RE: Sanofi have just freed up billions ££ for acquisitions?17 Jun 2020 13:17
Foralumab
Foralumab is a fully-human monoclonal anti-CD3 antibody, in-licensed from Novimmune SA in December 2014. It is being developed for treatment of inflammatory and autoimmune diseases.
Point mutations in the constant portion (Fc) of the antibody to minimize adverse immune responses (Cytokine Release Syndrome or CRS) produced by other anti-CD3 antibody therapeutics.
Foralumab binds to the T cell receptor complex (TCR) modulating levels of regulatory and effector T cells and the inflammatory response.
We believe that oral and intranasal administration of Foralumab has the potential to reduce inflammation while minimizing the toxicity and related side effects associated with intravenous administration.
Foralumab can be a potential therapy for nonalcoholic steatohepatitis, or NASH, and Crohn’s disease as well as neurodegenerative diseases such as multiple sclerosis, or MS.