Member Info for Doc.Daneeka

Really sorry to hear of your diagnosis Trinity, but certain you and Td will sail through. I'm imagining you both sitting next to each other in the high backed chairs with blankets round your shoulders and Philipino nurses checking the IVs carrying the elixir into your veins. Tommy searching for Ifn studies on his iphone and you composing something thoughtful in your head as you both sit there and the good juice flows.

We're all fans of the same struggling team - some of us see only the mishaps and want the manager sacked - others see something glinting in the distance. But we support the same team and each other and when the net bulges everything is forgotten as our feet leave the ground and we surge down the terrace.

"A friend in Germany tells me everyone's stockpiling sausage and cheese ... It's the wurst käse scenario. "

Two years ago today - from my FB. When the pandemic was at its global peak and taking 1000s every day, mostly in unvaxed and un-exposed China - but we were a year past our wurst and cracking funnies.

Like German wine - it hasn't aged well.

I'm sure topping up is a good idea Aether. If i had more spare I'd be doing it. But as a trader, not for the long term. Synairgen can't finish this story on their own and the question is not if - but when the partner comes on board. They won't try a cash raise but they will surrender equity to stay solvent until the P2s are complete. If J&J or AZ come onboard before the P2s start there will be a bounce. If the science behind the protocols is really convincing - which it really must be - there'll be a bounce but other wise the market won't care particuarly that the P2s are underway and there will just be a long worrying wait until they complete - with Mani reminding us every week how much is left in petty cash.

So I'd top up on the basis that the market will like the Clabs assays and rationales - or one of our suitors turns up with a bunch of roses.

Perfectly happy with the reality of the situation Fruits. The money went 2 years ago - if some of it comes back that'll be a welcome miracle. If it takes a while because they finally realised SNG001 is not a mass population Covid blockbuster that's fine. Particularly happy to hear that you'll no longer be scouring the globe for new C19 mutations, and will look forward to reading your scholarly musings on RSV and Asthma and Flu and all the other things we don't have data for, but are now in the business of. You've earned the rest from your morbid Covid watch. Enjoy.

Well you're a miserable pair of fearmongers aren't you. How about joining me in a toast to the vaxes and mabs and protease inhibitors and dexa and remdes and to community immunity and the resilience of the global immune system - but mostly to the weakening virus that has given us such a beautiful moment - when we can say that we have just 1% of deaths compared to exactly 2 years ago ?

The death rate is actually 1% of the peak of global deaths from Covid. If Td wants to dredge up the WHO's Covid lead to tell us that waste water is still swarming with it and it's rampant - then where are the deaths ? Show me the bodies. We've passed the winter peak according to most analysts. The only answer is that JN.1 is not deadly to almost everyone in the whole world - unless unvaxed or severely compromised.

Inarguable - irrefutable and obviously to the T&F - if not yet G - utterly indigestible. It's good news to everyone on the planet except those who se lips curl and eyes swivel when anyone interrupts their doomsday chant

Certainly not gone away - and probably never will - but year on year, infections, hospitalisations and deaths continue to fall dramatically to the point where Covid 19 is a short paragraph on page 14 and hardly ever impacts our daily lives in the way that it once did.

The peak of deaths came between Nov '20 and Feb '22. 27 months in which the global daily deathometer hovered around 10k - with 4 main peaks of 16k, 15k, 14k and 13k. Every day. This last peak -reached ironically on 8th Feb '22 just before Sprinter's TLR landed - was the last serious surge before deaths dropped like a stone to 1500 by early May 2022, with Omicron - & vaccinations the principal causes. Since then they've dropped further and further into the low hundreds as we know.

Fast forward from that peak to Feb 27th 2024, when the most recent daily toll for the whole planet shows a figure of 186 deaths. 186. .... Just 186.

186 is a little over 1% of 17k - so if the WHO's covid lead is correct about continued virus spread - Tommoclarke is also - palpably, indisputably, and irrefutably correct.

That the potential for disaster remains is without question, but almost 2 years to the day of the pandemic's worst day and still in the northern hemisphere winter - deaths are running at just 1% of that terrible moment.

So yes - we do believe the world's leading scientists, but we can also read a graph and believe the evidence of our eyes.

https://www.worldometers.info/coronavirus/

It's all maths Joey.

Wpa5 I'm giving it back for the constant hectoring and accusations of factual inaccuracies I receive from these 2 posters.

More than happpy to let everyone - including myself - make mistakes - but not to post falsehoods. Opening your post with a stat of 40% in ICU instead of 13% is hardly a typo. Stating that everyone in the States pays for vaccines - when it's your main point - is not a minor slip. I've made 2 constructive and well researched post in the last 2 days - as well as answering Trinityman's excellent post. Find fault with them by all means but make sure you are correct and not engaging in trivial point scoring.

As I said to Fruits earlier - he can stay off my posts unless he wants to add something constructive. If he wants to cavil and hector he'd better make sure he's not telling porkies.

But I will leave it here. Nothing either Fruits or Td has said has enlightened anyone further in relation to these posts - they've just been throwing mud even though the post about US hospitalisations is tremendously supportive of Synairgen's raison d'etre

But vaccines are still free Fruits - which you said they weren't. You pick me up constantly for inaccuracies and yet here you are - at it again.

" Americans now have to pay out of pocket for vaccinations and it's not a cheap recurring expense for the majority of whom live paycheck to paycheck. "

It's already bad enough anyway so why not be accurate. Only 54% of the uninsured ( 29m in the US ) took up the offer when Covid was knocking them over like ninepins. Less of them will get it if they have to get a bus to the other side of town to the one dispensary offering it for free.

Agreed the article doesn't dive too deeply into underlying reasons for low Vax percentages - but even though PHE has ended Americans are not paying personally for vaccines. They're either included in health insurance or available in other ways for the uninsured. When they were free only 54% of uninsured took up the offer - compared to 75% in the general population. We know this is for a variety of societal reasons and can assume the gap will widen as it becomes more difficult to find a free jab .

https://www.hhs.gov/coronavirus/covid-19-care-uninsured-individuals/index.html

This is a really useful piece - which confirms that Synairgen's place must be in the hospital - which we've known since ACTIV2 was halted, and that when it gets there , there will always be a ready supply of patients. Whatever happens with outpatient therapeutics - Covid wards and ICU will still fill up with new patients every time there's a seasonal peak or new variant.

The 1500 figure comes from the December 9th weekly rate - 3 weeks before the final peak of 2,500 deaths. It talks about the need for an updated vaccine based on JN.1 ( and not XBB ) - but it's clear that the main cause is not enough people getting vaccinated and fewer still accessing the available therapeutics.

" As of Jan. 5, just 19.4% of adults aged 18 and older and 8% of children have received the updated COVID vaccine, CDC data shows. Additionally, just 38% of adults aged 65 and older, who are at higher risk of severe illness, have been vaccinated. "

If people are too stupid or complacement or suspicious or so disadvanteged societally that they cannot be convinced of the importance of getting boosted and vaccinated, and if when they become infected they don't access the therapeutics available ( for all the same reasons as vaccine reluctance - plus the added problem of GPs noit understanding the efficacy of Paxlovid in particular ) then the gurneys will continue to trundle through the doors and only in hospital treatments will save them. If 62% of the most vulnerable don't open the letter inviting them for their vaccine or booster, then you're in a world of pain.

It's a convincing argument for SNG - if it completes its trials successfully. As Trinity said yesterday at the start of this discussion saving the lives of these unfortunate or reckless patients may become less important than saving the health service the billions spent on hospitalisation. It's why the magic pill has been the holy grail since Dexa made its dramatic appearance just before Magic Monday. These people are always going to end up in hospital and they're always going to die unless something else is waiting for them before ICU. Hopefully SNG will be there.

https://abcnews.go.com/Health/1500-americans-dying-covid-week/story?id=106237143

I guess that's as close as we'll get to an apology - many thanks Tommy.

Find someone else's post to jump on Fruits and we'll do fine. Nothing in my original post required your attention. It was neutral, factual and accurate. I'll continue to post about any and every Covid therapeutic that has saved lives and will hopefully go on to save more.

I have a fixation with your untruths Fruits. The scaremongering and constant doomsdaying. All of the posts still visible - still warning of imminent catastrophe or cautioning against any tiny sliver of good news that might arrive.

Can you imagine anything as obscene as the poster whose denial default is set so high that he refutes the early evidence coming from South African hospitals that a new fast spreading variant called Omicron - might not be as deadly as previous strains !! That someone would dispute the word of drs and healthcare chiefs and early epedemiology that the new Covid seemed to be much more infectious but could also be a little less severe & might be about to give the world a break. Imagine someone doing that..... just to promote their little parcel of shares in a tiny University spin-off.

Td " The interesting and somewhat scary read from this is most people are now vaccinated to some degree and yet a 40% increase in ICU....

You're cheating again Tommy. " Your own figures show 40% increase in hospitalisations but just 13% in ICU.

Maybe ask the mods to take it down tomorrow in case anyone thinks you're trying to mislead the board.

Here's the latest graph by the way. Infections down - ICU down - Admissions down - Deaths down. Expect that to keep falling as winter ends. As it did last year, and will do next year.

https://covid.cdc.gov/covid-data-tracker/#datatracker-home

" We also know that Pfizer abandoned its study of less severely acute patients because they couldn’t show a difference compared to placebo " explain this please. With a link to something. If you mean they tried it in the hospital and it didn't work - then so did half the trialed drugs for Covid try in more than one setting and fail before trying elsewhere. It's the process. You could say the same about SNG in the outpatient setting. It worked but nowhere near well enough to merit further investigation against a weakining virus. From memory Remdesevir is the only drug authorised in both realms.

Restrospective real world studies - when all of the limitations are acknowledged - as they are very well in this case - are self -evidently the absolute best measure of a drug's performance. A 45k trial population with 5k taking Paxlovid. 3 people in the Paxlo cohort hospitalised.

Tommy and Fruits aren't convinced. They see anomalies, inconsistencies, drug interaction problems. They saw them 2 years ago and said it would all end in years with mutant strains and 3 eyed babies. But in the real world 20m doses have been paid for by the US Govt, and a new mathematical study says Paxlo could have saved up to £170B in hospitalisation costs in the first year of Omicron and a minimum of 30k lives.

" A 2023 National Institutes of Health study found that only about 15% of high-risk patients take Paxlovid when infected with COVID-19. Using a multiscale mathematical model based on conditions seen over 300 days beginning in January 2022, the researchers found that using Paxlovid on 20% of symptomatic COVID-19 patients during the omicron wave would have resulted in up to 850,000 fewer hospitalizations and saved up to $170 billion. Even with lower transmission levels of the virus, the researchers estimate that an expanded use of Paxlovid could save approximately 30,000 lives during an outbreak. "

Night boys. I won't return to this. Useful I hope for anyone who might have an elderly or vulnerable parent or friend to know that it's a dificult process to get Paxlovid - your GP almost certainly won't know anything about it - but if they meet the criteria they might be abloe to get it.

Kinda knew the attack dogs would come snifffing when i posted about Paxlovid - but remember Tommy and Fruits don't care about actual human lives - just whether the tide runs high or low for SNG - and they see everything else - Remdesevir - Dexa - Mol - all the deleted mabs that saved lives - even the frikken vaccines - as the enemy. The only thing they like is the possibility of a new deadly strain that might kill enough people to promote old SNG. It's perverse really. Presenting yourself as one thing when you're the opposite

Such a pettifogging response Fruits. Really disappointing but characteristic of your recent contributions. If you can only skim scan my posts line by line looking for a technical fail and not responding at all to the main argument you might as well let it pass you by entirely or filter me. Read it again and offer something more please - or keep schtum.

If you hadn't been in such a rush to counter my entirely factual and neutral post about Paxlovid's new trial evidence, and so pleased with yourself in finding a report published yesterday !! you might have paused to check the name at the top of the page and saved yourself considerable embarrassment. But it was another Gotcha - and those moments are not to be passed up. I've always posted about everything else going on in the covid sphere and with our competitors and you've always taken these posts as an affront to the majesty of SNG.

JN.1 is on the retreat everywhere by the way. Flu proving slightly more difficult this year - but your quarterly phrophecy of doom has once again been shown to be scaremongering guff.

Not misleading in the slightest. But yes absolutely moot - as i said myself. Trinity was offerring up cost comparisons with outpatient treatments and the most expensive of those described was less than £500 per course - whilst the figure we've always had for SNG is £3500. He was not talking about SNG in the outpatient setting per se but he did compare us to the "low cost" dexa and was right to. Cost is always relevant in or out of hospital, and it's been an obsession on both sides of the pond since the pandemic began.

Thanks Aether - this was a year ago and she's been very well ever since. :)

Very interesting research and analysis Trinity. Too late for me now - but I'm sure others will have something to say and I'll just say that the Paxlovid window is actually 5 days and it was very carefully prescribed for my 88 year old mum with long conversations from the special clinic that authorises it here - before being couriered to her. She had a sore mouth - and one of the other side effects that you don't ask elderly ladies aboout, but that husbands may disclose. Obviously the main "side effect " we noticed about Paxlovid was that my mum - 3 months after finishing chemo - survived her bout with Covid 19. That was the one I was hoping for.

Ensitrelvir would have been EUA'd in the US already I'm sure if Omicron hadn't been judged - and subsequently shown - to be much less dangerous.

And we've known for a long while that early use of Dexa is futile and may even be dangerous. But it cost pennies and in the right cohort at the right time, it saved a lot of lives - "black lung" notwithstanding.

Your points about cost -versus death are well made. We'll be hoping there's still a market for a drug that keeps the wrinklies out of ICU - now that the govt realsies it can't just let them die in their care homes. Our patients will be mostly ancients and our cost effctiveness will be shown in fewer and shorter trips to ICU before they shuffle off. I looked after an old neighbour when we lived in Clapham. He was a naval war veteran and in and out of St Thomas's with his chest. Usually on the ward but often in the high dependency beds when it was bad. He'd have liked SNG001.

It's simple enough. SNG needs to stand up its promising deep dive and viral clearance data and then it will be invited to join the party. Nobody gives a rat's ar.se about the beauty of a natural-ish compound versus bad old DRUGS - all they care about is cost - and of all the outpatient drugs you listed SNG was the most expensive by a factor of at least 7.