Roundtable Discussion; The Future of Mineral Sands. Watch the video here.
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'Can we entertain the possibility that if there were no Tumours in the targeted body to activate it, could it simply stay dormant in that body for a long time / or even a lifetime until it found a Tumour to activated it ?
Meaning this technology could also be adapted to act as a Cancer Vaccine ?'
Given that the drug would be cleared out in hours and days rather than weeks and months (Renal clearance (CLr) of AVA6000 & Doxorubicin [ Time Frame: Cycle 1 and Cycle 2, 0-72 hours post dose (Dose Escalation) ]
CLr (Renal clearance) of AVA6000 and Doxorubicin after administration after Cycle 1 and 2 for 72 hours post-dose.) it seems hard to imagine it hanging around as some sort of inhibitor but maybe people could use it as a prophylactic every few years, perhaps when people reach their fifties and are generally past the age of having children.
Having said that, if it's as effective as we hope, would there be a need? Just get treated when you need it.
It actually sort of comes down to this….. if it works (IF, not when) then does anybody know of a share that can produce the kind of rise we will see here and do you have the time and finances to hold on?
Seems to me that considering the considerable headwinds they faced in actually getting the LFT to market, and the fact the likes of NCYT, ODX, ABDX, BRH etc all faced similar headwinds including none payment that it was always going to be a losing battle. That’s the difference with AVA6000, the MHRA actually gave us the green light ahead of time to proceed to clinic with zero causes for concern. We’re in a totally different situation now. It’s a totally different kind of market; we aren’t competing against inferior imports as we were against innova or a scandal of the PPE sort. If you take the positivity of the Avacta team and the fact the trial is ongoing, it’s clearly going well. If you compare it to the delays with the LFT then you’re comparing two scenarios that are wildly different; we aren’t working on a product that’s being sold into a diminishing market and against a waning public enthusiasm (for testing), we’re developing a treatment for a disease that’ll probably never be gone.
All this requires is patience. And a hobby to help stay distracted while we wait.
:) EGTP - I too hope and do believe they’ll fix it and confirm it works. This time with Affimers. Not convinced on the market, but positive either way.
I'd like to go back to the interesting links that actually kicked off this thread please.
In the oncology YouTube Amy Turner, who is working for Darren Tomlinson at the Leeds Astbury Centre for Structural and Molecular Biology, says she is developing affimers to link with RAS protein in cancers, which she hopes will result in news ways to treat, for example, pancreatic cancer. In passing she says she would welcome industrial support/sponsorship - something of that sort.
Avacta’s website says the Affimer® platform is Avacta’s proprietary therapeutic platform with its intellectual property covered by several patent families.
Can some kind soul who understands these things better than I do explain whether or not, or how and to what extent, Avacta would or would not (!) have some sort of first refusal on new therapies of this sort?
No problems at all beinthelead - I didn’t for one second think you were, just one of many reaching out from pure frustration, there’s a good crew on here plenty of honest well researched input and conversation, so don’t let an old fart like me upset you !
For me I do expect a revised bullet proof AffiDX SARS Cov test to re-appear soon, plus other AffiDX tests to detect Cortisol Vitamin D Sepsis Cancer ect to follow, because the potential world wide saving in costs, man power and lives from LFT self testing diagnostics is beyond colossal.
Be in no doubt this is future multi trillion dollar industry in the making, as a direct result of coronavirus.
One interesting thought I can’t get out of my mind - if AVA6000 is as now stated by Avacta to be solely ‘Tumour Activated’
Can we entertain the possibility that if there were no Tumours in the targeted body to activate it, could it simply stay dormant in that body for a long time / or even a lifetime until it found a Tumour to activated it ?
Meaning this technology could also be adapted to act as a Cancer Vaccine ?
DYOR
Hi EGTP. I don’t mean to sound arrogant by the way, just my view. Agree we must move forward. Looking forward to July.
Thankyou beinthelead - but with respect Omnicron did not exist in April 2021 when Avacta had the most accurate LFT in the world, so by logic no other test in the world could detect Omnicron at this time either.
It wasn’t until December 8 months later that Omnicron appeared and it was only then that avacta (like many other tests on the market) found it could not detect Omnicron with at least 99% accuracy, this due to its very specific targeted design - hence its suspension, this unfortunately was the correct thing for Avacta to do.
The reason it not achieve massive sales to compete with the already established Tests was because it simply arrived too late, mainly due to the initial more advanced focus on ‘a saliva test’ which the Uk government were very clearly leaning toward, before then changing their minds in early 2021, also the unexpected incompatibility delays with another 3rd party Avacta initially worked with Adeptrix
So the avacta LFT at that time was the best in the world, and yes many development factors were out of their control which led to its delay, meaning it didn’t live up to the market’s (not avactas) expectations - which was a massive blow to us all
But onwards upwards - if AVA6000 is as good as the expectations / indications of Avacta (clearly not the markets) Well we should really be heading for the stars !
GLA - DYOR
Timster - if you bottled your sarcasm, I’d be buying.
I'm shocked wressmycash
No problem.
It wasn’t the most accurate in the field as it was unable to detect omicron, while others were. We were never told how ‘ineffective’ it was, therefore I assume, not very.
Sales - they didn’t achieve any. Others had loads. This was almost entirely out of there control and we were shafted.
Beinthelead - avacta finally delivered what was at the time the most accurate easy to use LFT in the world with 99% accuracy April 2021 ish.
AS did state in 2020 that they would sell as many as they could make, and this was certainly the expectation at that time, as there simply weren’t enough tests available to get the world out of lockdown.
But in all this time and even after the tie up with Medusa19 - AS never once stated they would do anything more potentially than sell millions monthly (check the RNS’s) it was only us the market that thought / believed differently
So can I respectfully ask how you come to those conclusions ?
Best Wishes
DYOR
EGTP - They didn’t deliver on a gold standard LFT, nor on the sales expectations.
The benefit of the LFT fiasco was the LFE and QMS to deliver future diagnostic products.
I posted that on Twitter gmcc
Nice reminder courtesy of twitter , a study from Leeds University last year video - Obviously takes a very long time to move projects from the lab though to commercial reality , Leeds University an outstanding scientific resource coming up with novel applications .
This just one j of the very many potential use of affimers . "New treatment approach targets cancer 'Death Star'
https://www.oncologytube.com/video/40048/amy-turner-phd-amyturn67763683-tomlinson_lab-astburycentre-scienceleeds-ras-rasprotein-affime-cancer-research-new-treatment-approach-targets-cancer-death-star?channelName=cancernewsupdate#gsc.tab=0
https://twitter.com/oncologytube/status/1420463257131753472?cxt=HHwWgICpnc7zv7YnAAAA
https://healthcare-in-europe.com/en/news/new-treatment-approach-targets-cancer-death-star.html