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There is a massive medical centre in white house 15 mins away... its all about what it looks like if hes in hospital... bit sad for the mi ions who have to work in white house who are probably scared stiff of getting infected given the number of journalists falling like flies,... one thing is for sure if he gets worse, the only option known once you have been given dex is intubation on icu so it doesnt sound as if he is acutely in danger of that. In the trials 75% on dexa did get better. 25% died. Depended how many co- morbities they had. I think most people are on dexa for a week and it goes one way or the other... he seems to be recovering.
Pmjh... if You are on dexa, its because you are trrying to stop your body attacking its organs.. ie damping down the immune response. Interferon does the opposite to this by iNcreasing immune response.. I cant see how trump will be given syn as if he is on dexa, the additional interferon would finish him off.... dont get why everyone seems to think this is a possibility? Seems very unlikely now he is on dexa.
Dib... its only given to serious cases - but it works in 3/4 cases... so he was / is serious but is responding. Not given earlier in mild desease as would kill immune response and thus kill you. Its the opposite of syn.
Dibs, not quite... DExa is normally given to suppress immune system when it is close to or already is in a cyto storm - which is why you cannot give Interferon beta at that stage. Interferon beta is the opposite and encourages immune response. So you normally give Dexa when you want to lower not enhance immune response due to other organs being attacked. But it does work - albeit has much higher death rate - but he seem to be responding to it.
for my girls... i'll split the cost with you.... maguire has head elsewhere; lamela should have gone too though. Ref has ruined game. tit for tat. goodness knows what Ole can say now.
Trump being on Dexa is serious as only given when on O2.. normally means has progressed outside lungs... if they gave him Syn it would kill him is my guess as he must already be close to a cyto storm to get Dexa so you dont want any more... but sounds like the Dexa is working.... who cares though as looks like he'll be gone in 4 weeks then he can chill out and recover): and will have a reason not to lose face.
Sorry Manifesto... you are right... they are running seemless phase1/2/3 trials
https://investor.regeneron.com/news-releases/news-release-details/regenerons-regn-cov2-antibody-****tail-reduced-viral-levels-and
which are somewhat bigger than those of Syn... we could really do with Syn producing this stuff and getting emergency use to scale up trial to 1000+ asap. I think that is what he is working on so i suspect he cant go any faster than he is as RM must see what needs to be done.
Then make it considerably shorter if you want him to read it and people respond much better to praise than being told they are numpties... really appreciate you making the effort and this is just a tip.. but this is what i'd write...
Suggest anyone also looks at the twitter accounts of those mentioned...
The Secretary of State for Health mentioned Synairgen Covid trial in the HoC on 20th July 2020. This is known to be a safe medication and appears to be highly effective. It also works against multi-viral cases such as flu and Covid together
It is known to be effective on its own and may make other drugs currently being indicated more effective. It boost the bodys' own immune response which the virus knocks out. Thus it can be used alone or in combination with other drugs. Synairgen have a unique formulation which makes it easy to administer in home or hospital.
I have heard that France is about to grant Emergency Use Authority to Synairgen. There is a limited supply of this, sourced in Southampton and i am concerned that the government need to step in and help secure supply from this British company. Whilst i know you are busy can you please confirm you are on the case of this directly. I know that Lord Bethell and Lord Crisp (former CEO of NHS) know of this and i would imagine would welcome further support.
You can imaging the concern and frustration amongst your constituents at not hearing anything further from the Secretary of State since July 20. Please may I respectfully request your very urgent assistance in this matter. I can provide further data on request.
https://www.bloomberg.com/europe
Pretty good picture of who is now testing positive... and how the virus is seriously contagious.
the biggest issue with regeneron is that it was primarily tested prior to virus entering lungs ie very very early. To stop entering cells. However, given current testing and instructions to self isolate until you are sick, then too late for regeneron and you move onto better drugs to control replication or immune response is the general current thinking. So its currently, with current knowledge a continuum:
Stop it : Vaccine
Stop it moving to Lung! : Regeneron
Stop it replicating in lung: Remdesivir
Boost the cavalry: Interferon beta or blood transfusions
At deaths door: Dexa.
That is current thinking summarised. Depending if you are third world or first world directs which is most likely as well and if you have the wrong genes you are probably ****ed. (genedrive)
Guys, this board is getting too far away from facts...
Regeneron is used before the virus enters the cells - i.e. very early.
Once it enters cells you want to a) lower speed of replication (with remdesivir or similar) and b) increase your immune response (with interferon beta). If this is all too late or doesnt work as you are too ill, then you get dexa.. when virus starts to attack other organs.
We aren't being sidelined. Chill out guys and gals.
Why would you give a strong anti-viral drug to someone who might not need it?
If he needs it, i'm sure he can get it. Its not aspirin you might just pop for a headache. If hes producing a ton of antibodies then you dont want to increase that into a cytokine storm to finish him off as the docs would be done for manslaughter, its too high profile a patient.
Syn has to scale up which is what they are doing and their latest announcement said they had realised this back in March and were doing so for this Autumn.
Gkb...regeneron is pre viral invasion of cells so you'd have to catch really early - they pribably just wanted to slow progression. They probably then waited for test Results on how many antibodies he was producing and started on remdesivir to slow the Rate of virus multiplication. They will then discuss in hospital looking at frequent antibody test data whether they need To give him stuff to increase his ability to produce antibodies. Should think that's what is happening now. Doubt its any more complicated than that. He will probably recover and give himself a thousand golden stars for securing for the usa the global supply of remdesivir. Sounds to me Both remdesivir and syn need to scale up asap to meet global demand. Bit sad for third world who get the cheap dexamethasone When their organs are starting to be attacked... Hopefully between bill gates and the pope they can sort out both remdesivir and synairgen for the poorest imho and china dont try to do some dastardly deal on country loans repayments for cheap alternatives.