Member Info for TorquayFan

Ipad - I love an optimist. Yes that'd be nice.

Here it comes . . . . . BUT, it's an Audit delay apparently so when they've completed, I think the AR will be trundled out and the marvelous deals you mention, will be RNS'd later, as and when. ATB

Violin - the answer to your question 08.49 is 'nothing at all'. Paul B 08.24 was making a different point.

I'm hoping we get an RNS and maybe the Annual Report tomorrow. C11 yes good to look back at what we can expect, (sometime or other LOL).

Bojo 09.07. Not sure what that's about but I AM confident that BoD Scancell and BDO will sort this out in a fully professional manner.

Just MO but if we don't get the Annual Report tomorrow there'll be some further explanation. Enjoy your day all.

Re. RNS - so will I Chester.

And that's the 2nd 'too' with one 'o'. ATB and GN.

Chester yes of course I know of BDO. I was a Chartered Accountant for 40 years and an MD for 20. But don't ask me about the science LOL !

It's not a question of "they could not raise enough paid hours" - if a problem arises with 'one in the know' in the Audit team it's not that simple.

Criticisms of BDO dumping some Clients are irrelevant - this is not the case here.

I think you are talking about 'post Balance Sheet events' but live in hopes for this - "they will include everything up to the date of the release". Everything? Like 'real time' ?

And "It should always be a report of, where we are at that point in time, plus a forward looking statement to lay out what the next twelve months should achieve". No - we'll get the science through data on RNS and the commercials through RNS. And 'telling us what we are going to achieve' - dream on.

Sorry to be little frank but really - RNS Monday 7am or Tuesday 7am IMHO.

Ray 09.23 spot on . . .

C11 09.30 - but no heads in the sand around here . . .

Violin 09.40 - you interpret "due by the 31st October" as being 'before' but it can also be 'by the end of'. To frame BDO as 'incompetent' is wacky - you don't know what their problem is. IMO expect an RNS on the 30th or 31st.

Dracula 12.09 - first good sense posted is "What's the problem". Or , 'why the tyre kicking?' put another way.

Chester - why are you "amazed'. You don't know what the problem at BDO is. I agree with "Always look on the Bright Side" BUT this, "The delay from the 13th November until now has allowed time for more up-to-date data gathering and hopefully emails back and forth on any potential deals", is IMO fanciful. The 'Annual Report' is the accounts and comments thereon with a review of progress generally not an update on latest commercial discussions.

Violin 13.01 - Para 1 - I'm sure your Guy Diggle can take a balanced view. A bit of tyre kicking again here V - "implications for Scancell and the directors". Balderdash. And "I would expect an outfit like Redmile / Vulps would have included a clause to protect their investment should such an event arise". Balderdash.

Sweet Lord save me from this stuff. Patience !

C11 well be disappointed IF that happens but it hasn't yet.

cw 18.16 - yes i too expected notice of the annual results last friday but it should be monday or tuesday. whatever the problem, bdo will be sorting this so it's 'wait on' !

we don't know what the bdo problem is but talk of 'sacking' them is premature.

violin nice find but the criticism of bdo in that report seems to be related to the dropping of dodgy clients - "over the last year . . (bdo). . have already exited a number of high profile audit gigs in the uk. notably, august 2022 saw reports emerge that bdo was set to quit its role as auditor of beleaguered lifestyle management firm *****essentially, while october saw the auditor begin to withdraw from its role at everton football club – as the club struggled to stay afloat in the english premier league."

that part of bdo strategy seems ok to me !

Violin - your 17.42. Re. attending ESMO, remember Scancell's team are very busy and having been at WVC I guess they chose not to 'do' ESMO. Forget the 'signed off idea' - IMO we would be told as and when and these matters are not delayed to announce at a Conference.

Nice one WTP :-

"Key duties and responsibilities:-

Receive and process clinical trial samples including human serum, blood and tumour samples.

Perform immunology-based assays on clinical trial samples ensuring these are aligned with the clinical trial protocol requirements. The assays will include, but are not limited to, T cell culture, ELISpot assays, flow cytometry.

Maintain accurate records and present results in a report format.

Ability to work overtime to accommodate occasional late arrival of clinical trial samples.

Accurate recording of receipt, tracking and storage of clinical trial samples.

Perform stock checks of consumables, media, solutions and buffers.

Receive deliveries and unpack stock into laboratories.

Role requirements:-

MSc or BSc with practical experience of working in a cell biology laboratory.

Capable of working independently as well as the flexibility to work effectively within a team.

Experience of growing and maintaining cell lines and preparing reagents when required.

Excellent organisational and planning skills.

Good communication skills.

Proficient knowledge of MS word, Excel, PowerPoint, and Outlook

Ability to travel within the UK if required."

We have 'nearly 60' Employees and I was pleased to see this : "Applications from recruitment agencies will not be accepted". Good they are looking after the overheads !!!

Nice ad. Good job. Come on Scancell !!

Thanks ICB.

Marcus posted this ProActive on the other side :-

https://www.youtube.com/watch?v=vwC-brP5Ceg&ab_channel=ProactiveInvestors

Just one month ago . . .

Just one month ago.

I agree DeAar - the BB is missing regular stuff from Crumbs, Bermuda, Ray, WF etc. that used to keep us on track. Now this wallop takes over at every blink. I just wish the very long missing Inanaco was here too. If only.

Maybe the BB has outlived it's usefulness - it's all about data and deals now. Hopefully. Just watch the tone change the moment news arrives . . . .

As for Scancell - always a good time to buy ! AIMHO of course . .

Ruck 13.10 and Violin - the discussion with Analysts and Investors was to be based on the Annual Report which is why CEO is doing it with FD. I can hardly believe my eyes at this rather desperate stuff.

Violin reading between the lines of your 14.03 (not much) is a little sad. Exit price 50p? Your chance IMHO will surely come. Myself I'll be waiting for much more. I hope all is well with you and yours. ATB

WTP - your shirt is on this ? Me too LOL. Broadly moving towards a Nasdaq listing would be, enhancing, probably.

Thanks Chester for lighting the touch paper (wink).

Chester - whilst we would hope the Annual Results will be released by the 31st, with reference to your comments :-

. . . "should mean they now ensure resources have been mustered" - not necessarily, we just don't know the circumstances at BDO that caused the delay.

. . . "Anything beyond that date shows that BDO are in complete disarray". Um - no it doesn't. How can you say that when again, we just don't know the circumstances that caused the delay.

. . . "We can also be fairly certain etc.". Can we ? Why ?

Discuss what you want of course but I don't see the point of stirring up impatience over purely admin matters - IMO wait and see is the best counsel.

Also of interest will be the rearranged Q & A sessions for Analysts and Investors. We will be advised of these matters when possible I'm sure.

Yes I know that Drac - https://youtu.be/xtTdQm57_MU?t=11 . . . . but everybody IS someone's child are they not?

A poor analogy - time will tell Dear Chap !

Over there, (SFI thread) - Inanaco 158 . . . (Caps added)

"Indeed .......... this statement has just been proved by Scib1 ................

"""" T-lymohocyte-associated protein 4 (CTLA-4) blockade results in the enhancement of the activity of high avidity CD8 T cells """""

High avidity CTLs are effective in antitumor immunity as they require lower antigen concentration for activation and effector cell function.40 41 However,

they are more prone to functional impairment in the immunosuppressive tumor microenvironment.42 43 CD8 responses are particularly sensitive to inhibitory signals in the tumor environment and antibodies targeting inhibitory receptors on T cells have been used successfully to reduce this inhibition and improve T cell effector function leading to enhanced efficacy of antitumor therapy.44 Our works and that of others have shown that Programmed cell death protein 1 (PD-1) and Cytotoxic T-lymohocyte-associated protein 4 (CTLA-4) blockade results in the enhancement of the activity of high avidity CD8 T cells induced by vaccination in a preclinical model"

Inan thanks again - just trying to get some more comment on this, published by BMJ 19th October Https://jitc.bmj.com/content/11/10/e006966.info

Re. Ray Pointer here 22/10 15.41 - """This is truly left-field news since it potentially makes Modi2 more powerful."""

Over there, (SFI thread) - Inanaco 156 . . . (Caps added)

"Lot more research to do before Scancell include that into a vaccine. The two peptides for CD8 (Cyk8 117-125Hcit and Aldo 209-217Hcit) identified showed high binding affinity to HLA-A2, a property that is important for the

immunogenicity of peptide epitopes.

Modi2 is NOT targeting a CD8. Modi2 Cyk8 371-388Hcit. Aldo74-93Hcit "

Thanks to Inan . . . .

Dracula looking for suckers again ? Sorry, I know what you allude to but this is what I found on a search https://www.google.com/search?client=firefox-b-d&q=nobody%27s+child#ip=1

CW move on.

Well done WTP and thanks Bermuda, and Ray "it potentially makes Modi2 more powerful." I've posted same 'over there' to hopefully get more comments. ATB

Thanks WTP and Taverham