Member Info for Doc.Daneeka

Well read Fruits

This outbreak is over but it will remain a threat if Saudi hospitals drop their guard. If SNG finally reaches authorisation it may well play a roll in any future outbreaks. Recombinant IFNb has already tested successfully with Ritonavir in Saudi qith a large smaple of MERS cases, and as we know inhalation is a better and safer delivery method than injection.

https://www.nejm.org/doi/full/10.1056/NEJMoa2015294

And a review of the 2015 Korean outbreak led to this recommendation.

" Antiviral treatment

An antiviral treatment guideline has been published by the writing committee with support from the Korean Society of Infectious Diseases and the Korean Society for Chemotherapy [68]. The guideline recommended a triple combination regimen of type 1 interferon, ribavirin, and lopinavir/ritonavir for 10 to 14 days. However, the guideline was mostly based on expert opinions and further study for the optimal antiviral treatment in MERS is warranted. "

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840604/

I know what index case means Fruits - and this was clear in what I posted.

The teacher arrived in hospital and infected 2 patients: the first in A&E, the second in a shared room. Both patients were subsequently intubated in mid April.

MERS outbreaks historically spread within hospitals - with poor screening and diagnosis and a lack of ppe. This improved dramatically and serendipitously in Saudi and neighbouring countries during the pandemic as much stricter rules were introduced, and it's concerning that standards have slipped again. The WHO report recommends further re-education for hospital staff.

So we have one unexplained fatality and they're working to discover the original source of the infection. They've already tested dozens of family and contacts and found nothing and given the speed of infection to symptoms it really IS reasonable to suggest that 6 weeks after the teacher arrived at A&E - anyone he infected would be known by now.

The real index case for this outbreak is still unknown and remains a mystery, but MERS is a disease of dromedary camels and inevitably this WILL trace back in some way to a contact of some sort or infected milk.

"Most patients develop symptoms approximately 5 days after an exposure to an infected person or camel, but the incubation period can range from 2 to 14 days. In hospitalized MERS patients, the median time from the onset of symptoms to a person’s hospitalization is approximately 4 days. In critically ill patients, the median time from onset to ICU admission is approximately 5 days, and median time from onset to death is approximately 12 days.

https://www.cdc.gov/coronavirus/mers/clinical-features.html

Thanks Fruits. Always interested in the MERS situation. The report - whether deliberately or not - leaves out the clear evidence that cases 2 and 3 are contact infections of the index case ( He was in A&E with case 3 and shared a room with case 2 ) a 56 year old male school teacher - but it's still important to find his original point of infection. It will ultimately lead back to the dromedaries that carry MERS. They say he had no direct contact with the animals so he may be a secondary infection, which means there could have been others. He fell ill on 29th March and idea on 7th April, so it's reasonable to assume that if there was going to be a wider outbreak it would have happened by now. Still of concern but no epedemiological changes between cases and as WHO says - for now no need to change the threat level from Low. Newspapers like scary headlines and saying there are 3 non-camels linked cases makes it sound very scary indeed.

https://www.who.int/emergencies/disease-outbreak-news/item/2024-DON516

Good effort EFT. You've made an 18% return today.

Afternoon Dudio are you saying you've be confident of further investment at 5p but not at 5.86 ? Hardly a ringing endorsement. I'd encourage anyone who still believes to top up now - as news is long overdue and it must land in one form or another in the next month.

Thanks Elsol. Gloomy and realistic for where we are now - in this news vacuum. Things could still change dramatically for the better if Syn is about to tell us P2s are starting in H1:- and more importantly shows incredible data to back up its patient identification techniques. If we get a further non specific delay the game is up

Could you say that in English for the CSE Grade 2 Maths crowd please E

" This report should also include the "going concern" portion which Spacman has mentioned on a few occasions "

Thanks Wigster - can you or anyone else who might know about this express an opinion on the "going concern"

issue. Is Spacman correct that Synairgen may need to exclude the P2 trials in some way to pass this test ? We were told sufficicient funds until at least September but when they said this it was with trials starting in the winter, and I guess being over by now.

Fruits I notice you've moved from " they'll update us when they have something to say " to " unprecedented radio silence means something is going on "

My opinion, for a long time, has been that the longer they go without getting started on the P2s the more likely they will seek a JV at least to ensure the money doesn't run out mid trial

I've no idea how this all works but if DB took over Numis presumably they HAVE to issue a new broker's note at some point reasonably close to the acquisition. Is this how it works. And in that context is this not - 7 months on - routine and as unremarkable as the number quoted.

If this is entirely wrong please offer a correction.

BARDA promised Synairgen they would look for another suitable route forward when the ACTIV2 programme was shelved. (according to Synairgen anyway) Then STRIVE launched - which was about as suitable as anyone could have imagined, particularly given it's ambitions to trial drugs against a range of viruses - and SNG was overlooked. STRIVE now has 2 protease inhibitors ( last time I looked ) grinding through to a conclusion. If there was an easy fit for SNG in the states this was it.

Against this is the fact that we know one of the P2 trials will be in the US, which is supported by the the reported remark from Simon Shaw in relation to the P2 programme, saying that approvals were progressing better in the US than in the UK. And the fact that the company's website is still clearly aimed at the US.

My feeling remains that Synairgen is still on its own - in terms of major national and international support - possibly with support from J&J and/or AZ. I don't think a major platform trial is likely - either in relation to Fruits's 100 days or anything Barda might be launching. The one intriguing counter point to this, remains the Porton Down IV studies, which does seem to point to something significant - although in truth bevause of the company's silence on the matter it may still turn out that Synairgen initiated the tests

Haha thanks Mani. Quandoque bonus dormitat Homerus. I'll post it again tomorrow evening

RNS tomorrow anyone ?

Not many more weeks to pass before starting in H1 becomes an impossibility. They have a max of one month more before it becomes very difficult to meet the twice delayed deadline.

Fairly certain there'll be a big Clinical Programme update announcing they're about to start first, as they did with Sprinter when there was a similar amount of new information to divulge, and they will then need at least 2 weeks ( if prior trialing timescales are followed: SG016 2 weeks - Sprinter 3 and a half weeks ) before FPD.

I also think it's possible that they fire the gun on just one trial even though they said everything would start together, as they're under pressure to get something started, and they may be waiting for something significant that is not in their control to get one of them underway.

I can't see any possibility that they fob us off though. The sp would nosedive even further if there is not a significant and convincing update.

"Note that GSK acquired a 10 percent stake in CureVac for £130 million and provided a cash payment of £104 million to fund R&D. "

Hardly comparable. "Under the terms of the deal, GSK will make an equity investment in CureVac of £130m (€150m), representing close to a 10% stake, an upfront cash payment of £104m (€120m) and a one-time reimbursable payment of £26m (€30m) for manufacturing capacity reservation. "

Curevac's then Mcap of $1.3billion ( it rose to $5.4b ) versus Synairgen's current value of £13.5m plus cash & patents

The best we can hope is something like the very good deal that was made with AZ - but we won't get a deal before the P2s deliver and unless they're stellar it won't be a favorable deal.

Whether funds last this long is anyone's guess. Didn't the company say financials were good until at least September '24. Was this in the interim report or Q&A at the AGM ? Either way - when it was made it was with the expectation that the P2s would be done or almost done by September - and now of course that's impossible

You'll get another chance in a couple of months Doc. It'll then be a whole year with just one 4 minute Proactive interview from our CEO. An interview in which the interviewer seemed to think Synairgen had a new drug.

Posting again for new shareholders who won't know who he is

https://www.youtube.com/watch?v=Y3gJ9cP7fC8

You started the "charade " Fruits. Maybe stick to the end of the world

Sakura of course Fruits won't take your bet. He's an old bluffer who has been found out yet again.

There is another way to resolve this though, and that's to use one of the unimpeachable members of this bb to verify anything you want to present to rescue your good name. It'll have to include your work profile though, which is what you based most of your claims on. Nobody giives a sh.it about what you did at Uni, even if you were writing about Ifns ( no offence but seriously )

You said you have a long career in Interferonology and I'd like to suggest Doc83 or Wpa5 ( if they'd accept - or others if they decline ) to act as arbiters of your veracity and verify this.

If you are genuine you will accept this and they will offer assurances to protect your identity and I'm sure, not use anything you disclose maliciously.

It's all ridiculous frankly but you have been slandered and there's zero chance of any resolution unless you prove who you are.

You're an old and dangerous fool Fruits. Amazing really that you can describe " the uncontrolled H5N1 spread in the US " as an opportunity. But that's always been your default hasn't it... whether bird flu or monkey pox or the latest VOC ....hoping for an extinction level event to rescue your investment. Maybe you should invested in arms manufacturers instead

Haha of course you had - but decided not to share it with the groundlings

I think we all understood you perfectly Fruits. Nonstop junk you've posted today. The worst of it is the dangerously fake news about H5N1 in the States

"a real and escalating global threat of H5N1 human-2-human tranmission " One dairy farm worker in Texas tested positive for H5N1 sometime in March. This was reported on April 1st and he was said to have suffered an eye infection like conjunctivitis and was recovering. He's now well - and there have been no further cases. There has been no human to human transition.

What we have is a single human who probably caught the virus from the milking machine . Doesn't mean medicos in the States aren't concerned and some are saying there are likely to have been more, possibly symptomless, human infections and want more testing - and some are saying of course that the more species it infects the greater the chance of it mutating and/or making human to human transmission more of a possibility, but it's most certainly not as you hysterically and predictably describe it.

Here's the latest on - including warnings from scientists, which you can recycle back into your next claxon sounding post. Helping you to post more accurately. Your welcome.

https://www.npr.org/sections/health-shots/2024/05/02/1248538298/the-u-s-may-be-missing-human-cases-of-bird-flu-scientists-say

And here's somedirectly related homework for you.

"Public health risk of avian influenza A(H5N1) detected recently in dairy cattle "

https://who.zoom.us/webinar/register/WN_mlWO17leTpC56SulPtA6jw#/registration

Monday at noon - hosted by Maria Van Kerkove - WHO's lead on ... well you know what she leads on. Watch it and report back to the bb. Ta