Cobus Loots, CEO of Pan African Resources, on delivering sector-leading returns for shareholders. Watch the video here.
The objective is to determine whether a low serum 25-hydroxyvitamin D (25(OH)D) level is associated with an increased incidence of deep venous thromboembolic events in patients with ischemic stroke. One hundred eighty persons admitted consecutively for inpatient rehabilitation at the Department of Rehabilitation of the First Affiliated Hospital of Wenzhou Medical University with a diagnosis of ischemic stroke from January 2015 to December 2015 were enrolled. The following demographic data were collected: age, sex, body mass index, and history of risk factors. The levels of 25(OH)D and the presence of deep vein thrombosis (DVT) by routine duplex imaging were also recorded. The value of 25(OH)D needed to predict DVT was analyzed using logistic regression analysis, after adjusting for the possible confounders. We found that 80% of patients admitted to the acute inpatient rehabilitation unit had low levels of vitamin D. Forty-seven patients had DVT, and the incidence of DVT was 26.1% within 3 weeks after the stroke event.
With all patients taken together, DVT occurrence as a dependent variable with the sufficient group as the reference used for vitamin D levels in the logistic analysis, deficiency of vitamin D was independently associated with the development of DVT (odds ratio = 4.683, 95% confidence interval: 1.396-15.703, P = .012).
In conclusion, low serum 25(OH)D levels were independent predictors of DVT in patients with ischemic stroke during inpatient rehabilitation stay in China. This finding reveals the critical role played by 25(OH)D in the pathogenesis of DVT.
https://vitamindwiki.com/Blood+clotting+%28Thrombosis%29+is+associated+with+low+Vitamin+D+%28yet+again%29#Reduced_clotting_after_300_000_IU_Vitamin_D_loading_dose_-_Oct_2019
Scientists at the University of Copenhagen have discovered that Vitamin D is crucial to activating our immune defenses and that without sufficient intake of the vitamin, the killer cells of the immune system -- T cells -- will not be able to react to and fight off serious infections in the body.
For T cells to detect and kill foreign pathogens such as clumps of bacteria or viruses, the cells must first be 'triggered' into action and 'transform' from inactive and harmless immune cells into killer cells that are primed to seek out and destroy all traces of a foreign pathogen.
The researchers found that the T cells rely on vitamin D in order to activate and they would remain dormant, 'naïve' to the possibility of threat if vitamin D is lacking in the blood.
https://www.sciencedaily.com/releases/2010/03/100307215534.htm
If we are trying to make T cells do the heavy lifting maybe patients should be checked for Vit D prior to starting treatment?
8th Para Bn. were the first British troops to enter Copenhagen having flown there from the UK landing just outside the city unopposed. Montgomery paraded British units a week later. Copenhagen was actually more or less cleared of Nazi forces and sympathisers by the Danish resistance during the hours just before the Para's arrived.
Konar, go to sky new live, scroll back the hours and minutes from the time now(12.20 to say 9.40) so about 2 hrs 40 mins .it's fairly short so you might need to do a bit of scrolling to and fro once you get to the Ian King segment
Hi Ruck. If I am honest, I personally think it would be a minor miracle if Scancell's solution was chosen as the main product and I wholeheartedly agree about the value of the extra coverage in the media and I say that not because I think the science is in any way inferior simply that the big guns have the resources to ensure they win the deal. I guess a better pitch would be to say that once the company's development overheads, manufacturing and loss of forward momentum on other projects is paid for we would be happy to do a deal on a similar basis as any other independently financed company pitching for the business. At least to cover the cost of our forthcoming Cancer trials... a clear financial runway courtesy of HMG through to moditope trials and beyond would be priceless.
Hi Ruck, any Vaccine (or anything else) is worth what people are prepared to pay for it. HMG are involved with a group of other countries and have already promised £200m or thereabouts towards developing a vaccine. They want to G20 to put in at least £100m each. They expect to pay a lot for the right product. If scancell pitch a £30m solution they are unlikely to be taken seriously. Big money buys security for people making the decision. I have been through this loop on a number of occasions... the old adage "no one ever got sacked for buying IBM " applies equally well to most Government contracting. I once proposed an IT training solution to the NHS for £10m all done and dusted, then they brought in "consultants" from one of the big accountancy firms and ended up paying over £300m for something that was hardly ever used, just because it came from a big US IT name. They could have built a new hospital with the money they wasted! Simple fact of life is you can easily reduce a price, it's not so easy putting one up.
Given that the expectation of the cost of producing a new vaccine is $500m and upwards, there is room to do a deal that is well within those expectations and yet provide Scancell with an excellent reward for their expertise and IP , Its not as if governments are going to reject the best fix for the problem for the sake of a few million dollars ( assuming Scancell are in the equation). My experience of government contracts is that the more they spend the more secure they feel in their decision.
No one in government is going to say "no" if Scancell say they want $4 -500 m to stop this disease. At that point Scancell may waive any further payments other than manufacturing costs and leave distribution to someone else if they are going to give it away.
Why they cost so much, Covid 19 specific and a very straight forward explanation of each step along the way by Dr. Jerome Kim, the Director General of the International Vaccine Institute (IVI). Also good description of why you need antibodies and T cells in the process.
https://youtu.be/5cYWd0N8nO4
My bad, long term then. but I guess it depends how old you are when you get the jab! even so, I think long term sounds to be a much better option than "please come in on Saturday morning for your booster jab" every 6-12 months. Imagine all the follow up that will be required if its an annual jab.
I think its a given that if there is a way of giving people a one-time vaccination against this horrid little virus, the Government would be keen to use it rather than have annual outbreaks because lots of people didn't turn up for a booster jab or thought the whole thing had gone away. it also puts Covid on the back burner as far as potential threats are concerned. Most developed economies would be thinking the same thing as another economic hiatus in the next decade or so would be virtually unthinkable. It looks to me that Lindy has once again thought something through a bit more than some of her contemporaries and maybe sussed a better way!
And therein lies the problem, the science is fantastic the commercial managemen is utterly lacklustre. I will keep bangingnthis drum..... the science is complex and the marketing and PR needs to present that science in ways that is easily understood. Most LTHs have got their heads around it, eventually but a new investor needs to know why he/she should invest here rather than following the herd and why he will need lots of patience! Lindy needed to do the "elevator pitch" on the radio stressing them long term benefit of the Scancell solution against further Corvid epidemics and the fewer, if no, side effects etc. The case for investors being that this solution will be prefered as a one time fix with repeat doses probably not needed. Its frustrating to so often get into a relatively good place and then somehow manage not to capitalise on it, its like scoring an early goal and then giving away a soft penalty just before half time, not game over but back to square one.
Interesting comment about being behind other potential vaccines from Lindy " I think we can catch up". This is not an easy thing to explain on the radio, I doubt many listeners will be any the wiser... antigens this, T Cells that, most people just want a jab and get back to work.
Scancell really do need to put some effort into simplifying the presentation of their technology if there is any value in having it understood by the vast majority including a lot of potential investors
There is some truth in the UV light inside the body idea, watch the video: AYTU is listed in the US and partnered with Cedars Sinae Medical Centre
https://aytubio.com/healight/
Oops , twitched and posted before completion! Just saying that we have waited ages for some news that has real impact on the SP and as soon as it arrives we start pulling it apart rather than just applauding the decision . I dont think we should try to overthink this, Lindy does not seem thr type to get sidetracked on a whim. To take resources away from her desire to conquor cancer, she must believe sha can make a real difference . If she does, and the board support her I am happy to fall in line Friday was the best day we have had for ages, a foretaste of what Scancell is capable of doing . Lets not spoil it for the sake of a few rounds of point scoring off each other.
Anyone got any thoughts about if graphene would help this process?
https://3dprintingindustry.com/news/u-s-army-develops-high-strength-multi-polymer-filament-for-use-with-low-cost-3d-printers-171038/
I hear the cheaper argument but it smacks of someone in the purchasing department being penny wise and pound foolish. For example, how many extra sets of instruments did they have to buy to cover the time it takes to ship sets back and forth? How often can they go to India to check the quality of work there and what is the fallback position if they dont measure up?
On the subject of washing, I think some hospitals still have their own laundries, but I imagine many farm out their washables.
We need to become far more self sufficient in the UK , being in the EU for 50 years has done us no real favours wih 1000s of acres of land "set aside" and many key functions being run by foreign companies including Greater Manchester trams and traffic lights. Its time for the UK to start the process of reclaiming our own destiny in what seems to be an increasingly uncertain world. I dont want to be in a low skill low wage economy, I want to live in a smart, highly skilled highly efficient country where penny pinching is a thing of the distant past.
I have been advocating for a while that a £130Bn a yesr organisation shouldnt be dependent on buying critical equipment from overseas suppliers. There is plenty of money within the NHS to have its own factory making PPE , adding Graphene into such an operation would enable it to be come a world leader and as such a profit centre. There are plenty of empty factories in the North and there is a workforce ready to get started. New skills, new jobs, security of supply , what's not to like?
From the Guardian Sept 2019
"NHS hospital trusts are being crippled by the private finance initiative and will have to make another £55bn in payments by the time the last contract ends in 2050, a report reveals.
An initial £13bn of private sector-funded investment in new hospitals will end up costing the NHS in England a staggering £80bn by the time all contracts come to an end, the IPPR thinktank has found.
Some trusts are having to spend as much as one-sixth of their entire budget on repaying debts due as a result of the PFI scheme. PFI was introduced by John Major’s Conservative government but its use proliferated in the Blair era."
The NHS also has £83.4 Bn in reserves in case of being sued for negligence according to last years accounts, enough to buy its own factories making whatever PPE it needs and pay off its PFI debts. (In 18 /19 , negligence claims amounted to just over £2 Bn and yet they added £6.2Bn to the pot).