Member Info for Doc.Daneeka

Ok - I'm back onboard and all in. It's a multi-virus trial to prove broad spectrum against every respiratory admission. I'd have prefered just the one big fast effort to pursue an EUA for Covid in hospitals - and would have helped pay for it - but hell - Covid will be included in the the megathon somewhere so we'll still get that and all the others. If we're going to win we might as well win huge.

I do remember, but given that the free trials available are for C19 and LC, and the drugs already enrolled on these are Protease inhibitors which have been chosen because of their performance in viral clearance, it's valid to look at SNG's data in this regard. Only relevant for the few of us who still hope for STRIVE as the best and only way forward and see the multi-virus focus as a pipe dream that can only be realised with the surrender of the company. Nobody is going to fund a £40-50m + trial for a company with an mcap of £21m without taking it all

Why woulde i do that Fruits - you posted it 7 hours ago. My subsequent question was about viral clearance from the Covid trials - which is what will principally determine our place on a Covid or Long Covid platform trial. I answered that myself

Can't see any Viral clearance data for either of the Covid trials - seems like an easy thing to monitor and have data for so surprising it's not there, but then they didn't take blood samples for Sprinter either so maybe not so easy to do with an international trial. The fact that SNG works in both settings implies viral clearance I guess and the COPD vc should play across as a general marker. Shame they didn't analyse the COPD data before Sprinter was designed (which they could have done) as they might have made it one of the priorities if they'd known

Paxlovid is not and never has been a mass market drug. The recent attempt to broaden its authorisation into hospitals failed but it's now the only effective drug for the majority of people who will become seriously ill and die from Covid. This is where we are now. Vax and Pax - and thankfully both are holding up well.
If SNG is ever authorised it will be prescribed in a similar limited fashion to the same population.

Definitely relevant.
It's why Shionogi is the first drug on STRIVE and why Paxlovid is the first drug on RECOVER

It was described as a hypothetical they wanted to explore in the STRIVE launch release from NIH - and this data will reassure them trial designers that they're on the right track
"Findings from the ACTIV-3 trials, which evaluated therapeutics for adults hospitalized with COVID-19, indicated that ongoing viral replication may play a role in driving disease progression to critical illness. The research team hypothesized that a significant number of patients hospitalized with COVID-19 may still benefit from antiviral therapy."

The first line of the STRIVE protocol repeats this
"Treatments are needed to improve outcomes among patients hospitalized for COVID-19, including direct-acting antiviral (DAA) agents to mitigate the pathology driven by ongoing viral replication. "

Viral clearance is the name of the game and the protease inhibitors - so far at least - are still working fine against Omicron I don't know what the viral clearance data is for SNG - perhaps someone else can reply with an answer if they know the data.

On Paxlo - Fruits - Americans are not being given it without a positive test - they just don't need to provide proof of it now - which is the same real world change they made in the Uk to make sure patients get the drug in the narrow window between symptoms and prescription. Highly unlikely that perfectly well individuals without Covid in the most drug suspicious country on earth might start asking for it just for the craic.
There's also little validity in the notion that NIH is trying to use up its stockpile. It has deleted approved therapeutics several times already with no consideration of the huge cost already invested in them.
You're keen to draw attention to the list of conflicting drug interactions - but make no mention of the fact that Paxlovid is specifically efficacious for immuno compromised patients - particularly those who cannot have vaccines. ( 90% reduction in hospitalisations and death in this group ) I trust the NHS to make certain there are no contra-indications before sending out the pills (having witnessed the process personally) - not so certain that MDs in the US are as scrupulous - but I'd imagine they are as observant of the hypocratic oath as our own docs.

The main point is that if SNG has good viral clearance data then it will be a candidate from both platforms, but chucking ill-informed mud at what is the last option for many people does not advance the SNG case one iota

"As TW has been leading so much of the companies work over the last years, I think it's fair to say this recognition from NIHR is very noteworthy. "
It's not remotely noteworthy in terms of Bebold's question aboiut reinvesting. . A nice recognition of TW's pre-eminence but it has nothing to do with the company's current situation. And to be fair it's hardly an exclusive club with 200 members.

Bebold if you have been keeping across the company's RNSes you'll know they have been very busy since Sprinter's failure - harvesting good data from Activ 2 / the Sprinter deep dive as well as a long overdue analysis of the COPD data that was promising. They've presented this information at a variety of important symposia and RM announced via Linkedin in January that the company is pursuing what would be a unique multi virus Respiratory trial to prove SNG as a broad spectrum theraapeutic. We await substantive news with some still hoping for a place on the dalayed STRIVE and others believing some kind of JV to realise the New Years' ambion is more likely. In the absence of this news the sp is almost at an all-time low and will undoubtedly continue to trend downwards.

you don't want to be predicting 8p Ghia - that's bad form. Just say toodaloo and push off

Fruits timeline is still that we could get a major announcement at any time- which is the timeline we all have and the only valid one.
Anyone checking out now is making a calculated gamble that we are not suddenly announced on STRIVE, or even taken over. These are the only scenarios in which players looking on might be embarrassed.
If we get some kind of JV, there will be plenty of time to climb aboard again. With RNS's required to signal every step and a lengthy period of trial design etc during which the sp will be largely unmoved. If STRIVE happens though it will happen instantly and the bump in the sp will be significant - 5, 6 or 10 times the current sp significant. We have no solid info on the next candidate timeline but we know it will be a more complicated protocol than Shionogi. Anyone basing their assessment on the next candidate announcement on the reported replies by Stacey Adam to Org - is taking a very big gamble.

If we are waiting for UNIVERSAL to produce a signal that validates the next trial then we must prepare ourselves for a very long wait. The trial has already had 2 changes in expected recruitment completion from the original 30/6/23 to 30/8/23 and now 30/11/23 - showing that recruitment is not progressing as was hoped. The study end date of 1/6/24 has not shifted yet but if there are any further delays it will. With just Southamptton and Ninewells Hospital in Dundee recruiting patients and needing 2000 at stage 1 and 1000 of these to progress to stage 2. We're not waiting for this in any case. Synairgen should know enough about SNG to know how to design the next trial.

none of us expected a quick nod - except Mani maybe, back when she was a believer.
Feel for Veru though - they had meetings with the FDA - before halting the P3 - and were told they had enough to go for an EUA. Now they're told nah - it's not quite what we were looking for, we remain concerned about “unknown influences, or uncertainties.”
Understandably angry response from the CEO. And then a quick backtrack to say - hey yeah, whatever you need.
Interesting parallels with Synairgen. Both had huge spikes on the back of Covid P2s but were trialing other things before C19. Sabizabulin is also trialing for breast and prostate cancer

Blimey Aether - if he's in your bin and my bin and almost everyone with any sense on this board's bin - why post this every single time. People looking in will assume the whole board is a madhouse. Just ignore them all - don't feed them.

two great one-liners tonight Aether. I thought the Mani line was epic but bringing Lord of the Flies to the table is genius.
I'm Ralph by the way. Tommy is Jack and Mani is Piggy (Miss)

I refrained from using the phrase Happy Clappy a while ago - when i suggested we should all change our language a little for the sake of harmony. You won't find it in any of my posts since then.
I'm a fan of most of your contributions - but you have an agenda that accounts for a lot of the science but ignores the obvious non science realities, and it's more transparent than all of the people you make accusations against.

It's not balance. It's as suspiciopusly one-sided as the ranting of Mc or Ab4. And the endless cheap shots against solid members of this bb who dare to offer a counter view.
There are days when Td posts every single time someone says something negative. A day last week when he was at his desk at 7.18 and rose from it at 22.43. Every single line of contention countered immediately. A double shift of positivity and ramptastic glory.

My question is to Fruits. Who are your bad cops and good cops. and which members comprise your Thought Police ?
Clearly Td has long since identified TP - who actually said that the company had achieved nothing SUBSTANTIVE for a year - which is palpably true as a force for evil - when the rest of us applaud his erudition and balance.

The last group are the ones that cause the constant daily discord. The ADVFN crowd - emboldened by the continued lack of news to venture into the light and finding that LSE can also be turned into a charnel house. Halfwits most of them - demonstrably so by their poor grasp of grammar and witless assaults - but dangerous and ugly
Ab4 is the High Priest of this cabal. Rantingly relentless in his/her assault on everything SNG. Motivelessly malignant and articulate in the deranged way that Hitler could hold a crowd in his spell. Psychotically pursuing some stange personal animus against the world. Be in no doubt Ab4's antagonism to this bb is not singular. He will be engaged in vicious battles across social media with dozens and hudreds of faceless adversaries.
Beneath him a motley crew of scu.mbags and pederasts - here to do what exactly ? To trade ? Maybe ? To abuse the company that they still can't walk away from ? Certainly. Whatever their intent they are evil and transparent.
These troglodytes occupy the darkest realms of this board and are encouraged - by engagement and reply - to return day after day. They will be with us - like Covid - forever. It's your choice if you keep their thread titles alive.

Fruits you need to come clean. Who are the good cops and bad cops in your "routine" and who is the Thought Police visitor who arrives every week. You and Tommy clearly suspect The Paladin of occupying one of these roles - I'd guess you suspect Trinity as well. I can make a case for either as the "good cop" but who on earth are the other characters in your little play ?
Most of us can see there are several loosely arranged groups on here.
You belong to the "never a bad word about the company or the current situation - except if it relates to other therapeutics or the prospect of an imminent meltdown with the latest variant" group. FruitsnVoc I almost called you once. ! Tommyd and Brand are with you in this dwindling band of believers and from the upticks you all receive, still quite a few others who only declare themselves in their recommendations. You care the flame for Reddit - where many clever cold brains are still indefatigably optimistic.
Yours is the high ground - refusing to allow the increasing noise to distract you and never taking a backward step. It's still Feb 20th in your world and your positivity is essential to holding a line between what happens here and the shambles of ADVFN.
In the middle sits a growing band of skeptical but solid shareholders. Happy to stand on their chairs for all the little bits of confirmatory science and decent pr - but rarely inclined to throw their hats in the air anymore and increasingly concerned that 12+ months of nothing substantive is becoming ever so slightly wearing. In this middle strata sit players like TP, TM, Doc83 ( altho he's generally more chipper than this and too polite to ever be directly critical) Wigster -tellingly the second of our AGM reporters - and also much too well bred to join the rabble- might also be classed as a member of this broad group as are many other occasional contributors who pop up from time to time with a less than positive shot across the bows.
Then there''s the bizarre group of shareholders who bore us to death with their running battles with just one other poster. Feuds that have lasted longer than Omicron and flare up at the sight of a name or what they perceive as a game ending faux pas. HA !! did you really just say this - when on 17th June 2021 you also said THIS !!!
These posters are usually perfectly sound away from their specific petty battles - and many of us have been in short bloody spats at one time or another but managed to wake up the next day and move on.
Before we come to the bottom feeders there is also probably a small group of the terminally stupid. These fine citizens bounced along with the crowd when the sp was going gangbusters and it seemed we'd all be millionaires in a day or two - but instead of melting away when the crash came - of course they're still stuck with their shares and still offering up their moronic world view. I might have a place in this group I suppose. I'm stupid and stuck anyway.

Ok thanks for clarifying Fruits. The job ad for Synairgen is nothing to do with the company. They didn't send the job description to Hobson Prior but encouraged them to cut and paste from another similar job ad. And nobody from Synairgen or Hobson Prior looked at it before it was advertised as it's only a lab tech. Brilliant.

Manor/manner is a shocking mistake. Maybe they should get the science writer to proof the ads

You should look in more often HSD - it's been on here since 15th Feb.

( NIH has an update service and will send you all their news releases if you request it. You do get a lot though and learn more than you might wish about all sorts of unpleasant conditions. Worth it for the happy day that SNG is announced as the 2nd or 3rd candidate )