Member Info for Wildforce

Modi1 recruiting up to 144 participants .. so should get some more data fairly soon ..

Take care ..

Depends I suppose on speed of recruitment? And percentages seeing tumour shrinkage and/or associated side effects?

My guess is if there is some shrinkage seen in 30% plus patients with few side effects, I don’t see how modi1 couldn’t see accelerated approval in groups that have run out of options at least!?

When ?? That’s the big question .. this time next year perhaps Rodders lol !

Take care !

Tumour shrinkage is a surrogate endpoint for accelerated approval .. could be an interesting year ..

Take care ..

Indeed .. on the edge of my seat awaiting any news from particularly those two cohort 2 patients who also had an early immune response!

Take care ..

I must have missed this update but nice to see the swimmer plot on the web page and an explanation of the upgrade to iscib1+

https://www.scancell.co.uk/scib1-iscib1

As LD said at the agm .. it’s greatest improvement is that it has the potential to work in all patients!

Take care all ..

Ok ..

Take care ..

Thanks berm ..

Take care ..

Oops forgot the ‘reply’ button again on that one lol my bad !

Take care myself ! Lol ..

Scancell have clearly reported previously on individual patients ‘during’ trials .. I think those are the ‘results’ being referred to and not the formal reporting at the end point of a trial or phase?

Take care ..

Sorry .. completion of which trial ?

I think particularly with immunotherapy trials there is a tail to the trial which consists of data gathering and analysis?

Whilst we know the Covidity phase 1 trial has indeed ‘ended’ ie no longer recruiting, the conclusions from the data (if any) are still being sought ?

But the modi1 and Scib1 trials are on going .

Would indeed be great to get an update soon though on one or all ?

Take care ..

Morning ! Now that would be something !

I must say this period of quiet is intriguing!? We know there is quite a bit of news due !?

Also .. I was a bit underwhelmed by what has come out of the JP Healthcare conference this year .. ?

Take care all ..

Ah ok ! Thanks .. your last point is very interesting!

Take care ..

April 22 .. so more updates due soon ..

https://www.trinitydelta.org/research-notes/a-fresh-impetus-in-delivering-immune-oncology-vaccines/

Take care all ..

Konar .. quote from the trinity delta report ..

“ The AvidiMab platform is being employed to increase effectiveness, and extend the patent life, of the Immunobody programmes.”

It’s quite an in depth report and I’m sure most of you will have read it.

Thanks for the comments berm ..

Moditope was a serendipitous discovery .. I think the human eye is more likely to come across such things than AI ? But that’s only my opinion.

Take care all ..

It’s intriguing isn’t it … what are all these AI machines and computers looking for !?

Biological processes that are occurring within cancer cells that the immune system could recognise perhaps?

Also .. that AI is all the rage , suggests to me that they all haven’t found anything yet ?

Just some thoughts as ever ..

Take care all ..

Welcome JM ! Let’s hope your arrival on the bb is a good omen ! Lol ..

Let’s hope good news isn’t much further away .. another ten years might even test my patience ! Lol ..

Take care ..

Thanks for the observation .. was talked about on here yesterday ..

Take care ..

Referring to this From cleaners link this morning ..

“ At the 2023 J.P. Morgan Healthcare Conference Tuesday, CEO Ugur Sahin, M.D., disclosed that the company was working on a modified COVID vaccine that combined the spike protein seen in past versions with T-cell enhancers. ”

Sorry for any confusion ?

Take care ..

Yes.. but just referred to as targets from previous spike protein vaccines ?

Take care ..