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It's either poor writing - which is very likely - and they meant to say that UKHSA testing has confirmed previously shared iv results - or the UKHSA tweet yesterday was wrong, which can't be the case as we saw the data charts.

V odd that the tweet has been taken down though - as it was v straightforward and confirmed what was already released. Maybe they decided it was the wrong way or time to release the full data - for some reason. Or maybe someone at Synairgen got the wind up as the sp went a bit mad and put in a call.

All a bit crap frankly - but par for the course in terms of communication skills

8p is us topping up in light of some genuine and not insignificant news, which might mean a lot more than seems immediately apparent. 10p was trader driven - followed by the almost immediate and inevitable fallback when Prof and Td et al took their profits.

We haven't been played or taken advantage of - those who played it for the day did well - those that bought in again and held will see a return when the trials are announced.

There's gonna be a lot of this in the next couple of years if the company begins to deliver. Of course nobody trades in a news vacuum which is why the sp has been dormant for so long. As long as they meet the H1 deadline good times

are coming.

Mani I was poking fun at your inconsistency today. You are correct of course that Synairgen really should have made something of the presentation - either pre or post. Not an RNS but a tweet with the same data sheet or better still linked to a page on the website. Perhaps they'll get round to it tomorrow or Friday. Very odd behaviour - but we're well used to that by now. It's as if there's nobody doing comms at any level now.

Working late...... thanks a lot.

Nice to see you've found the perspective that seemed to be missing in your late morning post Mani.

11.37am

" I would have thought RM will now be forced to issue

a statement on the movement, you cannot ignore 50% in a day..

Either he explains the reason or declares there is not one..??

The NOMAD should insist on a response IMHO! "

Oh god here they all come. It's a leak - a jv - 2020 all over again - the lid's about to blow. Always good to see the rocket but seriously folks ignore all this shinola. The presentation is a genuine piece of good news but we are still waiting for the update and Synairgen for all its other failings - has always been drum tight.

Anyone telling you this is gonna blow wants to take your money before dumping

Timelines haven't changed. This is a response to yesterday's positive presentation and the fact that we know an update is very close. LTH's rushing to top up and kicking themselves for not doing so at 5p. And traders no doubt. 50% up at the moment and of course it could keep climbing, but if it can settle around 30% up after the bump and grind that'd be great.

Flagging up this significant addition from Brand.

" Porton Down is very much not a commercial lab. As much as this study was "funded by Synairgen" the UKHSA would have had to decide it was also in their interest/benefit to run the study, along with publishing and presenting the results "

Please pass on my apologies to pmjh Tommy. It was an unnecessary dig perhaps. Nice to know that i was correct though, that he's still invested, and presumably still confident, and that the Reddit forum I suggested to him and this board in the autumn of 2020 is still flourishing.

1. As part of the background prep for the P2s and Synairgen's desire for SNG001 to be seen as a multi viral agent - the company decides that a new and unimpeachable set of UKHSA IV assays is an affordable and neat way of tidying up the Covid data and showing multi efficacy. The work is affordable - at a time of dwindling resources - and clean. It will use this package in support of ongoing regualtory approvals for the new trials and in future development of the drug, specifically for Covid but also to support the broad spectrum argument. And the data created is now UKHSA data - with Synairgen playing no part in the analysis. ( Amanda Horton says " I’ll be presenting some of our #antiviral #SARSCoV2 data " OUR being the key word )

and/or

2. Something is brewing in terms of UKHSA's relationship with Synairgen. The IVs are funded by Synairgen but could have been suggested by someone else. Perhaps an important supporter or supporters at the heart of the UK medical establishment - who may susequentlybecome a sponsor.

Certainly more possibilities than these two - but I think these are the main options for us to consider.

It would clearly be more impressive and encouraging if the work had been instigated by UKHSA - but it's actually more encouraging for me to look at Option 1 - and to consider that this is the first tangible evidence of an unfolding strategy. It's minor, in the sense that anyone who needs to know will already know that SNG has survived the pandemic intact and not been deleted in the way that every Mab and some Vaccines have by the evolving virus - but it's also clever and timely.

Apart from the protease inhibitors that now provide the first line for defence for at-risk patients , but come with certain asterisks - there is still nothing that can genuinely call itself variant agnostic in te age of C19 except SNG001. And because we have the COPD data too - the case is already more than half made that SNG will work against every other respiratory virus.

The questions since the failure of Sprinter have been: Can they find the right patients, can they adminster the drug at the right time, how well will those vulnerable patients do with SNG versus soc, and ( selfishly) whether anything of the original company and our investment will remain at the end of the long process.

Well done again Brysoa - and whoever found it on Reddit. Twitter finds used to be pmjh'speciality. - sitting in his basement.

Not sure why you're on the attack again Fruits ? Here's a reminder of our exchange yesterday evening. You'll recall I'm sure - when I said it could hit 7 and UKHSA might tweet and you .. well ..you did what you do. Googled for 5 minutes and then got it wrong

DD "I doubt an RNS as well - but maybe they'll fire up the twitter laptop and go crazy. Might see 7p or beyond, tomorrow or Thursday if UKHSA gets active on its own socials. "

Fruits " UKHSA don't do rampy and they don't do commercial.

You might be lucky to catch a measles or scarlet fever update. "

Yawn - you say ?

Classy Fruits. If anyone actually knows it would be good - and possibly significant to know. If they were done this year - for instance - we could take it as a very positive signal. If it's from a year ago, maybe not so much.

Thinshins - this is the question I asked yesterday and there were one or two good replies and some junk from Fruits and Tommy who seemed affronted at the suggestion that it might be a bit odd to repeat exactly the same iv tests when already done by a very credible lab. Can't imagine it's normal practise.

Do we know when these in-vitro tests were done ?

Isabel Oliver has been CSO at UKHSA since May 2023.

I doubt an RNS as well - but maybe they'll fire up the twitter laptop and go crazy. Might see 7p or beyond, tomorrow or Thursday if UKHSA gets active on its own socials.

You can use SNG as a case study without mcommissioning new iv tests - so I'm inclined to believe Elsol's egg-on-face rationale. It's the only reason they wouldn't just go with Synairgen's own very good data. Cynically - If SNG does finally make it through they can say "we demonstrated SNG001 to be variant agnostic in our trials at UKHSA's Porton Down facility " Less cynically it might point to a new enlightened understanding of the simplicity and undeniable truth of SNG's non deleteable mechanism.

Will be interesting to see the presentation tomorrow and whether it goes beyond this and actually advocates for further trialling on SNG001 - it would seem a logical final paragraph

Time for your afternoon nap Fruits

Why then ?

Elsol I did read your comment with interest. And if would be amazing if a shareholder had really influenced this move in the way you suggest - and even more amazing if the medical establishment felt any pangs of remorse in overlooking SNG before now - or not showing sufficient support anyway - but my question was more about why they need new data. Is this perhaps to do with Porton Down working itself up in a new role and seeking to demonstrate competence in in vitro assay work with Covid 19. ? Obviously Porton Down is an important establishment and I think it may have done work on bird flu and mad cow disease but not sure if this might be a partial explanation

In other words you've no idea. You're such a pitiful nodding dog Fruits. Clapping - over celebrating - waving your little flag - offering nothing.

Hopefully someone else may have a useful response.

It's the first sniff of any kind of news since September - so very welcome. Seems rather bizarre though - as if UKHSA doesn't trust the results generated by the world class labs Synairgen used in '21 and '22.

Any reason why this would happen ? I can't think why - unless the assays differ substantially.

They could have presented the discussion of " the importance of continued monitoring of the efficacy of novel and licensed treatments for COVID-19 and preparedness for future pandemics." with the original data.