Member Info for Wildforce

From research paper ..

"Brief electric pulses induce a transient increase in the permeability of cell membranes, resulting in enhanced plasmid DNA uptake and protein expression levels.65 In addition, EP is largely thought to provide an adjuvant effect with local tissue damage and subsequent expression of pro-inflammatory cytokines."

Fascinating stuff !

Take care all ..

Just reading through the research paper I posted.. I'm not sure whether nanovesicle delivery would produce an improvement over electroporation ? Despite it definitely being considered..

One facet of success to date is actually the trauma caused by the electroporation delivery itself !? Now whether this was by design or something deduced through the scib1 trial , I'm wondering how a nanovesicle system would replicate this 'trauma' ?

Fascinating watch though eh !!

Take care ..

The paragraph pasted twice !? Oh well, worth reading twice for good measure lol!

Take care all ..

The previous link I posted may have been of interest to nomlungu who has a fascination with the above ! Wouldn't it be interesting if Lindy and her team were well aware of it !? Even more so .. that it was one of the many facets of immunobody that have produced such beyond expection results !?

"A novel DNA vaccine approach encodes the specific T-cell epitope within the CDR region of an antibody. The constant fragment crystallizable (Fc) region of the antibody targets the high-affinity Fc receptor CD64, which is only found on activated and not immature APCs.47,77 The DNA is administered with EP which ensures good transfection, but inclusion of T-cell epitopes within the CDRs disrupts the antibody folding and leads to production of low levels of antibody. This results in higher-affinity CD8 responses than whole DNA vaccines, peptides or peptide-pulsed DC vaccines.A novel DNA vaccine approach encodes the specific T-cell epitope within the CDR region of an antibody. The constant fragment crystallizable (Fc) region of the antibody targets the high-affinity Fc receptor CD64, which is only found on activated and not immature APCs.47,77 The DNA is administered with EP which ensures good transfection, but inclusion of T-cell epitopes within the CDRs disrupts the antibody folding and leads to production of low levels of antibody. This results in higher-affinity CD8 responses than whole DNA vaccines, peptides or peptide-pulsed DC vaccines."

Scancell... putting theory into practice!?

Take care all ...

Interesting science .. But the thing with scancell is ... It's being put into practice !

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933538/

My money is on Lindy and her team to make the science useful ... Top up coming up !

Take care ..

And should the findings of the scib1 / keytruda combo in late stage unresectable melanoma be as the science suggests ... well .. is keytruda is paving the way ?

https://www.pharmpro.com/news/2018/07/keytruda-first-anti-pd-1-therapy-approved-china-advanced-melanoma

Take care all ..

As Hygea know what we all know and nothing else, if the grand challenge is not such an event, then out of interest, what do people think is !?

Starting trials, patents, trial updates, and new technology have happened and are not liquidity events demonstrated by history ... so what else that we are expecting this year is !?

Interested in all your suggestions!

Take care all ..

'Liquidity event' suggests some sort of cash involvement ?? Could be a reference to their expectation on Grand Challenge result perhaps ?? Who knows !

Take care ..

I believe its 31st December looking under the financial diary tab on their lse page ..

Take care ..

"We have reviewed the valuation of our unquoted portfolio and do not believe that any revaluations are necessary but overall we remain pleased with the development of that portfolio.

I have previously expressed some optimism regarding potential liquidity events in the portfolio and your Board remains of the view that such an event may occur before the Company's year-end."

Fingers crossed eh !

Take care all ..

Yep .. you on it !

Also a hygea RNS this morning too..

Take care ..

Shares linked to Ichor worldwide licence of trigrid v2.

Take care ..

Flex .. (formerly known as Flextronics) ..

These are the folk that helped design the tri-grid system v1 and v2 ..

Had a little surf of their updated web pages .. quite some company !

Thought this was interesting .. I guess it's not straight forward creating futuristic electro-mechanical devices ?

https://flex.com/insights/case-studies/healthcare

Take care all ..

A very quiet period indeed .. Not much to say but thought this of interest re Oxford science park ..

https://www.gov.uk/government/speeches/britains-new-unique-selling-point-usp-the-go-to-place-for-science-and-innovation

Take care all ..

You may find this of interest if you havnt seen it before of course ..

https://www.scancell.co.uk/file-manager/scientific-papers/pivac-scib1-plus-checkpoint-inhibition.pdf

Take care..

Yes, my family were involved in the 100,000 genomes project through GOSH.

Very happy to help in any way we can !

Does your issue extend to scancell at all ?

Take care ..

Nomlungu .. I have some experience via my wife .. she went on a trial for sibling groups of more than 3 who no longer had a living relative with suspected brca1 ... her mum and grandmother both died at 47 from breast cancer ..

The results were a bit bitter sweet .. only one of the four of the siblings had brca1 ... unfortunately the unlucky one is my wife !!

Despite the trial being effective and 'successful' for us (all risk reduction options taken) .. my wife is 49 and to date as far as we know clear, the screening method has been shelved as it wasn't considered commercially viable !

Is that better for all ??? I'm not sure ...

Options are always better than no options in my opinion ..

Take care all ...

That's an interesting issue ! Arguments all over the place there ..

Which specific part is relevant to scancell ?

Also pi really isn't that complex .. it's simply the relationship between the diameter and circumference of a circle and is a constant no matter what size the circle.

Take care ..

I have yet to find another biotech company that tries to explain its science to investors in quite as much depth as scancell ... but of course, you need to concentrate or you'll quickly not have a scooby doo what they are talking about !!

As Inanaco says .. it's super complex but the bod DO try and inform as clearly as possible !

Take care ..

.. and the resultant 'ultra high avidity' of the t-cells means they dont go after 'self' cells !

Exemplified in scib1's safety profile !

Exquisite..

Take care ..