Roundtable Discussion; The Future of Mineral Sands. Watch the video here.
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Had a busy day working so this is the first chance I have had to look at how my investment in SAR is doing. Only 14% down today so not bad relatively. I can't wait for tomorrow!
I definitely don't like the corrupt pattern here, yet another ridiculous drop based on absolutely nothing
One day maybe Rayboy - one day
Don't like patterns laz only straight lines up 👍😂
This pattern will carry on until news drops of some description. In the mean time there is clearly an after hours sell primed to justify the sp
How the hell we are these levels is beyond me. The funding was an error of huge magnitude but again we see the AIM in action. The pants have been shorted off this. How many times have I said that there is no place for shorting outside the FTSE250. UK Govt weak with the City period.
I know I’m torturing myself but I can stop myself checking for news! Something must be very imminent now. I’m expecting a double whammy of an update on 1a testing and the announcement of a new funding plan which combined will see a dramatic rebound in the share price. I’m watching this space!!
....Also news this week, good or bad it will hopefully draw a line under this poor run. We have a 4 day trading week this week and a 4 day trading week next week and the introduction of the new ISA allowances from 6th April.
Data to come from 1801 and maybe an update from 737. Not out of the choppy waters at the minute but weather forecast is for calmer seas!
Imagine a world where dozens of research papers have and are regularly published on any given disease topic going back years Imagine the same world where they are not always translated and because of the historical volumes, no one can read, digest and remember their detailed content. Imagine someone whose brain would allow reading at say 10,000 words per minute with total recall plus an ability to extract critical and related research data. The possibilities are endless. Welcome to AI.
OR... look at that gap-up when there's news! : )
Only another 14 pence to go and then we can't drop any further!
Why would we be delisted. As laughable as the MC is it’s still about£10 million . You can be on aim in the hundreds of thousands. Not a cheery thought I agree. As always we are waiting on results
Roivant ends longshot lupus program after phase 2 fail
Roivant’s CEO Matt Gline always knew the lupus drug brepocitinib was a longshot: “Anybody who is not afraid of a lupus study is an idiot, you shouldn’t trust them,”
The assumption is always' they'll benefit if we benefit... but we sometimes benefit without them'.
just have to hope that, whatever the funding is and when it arrives, it's not so crushingly low that there's a good chance it bounces back to 50 before results.
We only need to 10 bag to get back to £1.50, 🫤
What a fooking shambles. I don’t think the BOD have any interest in the PI’s. They are probably busy working out if they can ring fence the IP and prevent it being sold off to settle any creditors claims. Is a Pre-pack administration a possibility if they are delisted? Tim and John won’t want their work to just disappear, plus 737 has potential value. The longer the silence the more I suspect we will get shafted.
Been here for 12 years, although I did delete my account a few years back and then just remade one recently as I felt I wanted to comment due to all the negativity.
I regretted when I was selling at 390 for not buying at 10, my average was about 70 (all post will use new money prices). So I have since done a few top ups over the past week (do expect it to fall further on funding news but I have done 12 years here I can (hopefully) do another 12).
All I remember from the 390 time is everyone thinking we are never going down again, now all I see is we are going bust.
I was selling then and I am buying now. If we go to 0 then we go to 0 but really the negative comments here just make me feel its time for buying.
I must admit I didn't think 28 was going to break downwards.
Although probably already posted by Citizen - keep up the good work.
Abstract
Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family of intracellular signalling molecules. By participating in signalling pathways downstream of type I interferons, IL-12, IL-23 and IL-10, TYK2 elicits a distinct set of immune events to JAK1, JAK2 and JAK3. TYK2 polymorphisms have been associated with susceptibility to various rheumatic diseases including systemic lupus erythematosus and dermatomyositis. In vitro and animal studies substantiate these findings, highlighting a role for TYK2 in diseases currently managed by antagonists of cytokines that signal through TYK2. Various inhibitors of TYK2 have now been studied in human disease, and one of these inhibitors, deucravacitinib, has now been approved for the treatment of psoriasis. Phase II trials of deucravacitinib have also reported positive results in the treatment of psoriatic arthritis and systemic lupus erythematosus, with a preliminary safety profile that seems to differ from that of the JAK1, JAK2 and JAK3 inhibitors. Two other inhibitors of TYK2, brepocitinib and ropsacitinib, are also in earlier stages of clinical trials. Overall, TYK2 inhibitors hold promise for the treatment of a distinct spectrum of autoimmune diseases and could potentially have a safety profile that differs from other JAK inhibitors.
Conclusions
The emergence of targeted anti-cytokine therapies has been a major breakthrough in the treatment of autoimmune and inflammatory diseases. Discoveries relating to cytokine signalling through addressable kinase targets led to the development of JAK inhibitors that showed evidence of efficacy, tolerability and safety across multiple indications. Although TYK2 is a member of the JAK family of receptor kinases, its actions are limited to a specific set of cytokines, predominantly signalling downstream of IL-12 and IL-23 and the type I interferons, and to some extent IL-10 and other cytokines, without affecting signalling downstream of classical type I cytokines or gp130 ligands such as IL-6. Recognition of the actions of TYK2, and the known efficacy of IL-12–23 blockade in psoriasis and PsA, as well as of type I interferon blockade in SLE, has spurred the development of TYK2 inhibitors in these indications. The TYK2 inhibitor deucravacitinib is now approved for the treatment of psoriasis on the basis of positive phase III trials, whereas preliminary evidence of the efficacy of deucravacitinib in phase II trials in PsA and SLE requires confirmation in the ongoing phase III trials. A potentially unique safety profile of TYK2 inhibition compared with other JAK inhibitors, on the basis of the finite list of cytokines in whose signalling it participates, was forecast and so far, upheld in clinical studies, at least with respect to laboratory evaluations. Whether the safety profile will be different from currently approved JAK inhibitors and biologic DMARDs with respect to the rarer events of MACEs, malignancy and VTE will have to await the results of much larger, longer-term studies and analyses. Two other inhibitors of TYK2, brepocitinib and ropsacitinib, are at an early stage of development and have both shown preliminary evidence of efficacy. However, consistent with their binding to the ATP binding site of JAK and also inhibiting JAK1 and/or JAK2, initial data suggest that these drugs might be more similar to the approved inhibitors of JAK1, JAK2 and/or JAK3 than deucravacitinib in terms of safety. The potential application of TYK2 inhibitors in other indications, such as in cutaneous lupus as suggested by positive findings for skin disease in the phase II SLE trial38 and dermatomyositis as suggested by evidence from genetic studies and the type I interferon signature associated with dermatomyositis75, awaits further clinical trials in these conditions, as does potential application of TYK2 inhibition for the treatment of inherited interferonopathies.
Data.
I think consolidation was the turning point here. In my experience it’s always been a complete disaster and here is no different. I’m at the point now were I just have to hold as there no point in selling out now after 14 long years! Just hope it can be turned around but I’m not holding my breath!
With respect, I would suggest that the biggest threat to Morale is the plummeting SP and the utter silence from the board.
The share price is almost down to ‘pre-consolidation’ high levels (a 50 to 1 consolidation).
Even if Robinhood wasn’t posting - morale would still be in the toilet.
The Brokers/MMs have controlled and destroyed this sp. Collusion here and at Genedrive. Anyway, all of the Fudsters are out in force ffs! Must be getting close to the new ISA allowances.
How can anyone add to see it fall? - This is potentially a big opportunity for all shareholders. For those unfortunate to buy very high I suspect there is only a limited number of shares that they could purchase at that time. They could probably get the same number of shares for peanuts here. Going bust would be the only way to lose money - your call.
I’d say it was the SP constantly being dragged down even when buys outstripped sells .The BOD have destroyed this company and it’s always the same when people say they must be in a closed period only to find out they haven’t and done jack sh@t over that period