RE: Change of focus15 Nov 2021 19:40
Poidster - The following IMO is the non-covid future I think NCYT has in mind:
This from the Full Year 2020 Results and update on strategy:
"o Post-COVID-19 testing - Addressing unmet testing needs beyond COVID-19 building on its established central laboratory customer base with a high value test menu, such as pathogens resistant to antimicrobials , sepsis, transplantation (CMV, EBV, BKV), as well as building a test menu for its near-patient testing"
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Source: https://www.cedars-sinai.org/health-library/diseases-and-conditions/c/cmv-and-transplant-patients.html
"What causes CMV in transplant patients?
CMV infection is spread from one person to another. The virus is passed on when a person comes into direct contact with an infected person’s bodily fluids. These include blood, urine, saliva, semen, tears, and breastmilk. Many people are first infected with CMV during childhood. A pregnant mother can also pass CMV to her unborn child.
People who have organ transplants are more likely to get an active CMV infection. Transplants include a solid organ, bone marrow, or stem cell transplant.
The medicines you take after an organ, bone marrow, or stem cell transplant can help prevent damage to your donated organ. But they can have other effects on your immune system. They make it harder to fight off CMV and other infections. In the case of CMV infection, most transplant patients who develop problems from it have activated the CMV that has been dormant in their body for many years.
Which transplant patients are at risk for CMV disease?
Certain types of transplants may have a higher risk for CMV. These include a lung or a small bowel transplant. "
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Souce: https://www.nature.com/articles/s41409-019-0548-7
Souce: https://www.nature.com/articles/s41409-019-0548-7
EBV:
"Epstein-Barr virus (EBV) is a ubiquitous herpes virus that infects the majority of the population worldwide. The virus can establish a lifelong latent infection in host B-lymphocytes. In the setting of immunocompromise as is the case post transplantation, the virus can reactivate and cause one of the deadliest complications post hematopoietic stem cell transplantation (HSCT), post-lymphoproliferative disease (PTLD), the incidence of which has been increasing. Multiple risk factors have been associated with the onset of PTLD such as age, reduced intensity conditioning, EBV serology mismatch and cytomegalovirus (CMV) reactivation. The rarity of clinical trials involving PTLD and the lack of approved treatment modalities renders the management of PTLD challenging."
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Source: https://www.kidney.org/atoz/content/bk-virus-what-transplant-patients-need-know
What is BK virus?
"BK virus - a virus that most people get in childhood. Symptoms can feel like a common cold. Once you get a BK virus infection, it stays in your system for good. Sometimes, when your immune system is not working well, the virus wakes up. Then it can cause symptoms of infection.
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