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"In humans, recent clinical studies evidence a positive correlation between elevated plasma levels of TMAO and an increased risk for major adverse cardiovascular events. A direct correlation between increased TMAO levels and neurological disorders has been also hypothesized"
BTW Gixer I emailed Atanltia with that link in Nov and they replied --
Thank you for forwarding on this video, it is very interesting. I am the project manager working on this study and am more involved with day to day running of study ensuring team are following SOP etc but I work closely with scientists who designed the study and will be analysing the results so will pass on this information to them.
The study we are running is investigating if consuming the equivalent of 3 tomatoes a day for four weeks will significantly reduce levels of TMAO in the urine and blood. I would have thought TMAO is more linked to cardiovascular disease, however we are collecting kidney markers in the blood as part of a safety blood profile so will be interesting to see if TMAO is reduced from tomato consumption and in turn could have a positive effect on these kidney markers.
I emailed Ivor and he replied that ( my words ) big Pharma will use such markers as TMAO as a selling point knowing full well that they mean nothing to overall health , but we all knew already that big pharma are from Hell. I didn't know Ivors qualifications , whats on a piece of paper doesn't matter as much as the person IMO. He is in charge of reducing the Irish heart disease problem so he must be a decent sort.
Well thats one view on TMAO I suppose but I don't think I would trust my health on a chemical engineer that was shortlisted for “Irish Chartered Engineer of the Year”
Does he have any medical qualifications? I don't so wouldn't like to comment further.
That's real news Gixer, thanks yet again.
The latest studies regarding BP reduction surely has to have been funded with a new productin mind.
Anyone who says this has all been done too slowly has a point, but did a single one of us know the timescale involved in developing a product with health benefits that keep on evolving. The fake medical student throws in the line that he saw the data way back then. The data then in comparison to the data now? And the further data that could follow as and when the brilliant scientists are funded to continue their work?
TMAO is a protein that shows you have being ill , what is the point of trying to change the ' you have being ill ' signal, it will do nothing .
Out of stock at the moment but were we aware Fruitflow Plus was available here?
http://www.lloydspharmacy.com/en/fruitflow-omega-3-30-capsules
Not knowing the time scales involved in Blue Cap approval is frustrating as is not knowing what health claims have/are being applied for.
With any luck lowering Blood pressure is high on the list.
Great work Gixer. I am pretty certain bi-health are really pushing hard now with all the different trials. Hopefully blue cap by September/October just right for releasing there new products. As hopefully coved-19 will be under control and lock down measures stopped. I think people will become very health conscious after this virus. This information is maybe why we had the sudden increase even though I am 100% certain no leaks from PXS. They are squeaky clean and very honest company.
No idea what a pilot study like that would cost wellsite.
Thx Gixer
I guess that’s probably 250£k DSM have spent on this
W$
COMPOSITION FACILITATING LOWERING OF BLOOD PRESSURE AND DIETARY SUPPLEMENT
Publication Number
WO/2020/077747
Publication Date
23.04.2020
Applicants
BY-HEALTH CO., LTD.
"the water soluble tomato concentrate, folic acid, Vitamin B6, Vitamin B12 and Vitamin B2, and the combination of a plant extract composition and a vitamin composition achieves a synergy that enhances the effect of lowering blood pressure."
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020077747&_cid=P10-K9F8JJ-45635-1
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020077747&tab=FULLTEXT&_cid=P10-K9F8JJ-45635-1
Luke, over 100 regional consumer healthcare brands/products with fruitflow have been launched. However we dont know how many of those products didn't make it.
You will find the companies cash position in the interim results RNS.
Completed early despite what is happening in the world.
Study Completion:
June 2020 [Anticipated]
March 13, 2020 [Actual]
A Pilot Study to Investigate the Effect of Water-soluble Tomato Extract on TMAO
Locations
Ireland
Atlantia Food Clinical Trials
Cork, Ireland
Sponsors and Collaborators
DSM Nutritional Products, Inc.
https://clinicaltrials.gov/ct2/show/NCT04160481
how much cash do these guys have these days? is a commercial product there?
Zeus, the Chinese are allegedly obsessed with male prowess. That's why they use such exotic potions and powders. If there was as much as a hint of Fruitflows "off label" benefits, then the product would be in huge demand and we could then expect a huge rise.
There are 2 different agreements (not SPLITS) with By-Health.
1/ "The Company (PXS) has previously announced it was working with DSM and BY-HEALTH Co., Ltd (‘By-Health’), a
listed Chinese dietary supplement business valued at approximately £3bn, to support the planned launch of a
number of Fruitflow based products in the Chinese market."
Hopeful outcome, By-Health get Blue Cap and release products into the Chinese market after purchasing Fruitflow and/or Fruitflow products from DSM. Profit share between DSM and PXS.
2/ "In August 2019 the Company (PXS) was delighted to announce it had signed an open-ended collaboration agreement
with By-Health, in support of By-Health’s planned launch of Fruitflow based products in the Chinese market.
Project work will be managed and conducted by Provexis primarily in the UK, with the first project agreed
concentrating on the use of Fruitflow with nitrates in exercise, an area of considerable commercial interest to
By-Health. The agreement further strengthens the close relationship between By-Health and Provexis."
Hopeful outcome, By-Health pay PXS for project work carried out by Provexis. By-Health get Blue Cap and release products into the Chinese market after purchasing Fruitflow and/or Fruitflow products from DSM. Profit share between DSM and PXS.
That,s how I see it anyway and no mention of a 3 way split.
https://provexis.org/wp-content/uploads/2019/12/PXS_2019-11_Provexis_plc_30-Sep-19_interims_31-Dec-19.pdf
Zeus, there is demand for Fruitflow, but at present, currently not to the extent that is needed to roll in the cash. It's an excellent product with more possible beneficial effects than can be currently supported by published science. This product has been hampered by poor (IMO only) Provexis management dating back many years and, I have to assume, a pretty lack -lustre performance by the DSM team. Male contributors to this forum may have noticed some other beneficial advantages to improved bloodflow. Just imagine if the Chinese, for example, got knowledge of that! They could dispense with the ground Rhino horn which would be of immeasurable relief to the poor old Rhino. Could not DSM have alluded to that benefit when discussing blood flow without actually mentioning ED? Many other companies allude to an attribute of their product without having to show scientific data.
"Isn't Bi Health a 3 way split? DSm/Bi Heakth/Pxs"
Not that I am aware of.
And what year will Bi Health do this? Isn't Bi Health a 3 way split? DSm/Bi Heakth/Pxs
Rather horrifying article in the telegraph
https://www.telegraph.co.uk/global-health/science-and-disease/revealed-coronavirus-attacks-veins-heart-brain-blood-lungs/
W!
Not saying our day has come. but we're somewhere in the fortnight leading up to it i think.
just hoping that there is no backlash against china in the short to medium term that slows progress there. just saying it, if your thinking ahead youre probably thinking it anyway.
Wait till bi-health get blue cap and release multiple products with FF. I see it's your first post. Been holding long