealioning to attract attention to a desperate narcissist

Please all ignore.