The latest Investing Matters Podcast episode featuring Jeremy Skillington, CEO of Poolbeg Pharma has just been released. Listen here.
anyone know if a generic is being used with Precision for AVA3996, and if so which one or ones.
SD, be grateful for a summary EVERY day:)
Anybody else put money into point?
I did. Trying to figure out if it’s a all eggs in one basket or a multiple shots on goal.
Any clinical trial or paper work that needs repeating ? How long does that take in your opinion if needed?
Bella are you saying they can just replace the antibody with any off the shelf omnicon antibody, or you feel that the screening testing etc has already been complete. That would imply that process was kicked off some time ago which begs the question why tell investors about the issue so much later than when the problem known.
Maybe they test for better antibody for all variants which would be a cool SOP.
Marik, can we agree it’s doubtful anyone else could produce a new LFD, ready for next phase, faster, However long it takes.
Spot on Vegas, with I don’t rally give a **** about wild guess’. But I do really care about your thoughts Vegas. It’s really important that you approve what I write, cos I really really give a **** about what you think. I really do.
Not invested Vegas…..wish it was true, cos I could really get a nice average. Bargain to be had. Guess a few of us feel that way. Roll on Ava6k. Could really be awesome. LFD….anyone think it’s gonna change of lives in next 3 years ? Maybe, is someone big buys the rights(that would be so cool and not beyond bounds of possibility).
Deramp….do you agree with Marik then that adding a new antibody, getting approvals etc will be a walk in the park and money will start flowing within the next few weeks. Wow top. Good for you Vegas. I don’t mean to Deramp, just playing interference on the pump and dump lot. Something to do when I’ve finished looking down the back of a sofa for any spare cash to put into Avacta and I’m bored.
RD impression. I’m insulted. Nah, I’m much more sophisticated type of wit, a sharp and pithy as a grapefruit, as opposed to his blunt, course humour. Plus he’s a twat.
Best question in a long time.
I wish I knew.
I think many are wishing that Avacta would say why.
Can we guess ? The antibody used to attach the colour but, which then makes the t-line visible when same protein grabbed by Affimers (which sticks to t-line). Happy to be corrected if I got that wrong.
Maybe issue with getting colour but to stick to affimer?
Maybe it’s a size thing(cos there is a difference, maybe antibody slows the s protein down). But I’d put your money in number 4 at Chepstow before using my thought on why as investment advice.
Lol, look whose turned up as I was writing, Lord “it’s a two week job max”.
You don’t need to be an expert on biscuits to know that if a open 3 packets of rich tea and they each contain 30 biscuits, to make a guess that the forth packet is likely to be the same. A degree and 20 years experience in baked wheat based nutrition is not required(say hi to his Lordship, do you cut and paste what he sends or rewrite from scratch).
Marik you keep making statements that producing a new test is easy but every time anyone cast doubt on this you get defensive and claim they can’t possibly be right because it conflicts with your view.
can an antibody binding with a spike protein interfer with an affimer which would otherwise bind with that protein. What challenges do you think need to be overcome to get the new test out?
If it is this easy why are Abbot etc not licensing Affimers and making LFDs. I presume they too have experts? Seriously if it easy to make a test then why is licensing Affimers for LFD so bloody hard.
Give us a date, when do you think it will go back on sale. As an expert you use have some idea.
I’ll make a prediction. You will ignore every question above and again say “don’t listen to him, listen to me “ .
antibodies are quite large molecules. Could a new antibody block the affimer from binding, does the structure of the spike protein change at binding of either the affimer or antibody, does that affect the other. Is the chemical environment eg pH etc the same for both to act optimally. Is one antibody less sensitive than another and does that make it a more robust if less specific choice(affimer job). Do all antibodies cost the same.
Are all suppliers equally as good. Will authorities want a whole new data set with the new test, or can it just be rolled out with a smile ? How fast to get those answers ?
I think we have agreed I am not an expert and I don't have a reasonable insight into what is involved other than it took a long time last time they did this:) TT for abingdon seemed to be a fairly long process or is my memory playing tricks on me?
loving the cheer leading thou Rar rar rar.
I think the tech is great and as you say could change the world.
Avacta spun out is 2006 to do just that.
soon....
Interesting. Early days, no peer review but nice find. Shows potential of Affimers even thou it’s a different molecule (I think).
What’s happened that FDA approval has suddenly become easy. It that new or has it always been that easy ?
Does anyone want to buy a “Roll on Mid-summer” t-shirt. I’ve got loads of unsold stock from last year (and the year before that). Three colour choices
Make a Guess Green
Anticipation Blue
Thank **** for Ava6K Teal
Tl(Non expert)
No I think we are making up random numbers and dates when we guess the LFD will go on sale.
Have to admit your random number technique is very impressive, but could you put a few together on some sort of timeline?
Ah the good old days.
To be honest it was Al that first said mid-summer.
If we only had someone who knows about these things who could produce a timeline to help poor Myles, sorry I mean Marik.
So you do just make numbers up. Glad we cleared that up.
Keep telling you I don’t propose to be an expert.
But with Mr Google help I find
If an existing mAb is available ( A ), pairs can be identified by screening a recombinant library in the presence of the mAb. Alternatively, a library-against-library method might allow rapid screening for antibody pairs ( B ).
Going to answer the questions you have been asked or try to deflect you are just making things up by asking me a question.
Lol not sure what needed clearing up? Nice deflection.
Marik how do you generate your numbers, do you pull the numbers from a hat or use a roulette wheel?
Hospitals are in a state of chaos. To be fair to bod there is probably little they could do to stop timelines slipping.
If we get news great but let’s not worry too much if there is a delay.
Not a scooby of an idea. Only base my case on how long it took last time to get paper work done. I already wrote that. I
So I can only surmise that you are asking again to deflect from my question and the fact that you just make numbers up to pump the share.
Keep pumping Myles, sorry I mean Marik.