Member Info for TorquayFan

RW and C7, I do agree that the appointments of Dr Samantha Paston and Dr Adrian Parry were positive factors - for me, that's a definite acknowledgement that Scancell has the science. You ask, is there something developing? Of course, the science is !

Can we take more from it than that ? Maybe, maybe not. Scancell have had an array of very impressive science for some time - whether that leads to commerciials or non-dilutive funds arriving, as yet we have to see. But so far little progress on that front.

Of course the Appointees were attracted by Scancell's science - but is it likely that during Recruitment, they could have been let into the picture of other hopes of a commercial nature? Myself, I doubt it.

RW - sorry to revert, but can you please explain the nature of the ''thorough research and networking'' process you brought to my attention recently?

Yes I agree.

C7 posts 35438. In the last few years say that's 20K SO 'most of' that, would be circa 10K posts. Two posters are alleged to have reported C7 more than 10K times ? With respect, I think that was worth questioning politely as I did Wed 23.09. If I see an obvious inaccuracy it's reasonable to point it out.

You weighed in with your comments Thur 11.19 - ''C7 'knows' what got reported because he had it from the horse's mouth, a consequence of thorough research and networking''.

So a) you confer truth on the allegation of 2 x 10,000 reportings of C7's posts, quoting the 'horse's mouth' - forgive me do you imply then that 'Admin' is the source of that ? I doubt your statement 100% because, such a level of reporting is not credible at all and anyway, I trust in Admin's discretion . . . .

and b) you moot ''a consequence of thorough research and networking''. That's interesting - I think you should apologise or explain to the BB, quite HOW that would be done. Awaiting that with interest.

Hysterical is indeed a fair description of your Thu 11.49.

You really don't help anyone with your comments. Really !

Thanks. OK. So the very act of electroporation itself, won't affect a body in which Keytruda is already active. Looking back I see you have already answered that. Sorry for the silly.

Of course, no RNS today - Good Friday i'nit. Tuesday then.

Wish you all a nice Easter weekend - I was hoping to watch Chippenham Town v The Champs as it's near my UK base but in the end not possible.

Wobbling around in my non-scientific mind is this. Trigrid2 is approved for delivery of vaccines and CI is approved for treatments. But could the FDA's reservation be, Trigrid2 delivery of vaccine when CI treatment is already in place or about to be in place ? (I did say it's an idea wobbling around).

Would that be a Catch22 situation ?

We should be told . . . (I did say it's an idea wobbling around). Good RNS coming 2M LOL

Just before I knock off for the evening - re ADVFN. Regrettably, a number of LSE posters have moved, for whatever reason, so I now read and post just a little on both BB's.. As it happens, there is stuff worth sharing - it's not a battle. As for sycophancy - in 71 years I've never been accused of that LOL

I try to be polite but will argue a point if I need to. Even with you RW ! BFN

Calm down and please don't be insulting.

Is it not very unlikely indeed that two posters have been reporting 'most of' C7's posts for the last few years ?
Or that Admin would have told him so ?

You post, ''C7 'knows' what got reported because he had it from the horse's mouth, a consequence of thorough research and networking'' - excellent.'' Perhaps you can explain that interesting process a little more ?

I wondered if C7 had posted in an odd moment and thought it might be helpful to point it out.

You really don't help anyone with this hysterical stuff.

Nom - the idea that Admin 'aggregate' posts before acting - IMO that would be very odd indeed.

C7 - ''I actually do know of two posters who have been reporting most of my posts for a few years now''. I seriously doubt anyone would bother C7 and how would you 'know' that ? 'Most' of 35,434 posts ? That would be one very busy reporter ! Admin are very discreet are they not ? Re. NEX - I'd guess it's just against their rules and that's it.

Chester - such delay at the FDA is very hard to understand and maybe BoD will explain more via CH at the coming ProActive meet ?

GLA

Good to see you posting here Knowlesi. I agree with you about Admin.

Bermuda's first comments in reply to Ivy :-

''Yet more evidence (if any were needed) that nobody yet fully understands why some patients respond to PD-1 and some don't. I understand that the NF-kB signalling pathway is connected with inflammation but that's about it. Interesting that out of 400 patients only 52 had been treated with anti-PD1 and 21 of those were responders. The findings that 67% of responders had alterations in genes associated with the NF-kB signalling pathway as opposed to 19% of non-responders actually translates to a difference of just 8 patients - so clearly very early days to be drawing any firm conclusions.''

Thanks to Bermuda and Ivy - more of the same elsewhere - interesting indeed. GLA

Thanks to Ivy for posting this interesting link - discussed here before by Inan and others.

''AACR 2019: Is your melanoma hot enough for immunotherapy?

Melanomas tend to be 'hot' or 'cold' - if they're hot, immunotherapy lights melanoma tumours like beacons for elimination by the immune system; but 40-50 percent of melanomas are cold, making them invisible to the immune system, and patients with cold tumours tend to show little benefit from immunotherapies.

The problem is that it's been impossible to distinguish a hot melanoma from a cold one - the solution has been to administer immunotherapy and hope for the best, often leading to wasted time and resources. Now a University of Colorado Cancer Center study presented at the American Association for Cancer Research (AACR) Annual Meeting 2019 identifies a possible way to predict which melanomas are hot and cold . . . . ''

https://ecancer.org/news/15754-aacr-2019--is-your-melanoma-hot-enough-for-immunotherapy.php

With respect - nothing 'low' - bar the level of enlightenment in your replies. So please explain what you mean by 'make' or 'commencing'. 4th ask. Then maybe, someone else will have a stab at answering your question, ''anyone still think they make the H1 SCIB1 Combo in time?''

You wanted Folks to guess - here's mine again, ''the wheels will roll H1 as we will have FDA approval by then''.

. . the DNA of tumours, scientists have discovered, in a breakthrough which could finally show how much disease is attributable to factors like air pollution or pesticides. Until now the roots of many cancers have proved elusive, with doctors unable to tease out the impact of a myriad of carcinogenic causes which people encounter everyday.

Even with lung cancer, it is not known just how much can be attributed to smoking and how much could be linked to other factors, such as living by a busy road, or inhaling pollutants at work. But now scientists at Cambridge University and King’s College London have shown that tumours hold information like a 'black box' pointing to the cause of disease. They exposed stem cells to dozens of known carcinogens and recorded how each alters its DNA code as cancer forms. It provides a ‘fingerprint’ or ‘mutational signature’ of the underlying cause and could even show which was the biggest culprit.

https://www.telegraph.co.uk/science/2019/04/15/cause-cancer-written-dna-tumours-scientists-find-creating-black/

''You now have access to the new London South East Beta Website''.

Just had a look at that and it seems an improved presentation ??

Last Sunday, several of your own posts, those that occasioned my reply, were also removed. Re. rows, indeed I have pointed out you being ''at the centre of most of'', but never ''ALL'' of, and I have never posted , ''and always will be''. I did post ''twas ever thus'' which is different. Thanks for this admission, ''Maybe he had a case''.

I'm glad that you are well enough to post prolifically and ATB with engagement No. 7 - you are a one ! I don't ''have a deep personal'', on the contrary, but I will persist in defending myself against your 'demonisation' process so please leave the 'bitter' and move on.

So moving on - you now say of the 'derampers', (which happily cannot possibly include me (smiley face)) - ''believe me they are working very hard to create a hate campaign''. Methinks you doth protest too much. OTT !

TCOY

Keytruda - ''significant improvement in OS compared with chemotherapy alone in certain patients''. It will be interesting to learn what CRUK find out in Combo with SCIB2 - in due course !

''Cancer drug Keytruda can now be used as a first-line treatment for patients with stage three non-small cell lung cancer (NSCLC), whose treatment options are limited. The US Food and Drug Administration (FDA) has approved Merck & Co’s Keytruda (pembrolizumab) for patients who cannot have surgery or definitive chemoradiation, or who have metastatic NSCLC with a PD-L1, or certain genetic mutations.

Dr Jonathan Cheng, vice president, oncology clinical research, Merck Research Laboratories, said: “This expanded first-line indication now makes Keytruda monotherapy an option for more patients with non-small cell lung cancer, including those for whom combination therapy may not be appropriate.” The expanded use approval is based on results from a phase 3 trial, in which overall survival (OS) was sequentially tested as part of a pre-specified analysis plan. When used as a monotherapy, Keytruda demonstrated a statistically significant improvement in OS compared with chemotherapy alone in certain patients. The randomised trial, which involved 1,274 patients, showed that the frontline treatment resulted in a median overall survival (OS) of 16.7 months, compared with 12.1 months with standard chemotherapy in patients who had advanced or metastatic NSCLC and a tumour proportion score (TPS) of =1%.''

https://pharmaphorum.com/news/fda-expands-keytruda-approval-nsclc-treatment/?

''Black hole seen for first time in image showing matter being sucked into timeless oblivion'' . . .

(DT headline)

I know the feeling as a devoted LTH here !

But it'll see us through - the science not the black hole or maybe . . . . .

Ruck - IMO the main factor for SCLP prominence in the 'Chat charts', is the number of prominent 'quabblers' who figure here . . . .

But when there's news or something to really examine and discuss, this BB IS great !

That's not right now unfortunately . . . but more blue please !

I had 'catheter ablation' inside my heart in 2013 and was eating lunch 30 mins after waking up. I know your issues are much more serious than mine were, but the process itself may not be as bad as you might fear. So good luck with the new treatments and I hope you get some real benefit.

You may be sure that ALL on the BB's have always been and will be now, rooting for you . .

Even the 'black sheep' that is - Good Luck C7.

. . . . elsewhere :-

''An experimental cancer “vaccine” showed promising results in a small clinical trial of patients with lymphoma, according to a study published Monday in the journal Nature Medicine. Researchers at New York’s Mount Sinai Hospital tested the treatment in 11 patients with lymphoma. Their results were successful enough to warrant another clinical trial in March on lymphoma patients as well as breast and head-and-neck cancer. Researchers said some patients in the initial human trial went into full remission for months or even years.''

https://www.cnbc.com/2019/04/08/cancer-vaccine-shows-promise-in-human-trial-of-lymphoma-patients.html?

The treatment involves injection into the tumour itself ? A little problematic and painful !

Wish you a good night's sleep Inan ! Maybe a big RNS 2m LOL