Member Info for sadoldgit

Nudging close to 15 dollars a share at the moment at 14.85.

If there was a takeover, and that is a very big' if'. Milestone payments from Sierra would need to be known, as also to the continuing trials of SRA 737. We should hear soon of an update and/or intended trials of the progression by Sierra.
The hold up has been Sierra seeking alternative non share diluting fund raising, so clearly they have a financer. They have hung on to the very last minute.

The Chinese unlike Sierra will have the funds to progress. Our FLT3 is a very under rated compound. 900k milestone is peanuts for what they have to gain irrespective of being used in the treatment of Covid-19 or not.
Regards all

Yes Andy, crystal clear and good news in that respect, although nowhere near the payment that was expected, it will be circa 400k in the bank. At the very least it puts an end to all the bu..ering about by Sierra.
Flt3 should put another 900k in to the coffers in January.

Regards

CPF in due diligence would be enquiring whether Sierra have access to funding to progress or at least their ability to fund. The sooner the better the ball starts rolling the better.
Tyk2 will be hot on the list as nearing the end of preclinical.
Flt3 we also due news very soon.
There are big buys and as the saying goes follow the money.
Regards

It is good news if you look at what is behind it. It will enable SRA737 to be progressed. Non dilutetitive funding must now be made available. This has been negotiated between CPF the owners and Sierra Oncology. The upfront milestone has been hammered a bit but overall by 10% reduction, this is reflected mostly in up front payments. Get SRA737 developed, the sooner the better for all concerned.
Regards

An agreement of financing of some sort for SRA737 must now be in a late stage of negotiation. That is if Sierra are choosing to keep.
Regards

Pleased for you on that one elcap

Agree. I will not be renewing my subscription with them.

Yes, a multi pronged approach is necessary. There will be people who will still fall ill. There will be at some time other viruses causing similar problems. It certainly does not mean that a Tyk 2 Jak 1 inhibitor cannot be used in the treatment. Most Biomed stocks have taken a bashing over the past couple of days especially if there is the slightest relation to them being involved in work for Covid-19. There will just not be enough vaccinations to go round for everyone this time of year. If they chose to vaccinate front line workers at first and those most at risk, then those most at risk of developing severe symptoms will be a good test for the vaccine.

That does not rule out the use of liquid nitrogen for cooling , I have use liquid nitrogen to keep cold germanium detectors on gamma spec machines on and off for over 30 years. Lab freezers in most cases dont like much going below minus 75 and as you say 20k for a 12 litre one. Look at paying over 150k plus to take it way way below minus 80. Liquid Nitrogen boils just below minus 190 and can be kept for a while in Dewars.
Enough of that. Very decent of LSE to get the chat back up and running.

Why would you need soldiers in car parks for liquid Nitrogen?

For storage you can use liquid nitrogen to assist.

Good morning all and have a good day before the chat function on LSE gets shut most of the day!

I think the phrase is market sentiment. It has not made Sareums compounds any less effective.
Next thing they will be doing is chucking all the ventilators out of the hospitals. There will be a massive supply of toilet paper build up in supermarkets and it will all just seem like a bad dream.
They will still need test kits and still need effective treatments.

Generally speaking vaccinations are typically a weaker form of the virus. A preventative measure in that you will then be immune from contracting the virus or if you do get the virus you will have built up antibodies.
All sounds good. if they use this route. Should the virus mutate for the worse, ie become a more dangerous strain( which appears to have happened with the mink and the culling of), or should there be a similar corona type virus outbreak, the vaccination is basically useless.
As for the heavy SP drop here in the bio research area. it makes me wonder what will happen with drugs like the Black box Remsdisivir and similar treatments which have not conclusively proven to be effective.
Covid 19 aside there is still masses of potential here with Sareums 1801 immunotherapy and 1802 oncology inhibitors. They have other inhibitors too of similar TYK2 compounds which we know very little about.
FLt3 is in China being progressed and should hear of positive news soon and of course our long awaited milestone payment of circa 5 million pounds milestone when Sierra get their bottom into gear and get funding sorted. It has been planned by them for well over a year!

Jak2 and Jak3 are considered responsible for the dreaded black box warnings of severe side effects.
Tyk2 Jak1 is more selective.

Secondary bacterial infections induce 1L-1beta and GM-CSF ( Granular Macrophage Colony Stimulating Factor)

1L=1beta- GM-CSF pathway is blocked by virally induced Interferon alpha and Interferon gamma;

Tyk2 Jak1 inhibition blocks IFNalpha/gamma signalling hence restoring GN-CSF levels

GM-CSF signals via Jak2, so Jak2 is likely to undo the effects of restoring GM-CSF levels

It therefore suggests that a Tyk2 Jak1 inhibitor that does not inhibit Jak2 to be 'optimally beneficial'

Sareums 1801 and 1802 inhibit Tyk2 and Jak1, but NOT Jak2

Taken from

https://vimeo.com/reecemedia/review/410074815/6d403ad260

Regards all, for the newbies at least read and digest the above article.

Virus mutation is explained here much better than I can explain

https://www.medicinenet.com/when_covid-19_mutates_what_are_the_risks-news.htm

Prof Eleanor Riley, Professor of Immunology and Infectious Disease, University of Edinburgh, said:

“With the best will in the world, this vaccine – or any other vaccine currently in trials – isn’t going to change things for the majority of us this winter.

“If we can start vaccinating the elderly and otherwise vulnerable, as well as NHS and care home staff, before the end of the year at the very earliest, it will still take time to roll it out to enough people to substantially reduce the pool of highly vulnerable people. Also, this vaccine needs two doses, three weeks apart and it will take at least a week after the second vaccination before you are fully protected. So even if you were vaccinated today, you couldn’t be confident you were immune for at least a month. Finally, we don’t know if the vaccine simply reduces symptoms or whether it prevents infection? If not, maybe it nevertheless prevents or substantially reduces transmission? We don’t know yet.

“So, we all need to accept that the current public health measures are going to remain in place at least until the end of the winter, possibly longer. But if this vaccine lives up to this early promise, and other vaccines work equally well, we may be able to look forward to a much better summer and autumn in 2021.

How effective could it be?
A vaccine - alongside better treatments - is seen as the best way of getting out of the restrictions that have been imposed on all our lives.

The data shows that two doses, three weeks apart, are needed. The trials - in US, Germany, Brazil, Argentina, South Africa and Turkey - show 90% protection is achieved seven days after the second dose.

However, the data presented is not the final analysis as it is based on only the first 94 volunteers to develop Covid so the precise effectiveness of the vaccine may change when the full results are analysed.

Dr Albert Bourla, the chairman of Pfizer, said: "We are a significant step closer to providing people around the world with a much-needed breakthrough to help bring an end to this global health crisis."

Prof Ugur Sahin, one of the founders of BioNTech, described the results as a "milestone".

Novacyt were down 50% at one point and Avacta 33%. Test kits will still need to be used a vaccine is not the be all and end all The vaccine 90% works on people. What will the remaining 10% have to look forward to?
Early stages and I do not have much faith in the Pfizer vaccine. More than one type of treatment is required.
Regards