Member Info for travel_light

anyone have a link or info ?

S83 please feel free to put me in your green room. That will keep you happy

Every time Marik talks horse **** and makes up “information” IMHO, I’ll try to point it out. It stops the bull**** spreading to every other thread. You may of course feel my opinion is wrong and why Marika is right, after all it’s a BB.. Happy to discuss why that is, welcome an opportunity to learn. That keeps me happy

Win win.

Lots of love TL

talk about making a mountain out of a molehill.

The way you put it Marik is that without the "data" supplied FDA would not have moved forward. You then imply it has reduced the risk of investment.

Does FDA know about p1, yep. Was the enough data to make any conclusion other than the limited dose (90%) and a couple of cycles max, didn't have a significant or unexpected side effect so bad that they were unhappy.....nah.

Marik how much data do you think they need before making a conclusion, how much is significant. Why do you think more than one patient is included in the trial. How many data points do you think are needed to make any conclusion ? sk his Lordship why he ignores those basics (see below)

Marik et al, ava6k is full of promise, it could change peoples outcomes in a major way. This is gonna take sometime.

my only conclusion is you are trying to pump and dump.

Marik, no need to pump and dump, this thing is up and down like a *****s drawers. Of course if you got your timing wrong that would explain your desperation to make every little titbit of information mean way more than it does.

https://en.wikipedia.org/wiki/Phases_of_clinical_research

its a good point, less stuff, more often etc etc. I've always assumed that phase 1 is basically can we give this to humans in any meaningful amount without bad tings happening, and other phases work out the most optimal regime. If it looks like a miracle cure, I think there are ways of getting to new phases quickly (would bloody hope)

not an expert

Hullaballola, good to see that you enjoy Mariks made up information as much as the rest of us. I'm more for Nordic Noir detective stuff, but a quick read of Mariks posts always helps me feel rainbows and unicorns are really are out there.

FDA probably has no data re phase 1, the trial started after Marik "out of his arse" date. FDA moving forward didn't need a prerequisite that indication were ph1 was successful- That said if patient (who is likely very sick, my fingers are so crossed for them, best luck mate), and a huge adverse reaction, there may have been a pause. All we know is currently one patient being dosed. Result unknown.

Risk hasn't changed from before trial data, but it's one hell of a payout if it works. I think it's a buy, but not cause the FDA has seen anything about ph1.

Sorry to be Marvin, I think Marik enjoys the attention, so keeps posting any old *******s just so some one speaks to him.

Hopes are high.
ps Marik say high to his Lordship, ask him if FDA would have need ph1 data set, thinking for yourself is so important.

Point

Similar risk profile

Marik would appreciate if you could outline what top line data includes. What is the nominal value and what do you consider to be exceptional. Where is Avacta on that scale (para 4).

I think antibody usage came from a third party brochure, but not sure. Most of us kinda knew. I think the weakness of it wasn’t appreciated by many, not even his Lordship mentioned it. Avacta certainly didn’t, not sure when they first mentioned it, abs information from company should be better than from a BB. Finding a new antibody might be quick but I have yet to see guidance from
Avacta when the test might go back on sale. Appreciate if you could expand your thoughts on why a rough timeline for that eg q2,hasn’t been given, if as you say it’s basic science. What reason for withholding such info?

Para 5. Are you saying that IND from FDA could only be given if cohort 1 data was supplied. Could it have been submitted before this data was given and still had approval. Very interested in your (and his Lordships) view on this.

Pre-clinical data was in mouse model. Let’s hope human reacts the same. Fingers crossed.

Given many of us have been above 2,50 I hope that stated target is well and truly blasted through.

As always, love your posts, they are the cuddly puppy posts of the Avacta board.

Yours as always Marvin, paranoid Android

other side effects

https://reference.medscape.com/drug/velcade-bortezomib-342256

was wondering what side effects so turned to Mr Google. Found the following link.

https://somepomed.org/articulos/contents/mobipreview.htm?13/8/13451

Velcade could goto grade 5 if treatment continued.

must have a setting for the old meat flute, always plays a delightful tune.

top, thanks.

Mr R...you owe me a keyboard, this one had tea sprayed over it.

anyone know if a generic is being used with Precision for AVA3996, and if so which one or ones.

SD, be grateful for a summary EVERY day:)

Anybody else put money into point?

I did. Trying to figure out if it’s a all eggs in one basket or a multiple shots on goal.

Any clinical trial or paper work that needs repeating ? How long does that take in your opinion if needed?

Bella are you saying they can just replace the antibody with any off the shelf omnicon antibody, or you feel that the screening testing etc has already been complete. That would imply that process was kicked off some time ago which begs the question why tell investors about the issue so much later than when the problem known.

Maybe they test for better antibody for all variants which would be a cool SOP.

Marik, can we agree it’s doubtful anyone else could produce a new LFD, ready for next phase, faster, However long it takes.

Spot on Vegas, with I don’t rally give a **** about wild guess’. But I do really care about your thoughts Vegas. It’s really important that you approve what I write, cos I really really give a **** about what you think. I really do.

Not invested Vegas…..wish it was true, cos I could really get a nice average. Bargain to be had. Guess a few of us feel that way. Roll on Ava6k. Could really be awesome. LFD….anyone think it’s gonna change of lives in next 3 years ? Maybe, is someone big buys the rights(that would be so cool and not beyond bounds of possibility).

Deramp….do you agree with Marik then that adding a new antibody, getting approvals etc will be a walk in the park and money will start flowing within the next few weeks. Wow top. Good for you Vegas. I don’t mean to Deramp, just playing interference on the pump and dump lot. Something to do when I’ve finished looking down the back of a sofa for any spare cash to put into Avacta and I’m bored.

RD impression. I’m insulted. Nah, I’m much more sophisticated type of wit, a sharp and pithy as a grapefruit, as opposed to his blunt, course humour. Plus he’s a twat.

Best question in a long time.

I wish I knew.

I think many are wishing that Avacta would say why.

Can we guess ? The antibody used to attach the colour but, which then makes the t-line visible when same protein grabbed by Affimers (which sticks to t-line). Happy to be corrected if I got that wrong.

Maybe issue with getting colour but to stick to affimer?

Maybe it’s a size thing(cos there is a difference, maybe antibody slows the s protein down). But I’d put your money in number 4 at Chepstow before using my thought on why as investment advice.

Lol, look whose turned up as I was writing, Lord “it’s a two week job max”.

You don’t need to be an expert on biscuits to know that if a open 3 packets of rich tea and they each contain 30 biscuits, to make a guess that the forth packet is likely to be the same. A degree and 20 years experience in baked wheat based nutrition is not required(say hi to his Lordship, do you cut and paste what he sends or rewrite from scratch).

Marik you keep making statements that producing a new test is easy but every time anyone cast doubt on this you get defensive and claim they can’t possibly be right because it conflicts with your view.

can an antibody binding with a spike protein interfer with an affimer which would otherwise bind with that protein. What challenges do you think need to be overcome to get the new test out?

If it is this easy why are Abbot etc not licensing Affimers and making LFDs. I presume they too have experts? Seriously if it easy to make a test then why is licensing Affimers for LFD so bloody hard.

Give us a date, when do you think it will go back on sale. As an expert you use have some idea.

I’ll make a prediction. You will ignore every question above and again say “don’t listen to him, listen to me “ .