RE: Rampy Ramping25 May 2020 13:10
AT least we can back up our arguments or points of view with facts. Meanwhile Zeb just sings mud.
TILS is with the 2 big company Covid-19 treatments, and TILS has already shown 2 distinct advantages over Roche's Actemra and Regeneron’s Kevzara. Hence why TILS has had to file the patent for this treatment very quickly. They have a major competitive advantage going forward - and none of this has been reflected in the previously over sold prices.
The recent news is that Ventilators are causing permanent lung damage, because they are forcing oxygen in, which is not being totally used by the lungs due to the lung infection. Therefore the infection has to be cleared or the patience dies. TILS targeting drug and procedure (superior) and targets the lungs to clear the infection that is actually causing death. :) / this is home run, considering to major drugs have worked in China and these are intravenous delivery only and do not deliver directly to the lungs. They also caused poor immune responses because they’re humanised and not like TILS drug which is human ready and will not have any impact on human immune system.
TZLS-501 by Tiziana Life Sciences
Tiziana Life Sciences is developing its monoclonal antibody named TZLS-501 for the treatment of COVID-19. TZLS-501 is a human anti-interleukin-6 receptor (IL-6R), which helps in preventing lung damage and elevated levels of IL-6.
The drug works by binding to IL-6R and depleting the amount of IL-6 circulating in the body thereby reducing chronic lung inflammation.
Actemra by Roche to treat coronavirus-related complications
China approved the use of Roche’s Actemra for the treatment of severe complications related to coronavirus. Drugs like Actemra have the ability to prevent cytokine storms or overreaction of the immune system, which is considered as the main reason behind organ failure leading to death in some coronavirus patients.
Actemra is also being evaluated in a clinical trial in China, which is expected to enrol 188 coronavirus patients. The clinical trial is expected to be conducted until May 10.
Regeneron’s REGN3048-3051 and Kevzara
Discovered by Regeneron, the combination of neutralising monoclonal antibodies REGN3048 and REGN3051 is being studied against coronavirus infection in a first-in-human clinical trial sponsored by the National Institute of Allergy and Infectious Diseases (NIAID). The safety and tolerability of the drug will be studied in 48 patients.
Both the antibodies bind to S-protein of MERS coronavirus. The intravenous administration of the drug in the mouse model of MERS resulted in the high-level neutralisation of the MERS coronavirus in circulating blood with reduced viral loads in the lungs.
Regeneron has partnered with Sanofi to evaluated Kevzara, a fully-human monoclonal antibody, in a phase two/three clinical trial in patients with severe COVID-19 infection. Kevzara is approved for the treatment of rheumatoid arthritis and is known t