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Hillseeker,
The RNS states
"Novacyt's genesig® COVID-19 assay was launched on 31 January 2020 and was one of the world's first commercially available tests for COVID-19. To date, the genesig®COVID-19 test, which targets the ORF1ab gene, continues to be able to detect all known variants and mutations of COVID 19, with over 4.5 million sequences analysed, as documented in Novacyt's latest weekly bioinformatic surveillance report."
It's the original 1 gene test that has been approved. By my maths we have 1 approved and 1 exempted from 11 submitted. Want to see which ones are pending and hopefully not pending for long!
Well the Cardiff Rugby team is unable to leave South Africa after a suspected Omicron case :
https://news.sky.com/story/covid-19-cardiff-rugby-team-unable-to-leave-south-africa-after-suspected-omicron-case-12481471
Munster Rugby, one of the rival teams also being held back.
If this new variant is mild then why the massive increase in hospitalizations :(
https://twitter.com/DrEricDing/status/1465037954783621131?s=20
@DRB
- OK, I understand you question now. You are thinking that the S gene has mutated (deletion of amino acids 69 and 70 within the spike) and is not entirely missing. I thought the Omicron mutation has no S gene, but I may be wrong. If that is the case the extract below would suggest you are right as some tests would not pick up the S gene, whereas others would. So, we're not any cleared I'm afraid.
"Deletion of amino acids 69 and 70 within the spike (S) gene of SARS-CoV-2 B.1.1.7, sometimes attributable to the N501Y mutation, can result in an undetectable S-gene target (S-gene target failure, SGTF) for some real-time reverse transcriptase polymerase chain reaction (RT-PCR) testing methods. A rapid increase in the proportion of SARS-CoV-2 samples with SGTF was identified in regions of England affected by B.1.1.7, and, after validation with whole genome sequencing, SGTF was determined to be a reliable marker of B.1.1.7 across the country."
Taken from https://jamanetwork.com/journals/jama/fullarticle/2778599
That is the problem with sequencing. It takes 2 weeks. The first case was picked up from a sample dated Nov 9th. The variant was identified in the 24th. So let's assume that this strain has been passing freely along with the Delta variant around the world. Wouldn't take long really.
As for the rugby. Pretty safe bet to assume Omicron is well bedded into the fabric of the UK society by now. Regards
Could well be right Kaeren.
Many think the Champions league football match in Liverpool in (March?) 2020 vs. Spanish team caused the outbreak in the North west.
Hillseeker, thank you and I was aware of the 3g test looking for the s gene. However, it is still not clear whether the mutations in the Omicron s gene would cause the Genesig 2 or 3g test to pick up the drop out. Earlier research found that the Thermofisher test would pick up on the missing 69/70 elements of the s gene where as the Genesig test would still recognise it as the s gene. Very complicated and scientific but at least it gives some food for thought to the ncyt R&D team for the next test.
The SNPsig for the Omicron will be huge if we can develop one next week. Crest of a wave.
I would think there would be a good chance that at least 1 person visiting from South Africa for the rugby in London last weekend would have been infected. If it is as contagious as they say, watch this space.
On a side note. The first reported case in Europe involved a person who hadn't been to South Africa. They had recently been in Turkey & Egypt. Who & where did they contract it?
Well it makes it worse KT , there must have been many positives at Twickenham mingling , UNLESS the one week earlier meant the spread hadn't yet started ?
cut off again!
@ Porky – yes, sentiment is hugely important and is increasingly overtaking fundamentals as a key driver for SP, especially on AIM and particularly stocks such as Novacyt where there is huge PI interest.
However, information is king, and the situation is fluid, so it is important to stay abreast and be as informed as one can possibly. Is that not the purpose of this BB?
For those that haven’t watched it yet, today’s Marr Show is worth a watch:
https://www.bbc.co.uk/iplayer/episode/m00123k0/the-andrew-marr-show-28112021
Includes Dr Paul Burton from Moderna and Dr Angelique Coetze, the South African Doctor who first identified the new stain due to a change in her patients’ symptoms.
The key take-home was from Sajid Javis though:
“Government and private labs will all be required to test for S gene dropout!”
They are using the S gene to screen for Omicron. The Beta virus and other mutations also have S gene drop out, but as 99.9 % of cases in the UK are Delta, which has the S gene, any S gene dropout is likely to be Omicron. Further sequencing would then be required to verify.
The requirement comes into force as from 4:00 a.m. Tuesday. (All inbound passengers are to self-isolate until PCR negative, there was no mention of day 2)
@DBR/RBM Invest
For your information, the way the genesig® 3G works is as follows:
It targets 4 genes, Orf1, S, M and a control gene. To be PCR negative you have to have a positive control result and the remaining three negative. (If all four are negative the test is not valid and needs to be re-run.) If any of the other three genes (Orf1, S, M) are shown positive either on their own or in combination with the others then the sample is considered PCR positive. So genesig® 3G can be used to detect S gene dropout.
Clearly, it was fantastic news that he Company's genesig® COVID-19 Real-Time PCR test has been approved in the UK and added to the CTDA list (one of only 7). It is unclear as to whether this is an umbrella term and includes genesig® 3G and genesig® 3G HT. I suspect these additional two tests are amongst the remaining eight Covid tests waiting for CDTA approval.
I hope this is of some help.
As Karen says, though, this is only affecting UK sales and I would expect us to be struggling to keep up with demand from elsewhere during the current circumstance and it will only be a mater of time before all remaining tests are approved. It won’t be long until Omicron is added to SNPsig®. This will save on expensive and time-consuming full genomic sequencing to verify all positive Omicron suspected cases. So, expect and RNS for that too at some point soon.
Back to Porky’s sentiment: I’m looking forward to the action this week. Things are looking very positive – the sun is out, and we can see the mountain glistening ahead, looming large. Are you ready for the climb?
GLA
@ Porky – yes, sentiment is hugely important and is increasingly overtaking fundamentals as a key driver for SP, especially on AIM and particularly stocks such as Novacyt where there is huge PI interest.
However, information is king, and the situation is fluid, so it is important to stay abreast and be as informed as one can possibly be. Is that not the purpose of this BB?
For those that haven’t seen it yet, today’s Marr Show is worth a watch:
https://www.bbc.co.uk/iplayer/episode/m00123k0/the-andrew-marr-show-28112021
Includes Dr Paul Burton from Moderna and Dr Angelique Coetze, the South African Doctor who first identified the new stain due to a change in her patients’ symptoms.
The key take-home was from Sajid Javis though:
“Government and private labs will all be required to test for S gene dropout!”
They are using the S gene to screen for Omicron. The Beta virus and other mutations also have S gene drop out, but as 99.9 % of cases in the UK are Delta, which has the S gene, any S gene dropout is likely to be Omicron. Further sequencing would then be required to verify.
The requirement comes into force as from 4:00 a.m. Tuesday. (All inbound passengers are to self-isolate until PCR negative, there was no mention of day 2)
@DBR/RBM Invest
For your information, the way the genesig® 3G works is as follows:
It targets 4 genes, Orf1, S, M and a control gene. To be PCR negative you have to have a positive control result and the remaining three negative. (If all four are negative the test is not valid and needs to be re-run.) If any of the other three genes (Orf1, S, M) are shown positive either on their own or in combination with the others then the sample is considered PCR positive. So, genesig® 3G can be used to detect S gene dropout.
Clearly, it was fantastic news that the Novacyt's genesig® COVID-19 Real-Time PCR test has been approved in the UK and added to the CTDA list (one of only 7). It is unclear as to whether this is an umbrella term and includes genesig® 3G and genesig® 3G HT (or the "G version for that matter). I suspect these additional tests are amongst the remaining eight Covid tests waiting for CDTA approval.
I hope that is of some help in clarifying.
As Karen says, though, this is only affecting UK sales and I would expect us to be struggling to keep up with demand from elsewhere during the current circumstance, and it will only be a mater of time before all remaining tests are approved. I strongly suspect we will be making a claim for any lost revenue against UK Gov anyway.
It won’t be long until Omicron is added to SNPsig®. This will save on expensive and time-consuming full genomic sequencing to verify all positive Omicron suspected cases. So, expect and RNS for that too at some point soon.
Back to Porky’s sentiment: I’m looking forward to the action this week. Things are looking very positive – the sun is out, and we can see the mountain glistening ahead, looming large. Are you rea
At Schiphol out of the 61 positive cases on the 2 planes , 13 confirmed as omicron .
I can't get my head round tracing contacts of third known positive case ( since returned to S.A )
What about the thousands of South Africans who were at Twickenham last weekend. I believe 80, 000 capacity. Then look at the two flights from Schiphol with 10 % of passengers positive ( don't know what variant) what is being done about all those individuals at that game, many still probably in the UK. What am I missing here ? We are hearing about track and trace of contacts of one , there are thousands ?
https://www.theguardian.com/world/2021/nov/28/coronavirus-new-restrictions-omicron-israel
Certainly serious measures being taken to control the spread.
Israel barring entry to all foreign nationals and red-listing travel to 50 African countries and using phone monitoring technology.
Yes, some even spend billions of our hard earned cash on Chinese binworthy crap.
And/or have more than a friendly realationship with Putin.
Oh and even encourage others to storm their own democratic institutions etc.... etc...
Why be sensitive, all this ****e started in China
Not one leader in the western world has the cojons to stand up to them. It is times like this that I miss Donald.
Certainly not villifying the whole of the African continent !
Think all of the media have been much more sensitive in the use of the Greek alphabet as opposed to identifying variants by country. Of course, I can understand SA's position regards travel restrictions and there may some concern that other countries don't come forward as quickly, as a result.
28.11.21
WHO is urging countries to take key steps to enhance efforts to track the Omicron variant, including ensuring their PCR testing equipment can detect it, increasing their sampling and sequencing of COVID-19 test samples by at least double to 150 samples a week from the current average of 75, and review past sequencing samples for potential signs of Omicron.
Https://reliefweb.int/report/world/who-stands-african-nations-and-calls-borders-remain-open
So bored of Porky conversations. Exciting times for Novacyt 'Our investment'
Without doubt Genesig received validation for a reason. All hands to the pump , a selection of tests will undergo full genomic sequencing. No singular test will be able to supply the global demand. Yes we await 3G approval and the August release of Promate ( I think )
In the interim be mindful any restriction on sales is purely UK based on non approved tests yet ( what I call a right feckin home goal BJ) After our global road shows I am in no doubt that Novacyt will be in demand as will all PCR tests. At the best we can hope for more transmissable and less serious medical implications ( no mention yet of long covid ) and at the worst back to square one.
Please note, I am not denying the Omicron variant. I just believe that China is being let off the hook.