Some basic sums23 Sep 2025 20:51
“There are no global statistics available for the annual diagnosis of relapsed/refractory acute myeloid leukaemia (R/R AML) specifically. However, a study analyzing the global burden of all AML from 1990 to 2021 showed a significant increase, with 144,645 new cases diagnosed worldwide in 2021. Estimates for the United States alone in 2025 predict 22,010 new AML cases, but these figures encompass all AML diagnoses, not just R/R cases.
The average drug costs for relapsed/refractory (R/R) adult AML in the US vary significantly, but a 2019 study found the mean outpatient pharmacy cost to be approximately $24,640 to $30,909 per patient episode, while another analysis reported a median total adjusted direct cost of $116,384 per episode, with pharmacy costs as a component. Newer targeted therapies like enasidenib can cost around $120,131 per course, highlighting the wide range depending on the specific drugs used, with hospitalization and supportive care being major cost drivers overall.”
So even if about 1/3 of patients worldwide use the new product that's about 50,000 treatments. Even if they charge half what enasidenib costs in the US, US$60k, that's US$3bn in revenue.
Now I don't know how much it costs to produce the new drug but that must be considerably lower than US$60k. Say US$20k as a guess. That's US$2bn profit a year. Yet current mcap is just under £78m. R&D costs have been raised so I've ignored these.
Even if I’m 90% out you’re looking at a profit of US$200m with share price of £274.28 (£147.95m profit, mcap £1.47bn = 10 P/E ratio). BTW a typical or "normal" P/E ratio for major pharmaceutical companies is around 20 to 25.
Conclusion, there’s huge upside here even after the 700% rise since end of August!