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I have no idea. I don’t claim to know. Neither do I shout from the roof tops that it will be an easy fix
and that info is just a wild guess/rise tinted hope.
What I do know from previous experience is that paper work and approvals are slow. I have no knowledge that it will be ready before or after a certain date. I have a pure guess it will be a long time and happy to say it’s my guess.
3-6 weeks. If you are stating that it’s so you are making an investment case for yourself and others. So if it’s good data say so, but if it’s just random numbers that you think pretty it might be an idea to tell others who get wrapped up is your pseudo expert persona.
My guess is they are random numbers you think look pretty. Am I wrong ?
1,87 is nailed on, at least when the yanks turn up. But is it us ?
All we need is a few Amen and a good sausage thwacking and it’s 2020.
I think given the past a LFD with CE mark and HUA will be available in Europe for this summer.
No data other than the past performance.
so this should be read as "Affimer can't be used on their own but must be combined with existing technologies ?"
working with others eg when beads are coated to grab a protein (Bams?) is what I thought it meant. Affimers will replace antibodies was shouted. affimers and antibodies together is a better solution was rolled out in a recent RNS at a whisper.
not sure why anyone is defending BOD about this. It has handled like ****.
realistic expectations rather than ramping but maybe too much to ask.
the test will otherwise remain the same i.e., as Abingdon optimised all processes and elements for mass manufacture previously (completed mid-December 2021), this should be an expedited process
so it swaps out a massive bit that contributes to sensitivity, and we assume the antibody doesn't block the affimer binding site.
2 weeks retesting if it works.......
how long will paper work take. I assume you can't just swap out bit and use same CE mark.
great cheer leading, even if not a lot if use.
if it was hollywood the star quaterback would have arrived by Uber and just be running onto the pitch with seconds to go, but real life especially for Avacta kinda says not.
lets remember this date and I'll bump 10 quid to the local donkey home if this time next month there is a CE marked replacement ready.
from another thread the cautious optimist wrote
**"Likewise, perhaps having the Affimer relatively “unencumbered” and mobile in the sample fluid gives it maximum chance to locate and latch onto the spikes."**
search, grab, and immobilise on T-line job of the affimer, and sentence above is a clear benefit of an affimer. No one else said it but helped me out of my funk. Good point CO.
Having a molecule that can show colour and can grab same protein isn't so tough, it doesn't need to be specific. If the antibody GRABS a protein from some other virus, so what, it will flow past T-line and show up at C. This problem is caused by the antibody being pretty specific, but too sensitive to mutations.
Avacta should be using this as proof that affimers are better than antibody test. Being smaller, and a lot more targeted, mutation doesn't affect them so much. The affirmer doesn't care what the rest of protein looks like, it can change all it likes, the affimer still hits the binding site. The antibody is so affected by changes all over the protein which are a lot more. Of course if affimer binding site changes/blocked the affimer is buggered, but given that the site is essential for infection maybe thats a lot lower risk.
So a paper about why did this LGD fail ie a why antibodies LFDs are not good at coping with mutation would actually improve Avacata position. Go on the attack, show why affimers are better.
Shame the antibody chosen was so targeted, maybe a less specific antibody combined with highly specific affirmer is perfect mix. Maybe why Deepverge mix with aptemers.
End of day it's an expensive lesson. Also my knowledge on this level of molecular engineering is old and rudimentary, so might be way off base.
The niggle I have is why the switch to antibody. It’s carry’s the blob of colour, attaches to the protein from the virus which an affimer attaches to (which then sticks to T line).
But it also needs to be grabbed at C line if no covid s protein present.
Thought affimer could be used to carry colour particle and have a different variable bit to stick to C line. Seems like antibody needed.
Hopefully it’s not because of production issues with Affimers but maybe related to attaching colour bits?
Would really like to know why antibody is better than affimer for this purpose. I fully expect Al not to answer this question until forced to.
In it for TX. I’d vote that DX is spun off as I don’t think current management is capable is realizing value from Affimers. Last 2 years kinda provides a good appraisal of this.
Hanging on with fingertips
Affimer binds to S protien and captures it
Antibody binds to a colour particle
Antibody plus colour particle binds to what…. The affimer or to the virus via non specific binding site
The whole lot goes up the strip. At T line an affimer specfic protein captures the affimer attach to virus attached to antibody attached to colour particle. Hence t line goes +ve
Yeah not COVID affimer isn’t attached to virus/colour. Stops at t line but no colour
Rest of colour particles captured at c line
So why is a ohmygod variant antibody needed? Any antibody attaching to common protein would do.
how did you think it got there Marik ? Explain why it needs an antibody to carry it. Why doesn't the protein get carried in the flow, or does it, and the antibody is for something else. Please supply the link where Avacta explain all of this, clearly.
"how did you think it got there".....lol. Call his Lordship, he might be able to help you cobble an answer together.
despite analysts not having any LFT sales in their forecasts-------
the decline was due to the realisation that warm feelings and waffle from the CEO don't replace transparent communications with investors. Trust has collapsed and Al feeling good about something is taken as being " we still don't know what we are doing and are keeping our fingers crossed".
the only news that will move this share price is new CEO.
Public contracts won’t involve M19. They are distributors to retail for LFD, or direct to consumer.
Also look at Norway procurement doc. 7,5 million in revenue in last 18 months required to even bid. M19 doesn’t even get into the starting gate even if they wanted to supply to public organizations.
It will need to be Avacta or another distributor.
Hopefully Avacta bidding on these sorts of opportunities, but my fingers are crossed for ava6k.
Given that an RNS is needed for any significant change eg projected revenue, I guess either the BOD is ignoring the rule to keep share holders informed, or they don’t know, or there is no change. A change is also valid for when statements are known to no longer be valid eg we expect xyz soon. Soon has come and gone and can’t be a moving target to meet need to communicate.
Say 1 million had been sold, or 10 million etc it would be nice to know.
Great tech, pity the comms is so lousy.
Ava6000 is worth staying for. LFD is a roll of the dice, given ability to execute and the lack of forward looking information. SP reflects that. If RK were here he’d be shouting Amen and topping up.
I sold my bike on eBay. Not going to tell ya how much for or make any statement to how many I will
try to sell in the future. I would appreciate recognition as major player in Transport Solutions.
Mr R, without mentioning the LFD, business is great, nice little pharma early doors research shop. A little behind the plan, but world events are what they are. My words were clumsy , more meant about calls for a statement about UK gov etc which are not really business info. Silence in that respect is probably better, ****ging them off publicly serves little purpose. But other news around the LFD business would be welcome as basically if Avacta can't make a success of covid DX 2020-22 what chance do they have of real money 23-25 from DX (cos that part of the business is very pear shaped IMHO). Hope is for partners to step in, but the business, release value now. LFD could be just a "see Affimers work" project, but then things got heated and carried away. Is the strategy for Avacta to stop owning the whole LFD for new tests, and just sell the affirmer IPR, or will they research/make tests for others things ? Who know.....(Al does).
CJ...CEO can communicate with shareholder regardless of RNS needed or not. TT for Abingdon, maybe it's interesting to shareholders or should that not be a consideration ? Balance in all things, but "promise" is made, why would you keep good news quite even if late ?
HM..... I think its "A". Scientist with limited experience in the real world, can't believe that "build it and they will come" doesn't work out. Hard lesson learnt maybe, I hold my hand up I am also shocked by the environment in which they are operating. I was talking to an importer this week, who was working with LFDs/PPE for Scandinavian market. He was opinion, its the wild west with big boys pulling strings behind left right and center to protect their market (eg research funding if you buy product xyz). But I am no CEO, and neither to I claim to be.
That he struggles with some aspects of a CEO is a concern. Great Chief Scientist maybe, but can anyway honestly say that the way the process has been managed is a template for others to follow.
It's easy to sit on the sidelines and shout "oj ref, send him off". Maybe he is playing a blinder, but with little in the way of information, and what is available often hope/rose tinted opinion, the investment case for me has move to AVA6K. If LFD brings in some dosh, great. I think given there is significant value to be had from Affimers and DX. Even if the ball has yet to be dropped the ref is calling it a knock on following a crunching tackle from the opposition.
happy new year All by the way.
yes he secured funding....good timing well done.
Expectations were raised, are you saying that we should not expect the CEO to meet them, and that's its ok cos it was someones else's money ? His job is more than just making power points to get money, he also has to deliver on the promises made. Or does he not have to do that ?
If Avacta fails to meet expectations re DX, where should the blame lie ? If someone else had been in charge would the result be different. Why spend time and effort (money) for little result. Should Avacta stay in DX, if they cant make money from that market ? Covid is one thing, can money be made from other DX projects, or is the management of that side of the business lacking the ability to make money ?
re comment about governments... agree that he is rock hard place time, but that doesn't justify the radio silence we have had since things went pear shaped re the business generally.
he could always supply and opinion without an RNS....communication. Silence is also communication, but hard to interpret. Could mean almost anything.....this BB proves it. If you want others to know what you STILL think and believe, is it so hard to say it?
At the mo, it's easy to read as " don't care about LFD, M19s problem, not enough money to talk about, spinning the wheels cos we don't know what to do"
of course the silence could mean multi billion contract is about to be signed, shhhh there is an NDA, 200 ex China.
the truth is somewhere in between, but a CEO should be at least part of the cheer leading team if he wants investors.....ahhh forgot, he's got his 40 million so bugger it. Works right up to the point where enough votes put pressure on ya.
as a side question, what % of votes do the BOD control ?
Vegas my guess is he has a bunch of IDs registered and he runs a script that logs in with each ID and ticks his post. Not sure what effect he thinks it has, maybe others think “oh he is so wise to get so
Many recs”. But then he starts the thwacking when met with counter opinion and the spell is broken.
quote...."INFINITELY more difficult to secure".
I heard some ramping in the past 12 months, and some large number, but Infinity....WOW. :-)
Maybe if you don't know how to design a home use test and procedure. Otherwise it's "more difficult" to secure but medical device industry has been doing it for years. Great news, but maybe a bit of perspective?
good to see many looking outside the UK for markets and opportunity, instead of looking at Boris and the clown car.