Member Info for Doc.Daneeka

Interferonologist ( sic)

There you go again Fruits. Wrong as usual. We all thought interferonologist was funny - and it formed a very large part of the case against Sakura7's credibility - but then you actually look at it and find that on this at least she is entirely correct.

You know where to send your apology old feller.

https://link.springer.com/chapter/10.1007/978-3-7091-3432-0_7

"Cells which encounter a variety of substances called (by interferonologists) “interferon-inducers” begin to produce and release substances which are called (perhaps again only by interferonologists, but maybe other names by investigators of different orientation) “interferons” William E Stewart II The Interferon System

https://www.nejm.org/doi/10.1056/NEJMe1303818

"HCV Treatment — No More Room for Interferonologists? " Joost P.H. Drenth, M.D., Ph.D

https://www.nature.com/articles/287270b0.pdf Correspondence " Interferonology " Lee. H. Kronenberg

CONFIRMATION BIAS

Confirmation bias is the selective search for supportive evidence, defined by the tendency to only find data that supports the desired decision or outcome. This bias can make individuals blind to contrary evidence or cause them to selectively retain information that supports their viewpoint

S7 no, not a physician - monikered for the hapless MD in the novel Catch 22.

Thanks for the in-depth response. We all remember those heady days, when many of us invested more than we should in this share, and were spending the money before we had it. Cars - yachts - houses .... I blame no-one for my own recklessness - but it is true that the few dissenting voices ( and i was one even then on many key issues ) were hammered into silence and driven from the board. We didn't even discuss the possible impacts of SOC on the trials but took it on faith that the company had it factored in - even if the protocols made no allowances for it. Most of the best posters here how have a more cautious - or perhaps resigned - approach to the remaining funds still locked up in SNG. I'd go as far as to say a majority of LTHs still believe in the drug - but have significantly less faith in the company. How could this not be the case, given the disdainful lack of engagement from the BoD and CEO. Only Fruiits and his offensive pal pretend that the company got nothing wrong in Sprinter and have done nothing wrong in the 2 years since.

Last questions from me. Do you think you'll get your 15p back ? And why ? Did you see anything more encouraging in the deep dive for Sprinter or COPD or are you just hoping this will be traded past your average on minor (ish) news.

"I think it’s fair to say you and others spend more time on here than me. My conscience is clear. "

Fruits - Posts 62 ( last 30 days )

TP - Posts 31 ( last 30 days )

Sakura7 please just tell us why you're still here. ? We all have shares and want this to end in success. You have no shares and seem keen for failure. You predicted Sprinter would fail - but on the basis that interferons don't work - which has been disproven by Synairgen and countless other studies. We all understand that the question has never been "does it work" but "how well does it work, and for whom ?" I don't doubt that you are who you say you are - even if others believe you a fraud. It doesn't matter anyway as TP says. It's ridiculous to imagine anyone would concoct such an elababorate backstory for some kind of financial leverage. A fantasist might do it for sure - but not a market making troll.

But the question remains .....If you've never been invested and have already had your moments of vindication and schadenfreude - why are you still posting here. ?

Medication time Fruits

Fair enough Jint - I wasn't defending S7's entire posting history particularly and might have referenced that thread maybe - but I was simply addressing the ludicrous idea proposed by Fruits that S7 is some kind of paid fifth columnist. Or that she appears just before positive news ( I mean - what positive news have we had ? ) Fruits has accused half of us as being agent provocateurs at one time or another and there's really only evidence of a few characters - the most prominent being Andybe4 - that fit this narrative.

God knows who or what Sakura 7 is.

As far as I recall Sakura7 has only posted once before significant news, and that was in late 2021 / early 2022. She was abused then as you are abusing her now. And then Sprinter dropped. We all hope she's wrong - and Synairgen has generated enough data to say that she is - but the idea that some malign force has 'wheeled her out' to generate negativity at sixpence is risible.

I'm gonna tell them to stop your cocoa if you keep nodding off Fruits.

" I have no idea why new investors would want to be 'part' of this company. "

If you were looking at this for the first time with clean eyes, and had done the due diligence, you almost certainly wouldn't invest now, but there'd be a strong asterisk next to SYN for the next RNS which will either set the train back on the tracks or see it trundling into a siding forever. You'd be as interested in the scientific case as we were in 2020 and see a continuing need for what the company might one day be able to offer - but you'd have concerns about the mistakes made and the ability of the leadership team to seal the deal after 20 + years of slow progress, dramatic success and then last fence failure.

Existing shareholders - like Marley's ghost - carry the chains forged over the last 4 years and beyond. We're sticking with it because most of us were pulled in after Magic Monday and don't really know what we're doing in the markets. The cleverest science bods are rank amateurs in stock market terms, whilst the experienced traders who were not emotionally involved accepted the loss and got out as soon as the first bounce came in early 22. Most of us are stuck like MrC with averages in the £s - but unlike MrC who sees nothing but darkness, everyone else - even those of us still critical of the company - see the possibility of redemption. The company wasted the big chance the pandemic brought - but is finally on a track that we all can understand. I mkean we hope it is - as we have had zero information for 7 months . If the money lasts till the P2s are completed Synairgen will still be in the game. It'll surrender plenty of equity to pay for the big P3 to come and get through to authorisation but long suffering pis might still get something back.

Share something then Tom. Offer something to lift the level rather than moaning. What's the skinny on Reddit ? Everyone still chipper ? Better badinage I'm sure, but are you all still confident we'll be trialing within the next 2 months.

Posters on this bb haven't had anything substantive to discuss for more than 7 months & in truth it's become a little ragged. I'm sure our regular high quality service will resume when we get an update.

It's the same with everything American. Individual states make their own seperate laws based on all sorts of local circumstances or crazy prejudices and the Federal Govt treads a careful path through the middle. Only making Federal declarations in the most extreme circumstances to respect the semi independence of the Federal system. So when the FDA says don't drink raw milk, as it has done for decades, it's an advisory, unless it's important enough to make it a federal decree. 10m raw milk drinkers are told now that it may not be safe because of the threat of H5N1. How many of them listen is anyone's guess - but they'll most likely be the same freedom lovely hillybillies, chugging their milk straight from the teat as the anti-vaxing bumpkins who shuffled off in such prodigious numbers during the the pandemic. Everyone else will take heed and act according to commonsense and the scientific guidance and we'll all sit and watch the cornpokes heading for the exit door. The FDA will test and test again and destroy herds if necessary and stop the sale of raw milk countrywide if absolutely necessary and we'll hope that the early warning systems that Rick Bright acknowledges are working - are still doing their job. If they aren't and we find ourselves looking at a new pandemic with 50% fatality, they'll rush Mrna vaccines and monoclonals to the front line. The last thing anyone will be asking about or calling for, with cemeteries stacking them 6 deep - and at this stage of the drug's development - is SNG.

His subsequent tweet - posted 8 hours later - is more encouraging as he sees the preliminary FDA data released at last. Pasteurisation works - in milk and eggs. L:imited results so far but FDA promising more data soon from 297 samples from 38 states. Still just one human case.

https://twitter.com/RickABright/status/1784022075713151438

and this is the FDA update

https://www.fda.gov/food/alerts-advisories-safety-information/updates-highly-pathogenic-avian-influenza-hpai

Professional counselling MrC. World's gone mad.

Agree - it's nice to see any mentions and particularly in the specific area that is now so crucial- but the company should be well past all of this now. The P2s are starting within 10 weeks. That's the timescale they promised. The research is done - the assays are made - trialing sites approved and design ready. If this research has somehow made its way into trial design then great but they have to go soon or risk the whole venture. I'd prefer a partner now too - and I've outlined the reasons why before. Even the most optimstic poster would agree that with funds drying up - going broke before the P2s and then P3 (s) deliver is unthinkable

They should have dumped the quality director as soon as it was clear there was no fast route to market: Ie Feb 21st 2022.

'Naff off' - Norman Stanley Fletcher was the first to use that - Del boy the second and last. You're older than I thought Mani

It'll be disappointing if they do need to jv for the P2s. Far preferable to give away a slice of the pie after you've proven it's a good pie. On the other hand if your pie taster is himself a boulanger of some repute, loves what you do and is interested in helping you improve the recipe and putting it on all of his customers' shelves - it might be a match made in heaven.

Xv it's definitely new work. Funded by Synairgen and conducted by UKHSA at Porton Down

UKHSA. The Antiviral efficacy of IFN-B1a ( SNG001) against different SARS-CoV-2 variants, in vitro.

Amanda Horton, Sarah A Dudley, Matthew Wand, Daniel Packham, Irebe CanoCeja, Victoria J. Tear, Philip D,Monk J.Mark Sutton, Julia A.Tree ( 6 UKHSA 3 x Synairgen)

"In this study we tested the antiviral efficacy of SNG001, in vitro, against a variety of SARS-CoV-2 variants to provide reassurance that IFN-B1a was effective against the different variants as they emerged.

It's just perplexing though isn't it. Brysoa brings the news of the conference - and we start to feel a little happier. The next day pmjh posts Amanda Horton's tweet which shows the specifics of the poster presentation and we're even happier - hell Professional even apologises to the company. And the sp climbs dramatically, even if part of that rise was down to market-maker shenanigans. Then it's Thursday, the tweet is deleted - Synairgen makes a pitiful Linkedin post, seen by nobody, which instead of showing the data slide revealed the day before takes the reader to the Conference's homepage and then on to the preview paragraph we'd seen 2 days before and nothing substantive, and the ar.se falls out of the sp again. . I guess there are reasons for the nonsense - I guess we can still celebrate the fact that UKHSA has collaborated ( for as Brand says, they are in no sense a commercial lab ) on a new set of ivs - and we can still surmise on the interesting possibilities this may throw up. But the deleted UKHSA tweet makes no sense. It can't be a secret squirrel exercise. The board was up for all the world to see and snap for at least 2 days.Any tom dick or harry could have photographed it and posted it.

And we're left with Synairgen's hamfisted comms team managing yet again to turn a small but genuine nugget into pyrite. Our first tiny sniff of salvation after so long waiting and they've screwed it up.

And the company has done 2 sets of iv testing - the first in 21 and then Delta and Omicron in late 22