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Dr A Fauci: "Viruses are will creatures and you have got to stay ahead of them. I think it would be naïve to think that if you get one or two good drugs, you don’t need any more — not when you have a virus that has already killed 760,000 Americans."
What nonsense “How long can SNG be the exception”
For as long as it’s the only viral agnostic capable of treating people in hospital
That’s how long and as the the rubbish about Omicron and herd immunity. That’s what they were saying about Delta and then Omicron came along and we discovered Delta didn’t give you immunity against Omicron.
These threads by trolls are utter nonsense
The government is removing all restrictions and by march, you will not have to self isolate either, which means no more free tests.
Hence why all the testing companies plummeted you have just proved the point synairgen is vastly different.....
There are around 1000 testing companies...how many in hospital covid therapeutics with FDA eua approval or about to apply? a handful? look forward to your response to this point..... A price of one test is £7 (this is the average cost sold from manufacturer). Synairgen course is going to be around 2k-3k....happy to help
Average hospital cost for basic hospitalisation is 30k to 120k and severe 120k to 320k...all the figures are out there to look at.....
YEP you are so right ..............
Noooooooooooooooooooot
Mumbo, NRX went down 12% yesterday. They’re trading below 4 dollars now.
Didn’t you see the latest RNS? Zyesami will be offered to patients as an experimental drug who have failed to recover with first choice Remdesivir.
Did you not pay attention to see what their latest adapted EUA was about? It was asking the FDA to approve Zyesami ONLY IN patients who have failed to respond with Remdesivir.
They just announced yesterday that this is going to happen, then SP plunged 12%.
I told you in our discussion, the money with NRX is with their vaccine, not with Zyesami.
If Synairgen works and is released, there is no need for Zyesami at all. Hence why NRX were frantically scrambling an application to the FDA because they know they have limited time. They only have data from 230 patients in a Phase 2 trial and are waiting on ACTIV 3b (scheduled to complete in December).
I don’t know why you’re so defensive. I have holdings in both SNG and NRX. However my holding in SNG is around ten times the size of my NRX holding.
gggg21- We are awaiting the P3 results not EUA. The EUA process will be months after and by that time, omicron would have swept through much of the western world.
Eua could be granted instantly, so your argument is baseless.. no point discussing if the results aren’t good.. but if they are good and significant, then emergency use will be given shortly after just like the did with other treatments
Mumbooo...how long from results to order from gov was pfizer pill? look forward to that answer as they ordered before eua approval and eua approval did not take months. Again happy to help you.
PS most of pfizer pill is not being delivered until the summer in the US and only two weeks ago biden ordered another $4bn as they want to stockpile for autumn....
What about the next variant mumbo...
Mumbo, what’s your point?
So what if Omicron has swept through the world?
So did Wuhan, Alpha, Delta etc.
What’s this fascination with Omicron? Come March/April there will be a new variant. Then six months after that another new variant.
Who cares about Omicron? Covid 19 is not going to suddenly disappear. Has the flu disappeared? Have colds disappeared? Has pneumonia disappeared?
I don’t understand this fascination that if Omicron goes around the world, then that’s the end of covid?
If it goes around the world there WILL be a new variant that emerges and it all begins again.
My green bin is filling up nicely with the mumbo-jumbo you are spouting!
GLA
previous infection + vaccines will provide a great barrier to severe disease outcomes
Can you answer any of my questions mumbo? You are going off on any tangent necessary, what has got you upset?
Vaccines wane after 10 weeks, natural immunity wanes too....
Again what about the next variant....why are vaccine makers getting new vaccines made....
Your arguments are incredibly weak probably like yourself ;)
Mumbo Jumbo is spoken nonsense.
Therefore I applaud you for espousing a view which is just that.
Sigh. I'm filter binning him.
This bull@@@t run is over for me.
This was a very small trial and had complications which i will not go into here. Folks can read the detail in many published articles, if they so wish. Mene Pangolos decided it was not worth pursuing, and a few other drugs at the time, which have since proven to be successful.
In 2016 after AZ dropped the Phase 2a study Professor Stephen Holgate said:
“New treatments to prevent severe exacerbations are needed and most exacerbations are caused by the common cold and flu. Unexpectedly, colds did not cause as many asthma exacerbations as were predicted in this clinical trial population. We hope to learn from the results of this trial which population within severe asthma, or other respiratory diseases, will most benefit from AZD9412 and should be included in future trials.”
Synairgen have learnt lessons. Delta spread through Western world..........Omicicron is spreading through the western world...........
Endpoints have been carefully choreographed for SG018 in breathless patients, more specific than in the P2. I believe the signs a strikingly optimistic, notwithstanding, all we have learned from the P2 and dissected to death (see Lancet)
They know the results already for P3 and have already advertised for numerous positions in the USA and strengthened staff substantially and set up many agreements ready for potential launch.
Tick tock
GLA.
Hoooooooooooooooooooooolllllllllllllllllllllllllllllllllldddddddddddddddddddddddddddd.
Tbh Mumbo, I’m beginning to think that you never invested in SNG or NRX now.
It’s interesting that you came on here last week saying that NRX has much more potential market than SNG does.
Subsequently NRX sinks 12% and looks like it’ll go down further, with their market being squeezed tighter and tighter all the time (hence their desperation to get EUA after the first rejection because they haven’t done a full phase 3 trial).
But apparently you have a holding in SNG as well. I don’t understand why you’re not happy?
As I have to keep telling you, SNG001 is not just about Covid, it’s for ALL RESPIRATORY VIRUS’.
It is similar to Heberon in Cuba which has been used for the last two decades. It’s has total multi utility.
For some reason you can’t seem to grasp this.
Western governments will need to stockpile SNG001 Interferon beta to protect against new variants of Covid AND completely new respiratory virus’ (seeing as they emerge every decade or less). It will also be used in asthma and COPD patients. The latter is where Synairgen will either be taken over or have a joint venture with big pharma to develop SNG001’s utility for asthma and COPD.
This is a needed drug. Whereas Zyesami is not so much needed.
I see Dimbo-Dumbo is back then!!! Yawn........
I wouldn't worry about that NDN. They worked with the FDA to agree on the protocol and others on here that are much more familiar with trial design than either of us (such as mattml) have covered this repeatedly that the P3 trial is sufficiently powered.
NDN - It's always good to be cautious when investing and check you're thinking for confirmation bias. It does feel that the company is exuding confidence on a scale we have never seen from them before in the past. If lukewarm or poor results were incoming then I think comms would have been non existent or minimal - plus they wouldnt be splashing out on new US websites, origin videos, signing new partnerships and posting half a dozen US job opportunities.
I think we can sleep comfortably (albeit impatiently) until P3 results are announced.
NDN, that scenario you describe of not enough trial participants to give meaningful results is extremely unlikely.
Synairgen will have been in liaison with the FDA prior to the start of SPRINTER. They will have been told that 610 trial participants was enough.
"I haven’t just thought this up"
No kidding.
In fact, if I recall correctly, I specifically read that the FDA were the ones who told Synairgen that they can go to 600 patients instead of 900. Synairgen then decided on 610 patients (I don’t know why the extra 10, perhaps just in case some results get an N/A).
It might have come from one of the RNS’ that Synairgen initially released pre commencement of trial.
I think the extra 10 were to cover anyone who signed up for the clinical trial but failed to see it through, dropping out for whatever reason. It happens. 10 extra would be a decent % over and above to cushion impact of that.