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:-)
yeah, if there was only something that could be done about that safety profile. no one believes it, it's way to good, I mean, if it was true it would be 200 exc china just round the corner. wiser heads than mine see the flaw, and adjust SP accordingly, I mean when have they ever been wrong.
Im just going to live the dream, and pretend the numbers point to something quite cool ahead for patients and investors. im happy.
Yeah, I didn't like to ask, in case I got called some nasty names again.
If a regime was keeping a patient alive, why would a doctor then stop dosing. Is that what a dosing holiday is ?
Thought if anything, any change would be for the regime to increase dosage or make it more frequent, not less due to good safety profile.
PL that would be awesome (patient image data at AGM).
Thanks
So, excuse my ignorance, p1b is to compare exiting treatment and see if 6K is better in controlled fashion. Both sets are being treated.
If 6K is shown to be better during trial are all patients moved? Maybe wishful thinking.
For 1a someone said patients would not be moved cos data is being collected and it would be dirty. That’s kinda harsh. I would have hoped docs could move patients to a better regime. I’m sure many of us would want them and their families rather than a nice graph.
I think there will be lots of good news. If you don’t have shares, go buy some. Could really fly in next 1-3 years IMHO.
Who said in 2020
"I look forward to updating the market on progress over the coming months."
good news flow, is not the same as “I anticipate meaningful revenue soon”.
I hope they come quickly, maybe a deal is in the pipe, but “significant news flow across the group” doesn’t give us any other information above that we all ready how. But love the optimism.
I read it as “don’t listen to (o) on the internet”.
Would aC1 patient being dosed higher “dirty the data”
You would need to include the data to start with, it could be kept separate. The C1 data has been collected. Seems macabre you keep them on that dosage just to see what happens or to keep a graph clean.
Also is PK data for a subsequent dosage affected by earlier dosage?
If it is, doe upping the dose provide useful data.
Not progressing… what of illness has progressed but has been slowed? Should those individuals get higher dosage.
Trial permissions, anyone know what praxis is?
Wait till the yanks wake up
Shoot I had pages more. I was cut off in full flow, which for someone my age is no joke.
I dance almost as well as I type.
Hi Mr Ripley,
Hope you had a nice day too.
Thanks for the feedback. Scatting ? Is that like Scatman John ? https://youtu.be/Hy8kmNEo1i8
That would be awesome, as a man of literary incompetence, which I freely admit, I’d love to do that. I’m trying to figure out if it was meant to be an insult. Have to admit my typing is shocking, fair play. Bloody small screen on an iphone.
Not sure I created a thread ripping anyone ? Do you mean thread Dosage. Others pointed out my poorly phrased question is one many have. All I asked was that the Dutch Riders , would let someone answer rather than throwing insults. You had some difficulty with that and maybe I gave back with a little too much gusto which you didn’t deserve. My bad, sorry. Hard to change gear when Micky, Rowboat and Popsicle are around thro.
Thanks Timster, great link. Mountain Biking, took me a while to get, made me chuckle.
To quote you Mr R, you seem to think I am concerned about people being positive. Don’t think I have mentioned that anywhere.
I can understand you are very busy, so to help you, here is what happened. Just for politeness sake.
Micky, I bet you win the wet the biscuit competition. Only cos Nr Ripply pumps you hard, so I hope you share.
Mr ripely, try some motion lotion, you’re starting to chaff.
Maybe rebalancing my portfolio. Asked a few question, pigeons came in, using big boy words.no need for it.
If people here want new people to invest, expect them to ask questions. I’d been interested in the answers but it gets drowned out in all the oh what a t**t, must be trading, etc etc.
Why would anybody invest in something new based on the Dutch Riders response. It’s not helping. Throw insults, I enjoy it.
So for us numpties and those that don’t sit on LSE for hours …
If a therapeutic dose has been reached in tumors not normally treated with pure DOX, why doesn’t ph2 start on original target tumors at this dosage. Expensive to run trials I guess, plus numbers.
If ph1 looking for MTB continues can ph2 up the dosage or is it fixed at phase 2 start hence we wait for mtb. Mac bang for buck.
It’s hard to wait but in long run quicker to get treatment dose right and not rerun a ph2 on higher dose.
Dutch Riders, take a break for a while, please. Try going outside.
Thanks.
I don’t doubt the science, to be honest I’m
not qualified. If it works it will be amazing for people and awesome for investors.
The article from the pharma new site was awesome. Helped clarify difference between progression verses survival.
Al has written and said stuff in the past which has been untrue or misleading. Trying to understand AIM speak is something we should all help each other with, at least LTH. Institutions get an inside line. Throwing insults is an odd reaction to thst, maybe people need to lower risk and maybe get out more.
It’s a phase 1 trial. Lots of drugs goto trial, lots of drugs fail at different steps. Grateful to people who take time to explain those risks. SP reflects that.
FAP targeting treatments have been tested and failed before I think. I don’t have links. Doesn’t mean this one will. It’s a risk. Balance portfolio accordingly. Help other to so.
Moneysponge
Ignore the Dutch Riders (https://youtu.be/ndp_RSeZn-g NSFW) whose only answer to any question about why SP is where it’s at or how the drug works is to throw insults.
Like pigeons spending their days squawking at every piece of enquiry. Any attempt to find a risk balance it becomes trafalgar square. Of course they have no doubts, I assume all 100% invested in Avacta.
Thanks. That was useful. Probably post if the day!
Heart broken
Rd thanks
Popsicle and rowboat,
Just giving back. If you don’t like don’t start it.
And cheers to those that responded normally
Hmmm have been burned by double speak on Aim, deep verge anyone?
So some (2 or more) surviving or not progressing.
Not wanting to to crass, and failing, but is it normal to see conditions not progress, at least for a period.
Basically some patients still be here (amen to that), and that being mentioned in a release, is it news? Could that have happened without ava6000?
You just copied what i said