Member Info for Vander

We are waiting for lab results of nuvec delivering a c19 plasmid in rats- it takes 8 weeks for a top line result? At the same time the nuvec formulation is being repeatedly refined and so results are only ever provisional and dependent on the next iteration- a true sign of progress will be a commercial licensing agreement- it will needs a lot more funding to truly develop this

Remember fowler wants to get an MBE out of this- just remember who his funding his good work/charity - we need to be acknowledged also

The true vote of confidence and belief in the company share price can no better be expressed by their chairman
No one is better placed to make an informed decision regarding WSG share purchase. Let’s see what he decides- it’s verifiable and far more concrete than ephemeral daily opinion of ‘knowledgeable’ punters on here

There are three oligonucleotide-based therapies (Spinraza, Exondys 51, Vyondys 53), three cell therapies (Kymriah, Yescarta, Tescartus), and two in vivo gene therapies (Luxturna and Zolgensma), with more to follow
Main delivery vehicle are viral based, or lipid or polymers
There is room for improvement however- lots of research needed

https://www.nature.com/articles/s41467-020-19505-2

Baldry has not bought a single share- is that right woody?

Canacord waited for the SP to rise post tema, before bolting (like lightning) for the door- embarrassingly Fowler’s apologists here dismissed the warning over the following year, until realising that Wsg was still non profit making

Fowler’s gamble is to secure contracts on low margin and wait for future expansion- SHs will pay for the set up and have to bide their time at a financial loss

Also it is noticeable that sir tony baldry, our esteemed chairman, has not bought a single penny of shares- it tells you all you need to know- that guy takes a punt on almost anything!

Results due in q3 for the c19 dna plasmid delivered by the optimised version of nuvec
In the interim here is the nature report of inovio’s preclinical work from 2020- also a dna based vaccine which nuvec will inevitably be compared against- however there are concerns re the electroporation device, delaying USA trials

https://www.nature.com/articles/s41467-020-16505-0

The delay relates to discoordination between two of our contractors. It’s unavoidable as no development is done in house except possibly by the new full time government funded post doc
The optimisation of the nuvec formulation, as stated before was undertaken by nanomerics

Evotec are a CRO who have been contracted /paid to do the work requested
The optimisation of nuvec was led by nanomerics and that’s why the results have been delayed

Fowler expects to repeat the Freetown model in 5 airports in DRC- in the past his wider appreciation of the local political, geographical, and social context has tripped him up- also zero risk analysis based on complacency and incompetence- he is good on metal fences but would not realise that it is sited next to a volcano until someone sends the photos- this could be great-it could also be an unmitigated disaster with fowler leading the locomotive off the cliff

Thanks for sharing your knowledge

Challenges in the set up period- missed out ‘up’

Can anyone pass on the knowledge of the euro-ops team (size, experience etc). What infrastructure and systems already exist in DRC and what challenges will need to be met in the set period. Are the key contract parameters established- how will it be funded etc etc

Apologies if this has already been discussed on here- but I have missed it

WSG are making huge steps forward in guarding central london monuments.

Buckingham palace and British museum next- fowler should develop a tourist bus and river boat tours

Barrell also p/t FD
The young blood is Stuart and Joanna

Aiming- what are the fund manager’s pre-specified criteria for the hsbc uk special situation fund that you mention?

I thought the market cap and liquidity requirements were far higher?

On sky TV

Fowler has been watching this closely

https://www.google.co.uk/amp/s/amp.theguardian.com/world/2021/jun/19/iran-presidential-election-result-raisi-hemmati

It’s great you are back in - you are just the sort of person fowler loves - he blames you for SP destruction and yet relies on you for funding and ramping

Covid has killed off 5% of the DRC parliament and Ebola recurred in feb 21.

https://www.nytimes.com/2021/06/01/world/africa/covid-congo-parliament.html

https://www.telegraph.co.uk/global-health/science-and-disease/ebola-in-west-africa/