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Violin , interesting piece .. Lofas, it’s mostly stuff that’s been covered before .. mRNA promising but complex and expensive .. however, I did find this section interesting..

“ Identifying the right targets
Creating a cancer vaccine requires taking samples of the patient’s tumour and healthy tissue, sequencing the DNA and RNA and comparing how these sequences vary between the cancerous and healthy cells to try to identify problem mutations that can be used as antigens or vaccine targets.

This is where the challenge begins: how do you identify the most relevant mutations that are really driving the cancer, a process that is notoriously easier said than done?

“The genomics in the tumour cell are chaotic,” says Prof Alan Melcher from the Institute of Cancer Research. “There’s stuff turning into protein that shouldn’t be turning into protein and there are other places where big chunks of DNA just either get dropped out or inserted or turned around. But at the moment, what we’re missing is how you predict the antigens that matter.””

Of course .. scancell has identified some and patented their use in treating cancer ..

Take care and fingers crossed for a good week !

Hi berm .. I found the thread after some looking and it does say ‘immune response’ .. but this was from the trial entry tests so it looks like one of the ‘counts’ didn’t meet the entry requirements.. heartbreaking news for the patient and a reminder of just how difficult this whole business can be!

Take care ..

Also worth mentioning .. all the patients who apply for the modi1 trial do not have a very good prognosis ..

Take care all ..

Vaccines act on the immune system .. so if you don’t have an effective one they won’t work ..

Can you imagine the effect on the trial results if you included patients you knew it wouldn’t work in ? This is very tough for patients who don’t fit the criteria but this is the result of knowledge and experience ..

Take care ..

… scancell does not have the technology in this arena .. Biontech among others, do !

Take care ..

TF- these are the patients that cell therapy targeting the modi1, 2 ….. epitopes could be the way forward ??

Take care ..

.. that wasn’t clear from me .. they check immune system ‘status’ not response … for Eligibility ..

Take care ..

Yes, there are immune response criteria on the trial entry requirements ..

Take care ..

Jack? Really .. he was a disastrous poet lol .. (allegedly)

Take care ..

Cancer Research U.K. does include the scope study on its website with information about accessing the trial ..

https://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-trial-SCIB1-pembrolizumab-advanced-melanoma#undefined

Take care ..

And an update from the SCOPE Scib1 trial with early efficacy date .. !

Take care ..

Would all three cohort 2 patients have had their first scans by this date !?

Take care ..

Morning Stan ? Is that a duplicate account? 5th post .. there was a Dstanley posted here but I’m sure he posted more than that?

Let me add a happy clappy comment .. IF there was some sort of buy out .. it could include cash and shares !?

Wherever scancells platforms go .. I’d like to be following ! Lol ..

Take care all ..

Still only 359 views !! Amazing really .. here it is again in case anyone passing through missed it ..

https://youtu.be/oGBn9pStUYs

Take care all !

Now on 226 views .. slowly creeping .. still very much under the radar !

Take care all ..

Finally managed to watch the full video..

It’s a great watch .. very ‘real’ from RG and blimey does he look happy !

.. it’s been available now for hours .. 148 views!

Still very small numbers of shareholders bothering to ‘keep a close eye’ !

Many thanks Marcus ! (And RG and Charles!)

Take care all !

I too look forward to seeing the full interview. Thanks Marcus!

We all knew Moditope was a serendipitous discovery, looks like the seeds of immunobody were too !

Take care all ..

Thanks for sharing that Marcus!

Nice to hear RG is still flying the flag !

Was interesting how careful he was when talking about the cohort 2 modi1 patients !

Thanks again.

Take care ..

Modi1 Clinical trials gov page last updated on Nov 21st .. so I’m keeping one eye on an update of that too with possibly more centres opening?

Take care ..

Modi1 recruiting up to 144 participants .. so should get some more data fairly soon ..

Take care ..