Member Info for Dalester

Apols if my original post sounded pessimistic, it wasn't intended to. It mainly struck me that whilst there have been quietish spells, they could have spent some time looking at some of the alternatives for their technology.
Rats, I recalled the stuff about Melanoma in horses from back in 2012 and that it seemed a reasonable route for a licencing deal of some sort. If we had let one of the big players in the Animal Health market have a couple of years to play with immunobody at the time we may have had a regular income stream from that source by now. All "ifs and "buts" I know but if it had worked for Horses who knows where it might have lead to and maybe at a faster pace? I'm guessing its easier to get permissions to test on animals than humans? The Dog vaccine Ivy mentioned (ONCEPT?) is 4 or 5 doses at $1000-$1500 per dose! A 10% royalty on 20,000 doses would bring in $2m- $3m a year to Scancell!
Sometimes, its the ability to slice and dice your IP that pays off in the long run, I bet JK Rowling never envisioned films and merchandise when she started writing Harry Potter!

I wonder if anyone has given this conversation any thought since 2012? This could be plan B!
Copied from another place but I remember there being quite a lot of discussion at the time:
Hey Soulac Don't know whether you've noticed yet but you have just been answered on LSE. You asked: Dose this vaccines have any value in the animal world? Pale Rider replied with a series of posts: Soulac - Jabs For Pets Today 10:23 Yes is the answer to that, big time! The market for treatment of cancer in pets is huge. Scancell's immunobody platform for the production of vaccines to treat cancer and infectious diseases can be licensed to other companies for the production of their own vaccines. Scancell has a number of partners already developing vaccines using the company's immunobody technology. It is expected that pharmaceutical firms that currently specialise in the provision of cancer treatments for animals, principally pets, will be interested in pursuing Scancell's DNA vaccine approach simply because of its outstanding results in animal studies. http://www.vetmed.wisc.edu/Animal_Cancer_Treatment.9.3.html Jabs For Pets - Melanoma Today 11:03 Dogs can develop melanoma of the mouth and this is one condition for which DNA vaccines are already being approved. Of course it must be emphasized that pets can develop all the cancers that humans develop ..... lung, breast and so on. That is why this market is expected to be so important now. It is estimated to be worth tens of billions of dollars. http://www.examiner.com/article/dogs-oncept-vical-s-new-therapeutic-dna-vaccine-for-treating-canine-oral-melanoma-approved-by-usda Marketing Drive Today 11:28 Aside from Scancell's cancer vaccines, there is their globally patented technology on which these vaccines are based, the company's ImmunoBody® platform. This DNA vaccine technology can be used to manufacture vaccines to treat infectious diseases as well as cancer. In fact it is the company's intention, upon completion of SCIB1's Phase 1 trials, in December this year, to offer the platform to other vaccine companies using data from Phase 1 as a marketing aid [its important to bare in mind that Phase 1 will, in addition to its initial objective to test for toxicity, gather clinical data "to demonstrate cellular immune response and tumour response"]. Combined with the data for SCIB1's success in animals and the equal success of SCIB2 in animal studies it is hoped that the platform will be eagerly exploited by developers of vaccines for humans and also by those developing vaccines for companion animals.

FBI Director Chris Wray on the extent of Chinese spying and theft on the USA: Might go some way to explain the VRS situation.

https://www.fbi.gov/news/speeches/the-threat-posed-by-the-chinese-government-and-the-chinese-communist-party-to-the-economic-and-national-security-of-the-united-states

If I am right , I guess so. It's pretty much guesswork other than the numbers seem to add up. It could be just a coincidence. I have no idea what to read into it if anything at all.

Diggle added 2,925,000 shares on December 17th , then disposed of 1,500,000 on April 28th . Yesterday there were 700,000 of round figure (100,000 +) sales and today 725,000. I reckon he has sold all the extra shares he bought on 17th December .

To be honest, I wouldn't trust the FDA any further than I can throw a grand piano, there seem to be too many huge corporations that are much too cozy with FDA people. I think a much better strategy is to get proof of concept in the UK or similar jurisdiction and then start to accumulate others around the globe, leaving the FDA to whichever large Corporation decides its wants our products to sort out.
https://www.fdareview.org/2019/07/29/worried-about-big-pharma-then-reduce-the-fdas-regulatory-power/
http://www.center4research.org/fda-rushing-risky-drugs-market/
We seem to forget that the USA is a foreign country with its own ambitions and ways of doing things, it is foolhardy to assume the FDA would act impartially towards a UK based operation, especially if US companies have eyes on it or its technology.

I did, but I haven't.

Indeed it does lead to something, nearly half a million people who now know a little more about vaccines than they perhaps did before they took a few minutes to watch it. Half a million people who will speak to others and point out that putting all your eggs into one basket is not a prudent policy. This is a nail that needs hitting on the head again this week. if the message is delivered often enough eventually Government will take notice, perhaps someone will mention the "Nottingham Vaccine" during the interminable 5 o'clock presentations this week?

This whole covid19 epidemic has been handled disastrously by Government , civil serpents and much of the NHS. 100s of Billions have been spent to very little effect. The Elderly in care homes have been deliberately exposed and 10s of thousands of Cancer sufferers been put at greater risk and it now all seems to me be more of a backside covering exercise. If Covidity never sees the light of day because Government wouldn't put a few millions into it and the main Oxford-based contenders dont deliver, Handcork and Johnson could be totally culpable for 1000s more unnecessary deaths should Covid 19 or a variant ever return. Good job they are politicians, they would be unemployable elsewhere.

It would do no harm to ensure every MP gets a copy of the video ASAP you can find your MPs email address here
https://www.writetothem.com

Its £2.06m at todays prices which is £412k per year . A bit more than £250k then, and better than a poke in the eye with a pointed stick?

It seems that Hydroxychloroquine might still be a game changer if used early.
https://academic.oup.com/aje/advance-article/doi/10.1093/aje/kwaa093/5847586

Interesting discussions today if disappointing SP . The thing that grinds my gears about the finance situation is that the Government is happy to shell out £2.5Bn on filling potholes over the next 5 years but if we dont find a vaccine that works how many will be using the roads anyway? Would it really hurt anything to chuck £20+m at Scancell even if in hope rather than expectation at this stage? The faster we fix this, the faster we start paying off the debts we are running up. Finger are crossed that someone will take a punt on an alternative solution not from Oxford.

More to do with their inability to create any excitement around their science. They keep selling the sausage instead of the sizzle. So, they RNS that they are building a vaccine .. hurrah, then they do a few interviews that viewers, presenters, listeners dont have a clue about.... Result is wasted effort. They should have simply said, "we have what we believe is an exceptional treatment for loads of cancers and have now applied that approach to Covid. We think our proposed solution will be better than antibodies especially for older people and will be longer lasting and will stop other future Corvid viruses too". Noone cares about the "how" they just want to know what it does , how well it does it and how soon they can get it. So the effort to get some PR coverage has been wasted on an audience that couldnt understand most of it and the SP starts it inevitable slide back to 4 or 5p .
This share needs regular news and updates. The initial Covid announcement needed another one soon afterwards just to stir the pot . Above all else they need to do a deal with someone for something, anything. Is any thing happening with BioNtech?Avidimab? Is there any sign of Cancer Research starting their trial? Who knows? Certainly not shareholders.

The objective is to determine whether a low serum 25-hydroxyvitamin D (25(OH)D) level is associated with an increased incidence of deep venous thromboembolic events in patients with ischemic stroke. One hundred eighty persons admitted consecutively for inpatient rehabilitation at the Department of Rehabilitation of the First Affiliated Hospital of Wenzhou Medical University with a diagnosis of ischemic stroke from January 2015 to December 2015 were enrolled. The following demographic data were collected: age, sex, body mass index, and history of risk factors. The levels of 25(OH)D and the presence of deep vein thrombosis (DVT) by routine duplex imaging were also recorded. The value of 25(OH)D needed to predict DVT was analyzed using logistic regression analysis, after adjusting for the possible confounders. We found that 80% of patients admitted to the acute inpatient rehabilitation unit had low levels of vitamin D. Forty-seven patients had DVT, and the incidence of DVT was 26.1% within 3 weeks after the stroke event.
With all patients taken together, DVT occurrence as a dependent variable with the sufficient group as the reference used for vitamin D levels in the logistic analysis, deficiency of vitamin D was independently associated with the development of DVT (odds ratio = 4.683, 95% confidence interval: 1.396-15.703, P = .012).
In conclusion, low serum 25(OH)D levels were independent predictors of DVT in patients with ischemic stroke during inpatient rehabilitation stay in China. This finding reveals the critical role played by 25(OH)D in the pathogenesis of DVT.
https://vitamindwiki.com/Blood+clotting+%28Thrombosis%29+is+associated+with+low+Vitamin+D+%28yet+again%29#Reduced_clotting_after_300_000_IU_Vitamin_D_loading_dose_-_Oct_2019

Scientists at the University of Copenhagen have discovered that Vitamin D is crucial to activating our immune defenses and that without sufficient intake of the vitamin, the killer cells of the immune system -- T cells -- will not be able to react to and fight off serious infections in the body.

For T cells to detect and kill foreign pathogens such as clumps of bacteria or viruses, the cells must first be 'triggered' into action and 'transform' from inactive and harmless immune cells into killer cells that are primed to seek out and destroy all traces of a foreign pathogen.

The researchers found that the T cells rely on vitamin D in order to activate and they would remain dormant, 'naïve' to the possibility of threat if vitamin D is lacking in the blood.
https://www.sciencedaily.com/releases/2010/03/100307215534.htm

If we are trying to make T cells do the heavy lifting maybe patients should be checked for Vit D prior to starting treatment?

8th Para Bn. were the first British troops to enter Copenhagen having flown there from the UK landing just outside the city unopposed. Montgomery paraded British units a week later. Copenhagen was actually more or less cleared of Nazi forces and sympathisers by the Danish resistance during the hours just before the Para's arrived.

We have been infested with several single figure trades per day for the last 3 or 4 weeks has anyone got any ideas why?

Konar, go to sky new live, scroll back the hours and minutes from the time now(12.20 to say 9.40) so about 2 hrs 40 mins .it's fairly short so you might need to do a bit of scrolling to and fro once you get to the Ian King segment

Hi Ruck. If I am honest, I personally think it would be a minor miracle if Scancell's solution was chosen as the main product and I wholeheartedly agree about the value of the extra coverage in the media and I say that not because I think the science is in any way inferior simply that the big guns have the resources to ensure they win the deal. I guess a better pitch would be to say that once the company's development overheads, manufacturing and loss of forward momentum on other projects is paid for we would be happy to do a deal on a similar basis as any other independently financed company pitching for the business. At least to cover the cost of our forthcoming Cancer trials... a clear financial runway courtesy of HMG through to moditope trials and beyond would be priceless.