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For FOMO Friday, there seems a hell of a lot of sells compared to buys today. Bargain price of the day has to be this one below. NOT!!!!
Was it really worth it??? How awful it would be if we had a peach of a RNS on Monday. Have a good weekend all
19-Apr-24 08:12:51 1.587 750,000 Sell* 1.642 1.67 11.90k
HEMOTRUTH'You should have purchased SUPERDRY 😆
Boy it’s felt a long 10 weeks too….
Website sorted, so you might be onto something.
When the news breaks, new potential investors will see a nice updated website.
That can only be a good thing.
It been 10 weeks since the FDA gave approval for clinical trials.
Surely we will hear soon from the company as to when these are about to actually commence.
Hilver maybe the "I won" tweet by VS a few months ago was in relation to his wish to notvwanting a spin off Bait Technology strategy.. Prevail were in the presentation room when this was first brought to our attention and they were particularly vocal at the end. They've been conspicuously silent since as you rightly observe. Let's not complicate things Hemogenyx, just prove CAR T working in P1, get some JV money in for ALL of Hemo's pipeline (the website now sets them out) and use it to advance CBR in parallel. Yes EOY Report awaited eagerly. GLA
Chris, that's very interesting and I hope you are right. There has been a notable absence of Prevail either in the CH lift RNS nor any of the interviews or other media reports published since. Neither did Prevail issued anything of a congratulatory nature to promote Hemo on the CH lift on their media outlets.
Maybe Hemo board didn't like the way things seem to have gone over at BriaCell Therapeutics since Prevail's invested $4m as lead investor in its funding round. The subsequent spin out of one third of that company's pre-clinical assets, which was proposed prior to the funding round but only approved after, to a new company BriaPro, has seen BriaCell Therapeutics' share price drop from $6 at the time of the funding round (May 23), $7 just prior to the spin-out (Aug 23) down to around $2.15 (today); though the investors would seem to have received shares in BriaPro - but that's an unlisted reporting issuer in Canada.
Awaiting the Annual Report with interest.
Nothing in there that we didn't get up to in Mr Jenkins' Yr 5 science class ;)
The bait terminology is applied to the antiviral solutions CBR - chimeric bait receptor which appears to be the direct manipulation of macrophages to express viral entry protein ie what virus binds to to gain entry into the cell - thereby giving macrophages the ability to directly bind and destroy the virus while processing and informing other immune cells. BME bait macrophage engager appears to be a macrophage engaging protein attached to the bait viral entry protein - so instead of directly engineering the macrophage it is one step removed - virus binds bait then macrophage binding arm binds macrophage receptor. CMR - looks like directly engineering macrophages to express an ScFv (engineered binding domain of an antibody) which is raised to bind a specific tumour antigen. AME is one step removed ie a protein with an ScFV binding domain on one side and a macrophage engager on the other (or mRNA which is the template or set of instructions for the cells to make the protein themselves). - see diagram https://hemogenyx.com/technology/ although I am not sure if the headers for this diagram are mixed up re biologic and cell based therapies
Thank you!
Yes - CMR: Chimeric macrophage receptor, CBR: Chimeric bait receptor, BME : Bait macrophage engager, AME: antigen macrophage engager
Anyone know what CMR is?
Closing price 1.664
Vol 11.6 million
Big Friday RNS would suffice 👍
Impressive buy and some nice movement north. It's surprising what difference updating their website does. All we need is a decent RNS now ;)
18-Apr-24 16:00:11 1.684 1,500,000 Buy* 1.612 1.644 25.26k
Vol 11.5 million
Need stronger vol to move north however a positive RNS update would suffice ..
Someone’s tossed a wedge in - nice kipper buy
18-Apr-24 16:00:11 1.684 1,500,000 Buy* 1.612 1.644 25.26k
£1 party?
You were crying about missing the 6p party a couple of days ago
Still waiting on that £1 party 🥺
Haha! This is great, got a nice feeling and I'm glad the information for the tech and pipeline has been updated :)
Reference to CDX Phase 1 'expected 2025 - 2026' - that's new.
Not sure that all the biographies are current - more people to be added too maybe.
Yeah website is very nice to browse around now, good to see the people involved.
Looking at the pipeline it seems CDX is ahead of CBR, if its accurate.
I think I've been rumbled by Haywain! (Keep up the good work) GLA
Ha ha, Well, Chris, you've certainly taken us through a quantum leap with that explanation! Just when we thought biomedical acronyms were the toughest nut to crack, you've woven in the fabric of quantum theory, threading through entanglement with the ease of a Schrödinger's cat straddling worlds. With each mention of "absolutely maximally entangled," you've not only entwined particles but our minds, leaving us in a superposition of both understanding and bewilderment. Now, if only unraveling the mysteries of Disease X were as straightforward as a quantum entanglement puzzle!
It does look great. Long overdue. I've just shared a post about them updating it, along with a link to it, on my LinkedIn feed. The last post I shared there had over 50000 views, so I'd settle for this even just having a fraction of that 😅
To the rescue Haywain .... The absolutely maximally entangled (AME) state is a concept in quantum information sscience, which many applications in quantum error - correcting code, discrete Ads/CFT correspondence, Ads/CMT correspondence, and more. It is the multipatite generalization of the bipartite maximally entangled state. Hope we are all clear now. (That was part of my FFS construct)
Jeepers do I have to sort everything out!!!!
Ok ignore that - found explanation https://hemogenyx.com/technology/