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Violin 14.36 - here's Inan's take you referred to :

"The Fc to Fc modification has already been tested on mice and humans .... with the covid vaccine. There are not new epitopes as such but a broader spectrum of the same Antigen for HLA - for instance SCIB2 has 16 variants of the antigen NY-ESO-1 but none have been tested with Pd-1 and CTl-4 even though SCIB1 has".

Maybe because the Iscib1 t cells are more potent, testing in mice with both checkpoints might be appropriate, if you're the MHRA .... but they allowed it for scib1 ... without mouse testing. Red Tape ?" (puncs added).

Inan adds some links in 7206 and 7207. Thanks Inan and Violin etc.

Ray - I listened back and the comment of Prof. Lindy is at 8 minutes 45 seconds. I guess it didn't mean what I thought it did . . . .

Inan's 7197 yesterday comments further on yours and interestingly on SCIB1/iSCIB1+ - you may have seen it.

Congrats on the 5-0 !

Thanks Ray. I remember Prof. Lindy saying that there was a 90% chance of the next stage succeeding (E & O E) - but I'll listen in again tomorrow. Whatever, come on Burnley !

Hi Violin - thanks for that. Its not all good, (but it is). The feeling of many Posters, much more in the know than I am, has often been expressed, that all the data must be in before Pharma will move. They are probably right, but IMO, nevertheless, a move at an earlier stage is not too far a stretch.

If we have a 90% probability that SCOPE is just gonna get better, well that's great progress and bound to catch the eyes.

It's been a hard week for us LTH with the surprise 'raise' - just the day before we heard the BoD and NO hint of course. By the same token, some other stuff may be going on.

BUT, I was partly motivated by the thought we may be in for a quiet period, although Scancell should be doing some PR in the next month or two. But if it's a long wait again, it's chins up for us, because, she'll be coming around the mountain, for sure (IMO).

Maybe I'm trying to tell myself to chill a bit. That's all. HAGW

I noticed in WF's 11.19 yesterday, "could this be the last fundraise event Scancell do in their current form?" - yes indeed and that locked into something I'd been pondering myself.

If the next updates on the SCOPE trial are good or even improve on the 85% a little, I think that could nudge some early interest. It's logical to expect approaches when all the data is in and completely tied up, but there's also the possibility that a Pharma, particularly one not lost in the mRNA tunnel with projects of it's own, could make an early move. The timetabling discussed by BoD at the AGM is based on a logical progression but don't rule out a 'short circuit' where someone with a cupboard that's empty on the 'immunology' front, might do make a pre-emptive move of some sort, (but that will not come cheap).

The prospects of iSCIB1+ and Modi1/2 are really exciting too.

Meantime as HBD Mandeep works her own 'buzz', we might expect something from the amazing antibody platforms Glycans/Avidimab before too long. It was brilliant to hear that Genmab are progressing and looking at another target.

Bermuda thanks for pointing out earlier, the nature of the Texas outfit.

And Douve, nice reply to mine !

I used to post 'she'll be coming round the mountain WHEN she comes' and still think that - we won't see it coming until the moment. But it's quite possible we might be surprised inside the logical timescales.

Meantime, IMO the success of the Scancell project looks increasingly assured

Now that Scancell have confirmed the SCOPE trial shows an improvement in the standard of care in melanoma stage 4 from 50% to 85% and the data hurtles on, with every indication of getting better, and the BoD have quietly raised £12 million (?), of course, we have to be unhappy. Obviously.

I too prefer 17p to 11p but lets not get carried away.

Yesterday I was worried myself that the raise was too small but I feel much better about it today. WF good post.

Violin you have lost the 'Chief Moaner' title to Douve.

No point in tearing it apart - relax. All the pieces seem to be in place now. Just time needed - (as ever). Keep smiling Guys.

Interestingly the posts 'over there' seem generally sanguine about the news.

WTP - re. 22.47 : with respect I'm glad it's the BoD in charge and not your goodself. I'm surprised at the RNS but mainly because the placing is just £8 million. Ride with the blows (again) - there's enough science here. It'll come good. AIMHO

Good post Cleaner - just one thing - seems like a 'lifetime' rather than a 'lifestyle' of long term patience'. Never mind - Scancell are getting there.

Scouse - I agree with that - maybe that'll come later.

Crikey Burble - never 'eard of it ! But well done !

Kash I agree. Heaven forbid that a new pandemic should start but Texas might be interested then - (if not Scancell). However, none of us want to wish THAT on ourselves. Evenso - you never know what else might transpire - but IMO its a 'don't hold your breath' matter.

Had a good listen to that and many thanks Botski (again) and to Mia for the clean up.

Bermuda - re. "then went on to say that they're considering opening a new cohort but I couldn't hear the cancer type - it was ............carcinoma." I listened several times at volume but couldn't make it out the word prior to carcinoma. It's seconds after 26.45 on my screen. Prof. Lindy will surely tell you if you ask.

And thanks Bermuda for the usual clear explanations and insights in your posts.

Two things I noticed : 1. In the case of SCIB2 (or 3) I think it was inferred that they might be amenable to an early stage deal and 2. an interesting aside from J-M C following a brief chat about Moderna and BioNTech vax competing with SCIBs, "I'm not too scared of the competition". (Bermuda's 21.54 point 1. elucidates some more).

A good belated AGM and Prof. Lindy says that the delayed Analysts/Investor's day is postponed and she mentioned a month or two as the timescale.

Good meeting - well done Team Scancell. My confidence is still sky high but I'm getting older! GLA

Kash yes there was a question about Texas Biomed in the Q & A.

You might like to look at Bermudas post 27.11 at 19.17 - "All the same research which has evolved as additional analysis and testing has been carried out by Scancell or by Texas Biomedical at the request of Scancell."

The answer at the Q & A was in line with that. From which we may conclude that Texas BioMed have no separate research or progress underway atm?

However, it's a positive point that a large BioTech has insights to Immunobody's science - who knows what may transpire? Maybe not much but you never know!

Burble - Botski is going and has said he'll record it. Thanks to him.

Another RNS update today ? That would be good !

GF yes good question, 'whole sale' very unlikely IMO but maybe part-sale(s) possible with a clutch of 'multiple licensing deals' too. I'm guessing that the answer will be apparent as Prof. Lindy presents, but otherwise, the question should be asked as you say. An interesting day in prospect!!

And Botski thanks in advance . . .

Yes a disappointing rise particularly for those who remember the excitement of 'Moditope day' aeons ago. As data gathers this will re-rate. And IMO that's before too long . . . .

Ray - I remember Blacklaw, Angus, Elder, Miller, Adamson, McIlroy, Connelly, and RP. I saw them during Div1 Champions season 2.1.1960 winning 5-2 at Upton Park. Long time ago. Those were the days eh?

(Sorry for off-topic).

Paul - don't agree. Time will tell . . . . . .

HH 11.59 - "Let's face it - only people with scientific knowledge will be able to process and realise the content of the RNS. For the average retail investor this goes way beyond their fill of expertise - and mine".

Spot on - ATB