Member Info for sadoldgit

Good evening Belhus. I don't think Gilead holding Sierra back. My belief is Sierra not have the 'alternative form' of finance available to continue SRA737. I think they want to keep it until they have unloaded Momelotinib. It was in October that there was an agreed reduction of milestone payment with the expectation of pressing ahead with development and further trials. Since then achieved Jack 5 hit. It does not appear that the CPF are overly concerned either.

TYK 2 will be hot, but there will be pharmas wanting in for peanuts. The potential of TYK2 has not been realised yet. How do you price that? What is Tim an co willing to accept? Should 1801 be suitable for the treatment of Covid 19 then you are looking at many many multiples of the current SP. Even an update with regards to fast tracking 1801, will have a significant increase.
All we get is we are in discussions. It would be good to know who with, but of course that is not going to happen until a biggy of an RNS drops. As to when is nothing more than a guess.

Regards

Unite. The current value of the market cap is circa 60 million. A pharma is not going to be able to buy the company for 60 million. If you can't understand the reasons for this with the pipeline that Sareum have then you really need to go away and do a bit of research yourself.
There is an element of risk, we all know that, as well as the element of reward. Most on here are aware of the pipeline of products that Sareum have and are happy ( most of the time) with the potential that the SP has. as is also to the benefit that the inhibitors have to various cancers and immuno diseases to sufferers.

I suggest you have a good look through the Sareum website and read up what has developed over the past 7 years plus.
By the way, where are these free shares you refer to?
Regards

Hi elcap. I don't think persons will be dumping this afternoon. Not many trades today and no news released. Very little point in the 'dumping' with the potential it has over the next few days/weeks.

One of the points I take in and I don't think fully realised is Tyk 2 1801 and 1802 virtually no toxicity at 30 times dosing levels ( yes I know t0 establish MTD) Yet dosing levels of the 1st generation TYk2 Jak1 Jak 2 and Jak 3 carry a black box warning. In addition they have formulated compounds to be taken in much larger dosages which suggests not too much of a problem with compound as with FLT3 . Surely Sareum must now be on the radar of large pharmaceuticals.
All in all a good watch.
Regards all LTH and not so LTH

it may be up or down a little, the certification has been granted on the mask. This is a major obstacle overcome. The derampers will have thier job cut out to undermine the mask progress now.
Next obstacle is the machine to be up and running and spewing out masks to specification.
An RNS informing us that the machine is up and running trouble free and you will not see south of 5p anymore. Significant growth in Market cap as orders and production increase.
All in my opinion of course.
But I will add that to me it is a 'no brainer'
Forecast to open up on Monday at 3.2 to 3.3p

Regards all

A god post by RMM. The vaccines are not all what they are made out to be. As a rule with flu it is seasonal hence flu jabs for the most vulnerable at the end of autumn. This bugger is here 24/7. Like all viruses it has the ability to mutate. The Covid 19 is mutating all the time. It would be naive to think that a vaccine is a be all and end all. It will assist. What happens should people be vaccinated that already have the virus yet test negative. Will this in itself result in a far more resilient form of Covid-19?

Eventually, herd immunity will develop but that most certainly is not going to happen any time soon. The common cold has over 200 variants. just because you have had a cold it does not stop catching another variant. This must also be true of the corona virus, as it is what it is, that is a virus. Hence should more people catch Covid 19 the more it will mutate. Long term health problems are the consequences for many who have contracted and survived the virus. This in the future will place a phenomenal burden on our already way over stretched health service.

Limiting the spread of the virus by the use of good hygiene practices and RPE, vaccines and lastly but not least, one of the most important, if not the most important is the early diagnosis and an effective treatment at an early stage for patients.

If there were an effective treatment that can be used on those that are likely to develop the worst symptoms and signs then the country could start reducing lockdowns and get back on its feet. Until an effective treatment is found whether it is Tyk 2 or any other pharmaceutical kinase inhibitor then it is very unlikely that we will pass the worldwide peak of this pandemic in the next few years.

Regards all

Glenfidrich, it is all in the the name TraderTzes!

Trader tzes. No it has not touched a nerve, but with they attitude in your reply it has definately appeared to have done so in your case. haha
'The FACT is that they do not need to remove a drug from their advertised pipeline in order to seek partnership'. What relevance is this claimed fact of yours? If it not shown in the advertised pipeline then clearly it is not for sale. The question we ask is why?

Trader tzes. You also need be able to understand the renegotiated agreement with Sierra were made by the CPF and not Sareum, Sareum have a monetary interest/royalty payment only and as such have very little sway in the matter.
I would add however, that in my opinion which of course is not factual that Sierra are pushing Momoletonib. I would hazard a guess they are intending selling this prior to pushing along with the CHK1 inhibitor if they cannot obtain a source of alternative funding, It is not shown for sale as clearly they chose not to sell it, clearly being aware of the vast potential it has.

Tradertez, Since when has your opinion been a fact? I am appalled at the misuse of the word 'fact' clearly by people that do not know what a fact is.
'I think people need to come to terms with the fact that nothing is going to happen with Sierra and SRA737 any time soon and stop looking at it through the rose tinted glasses.'

1735 hrs

Strange the 500k buy after hours at 2.55p
I wonder what it will open up on Monday at. Added a piddly 150k only at 1.6p. Just woke up after my night shift.

Added at 1.6p

Fowldzy, 1 man 1 machine. Will that man be working 24/7? Most likely will be run on a shift rota.
regards

yes 0.5% being one 200th of 100% and 10 million being approx one 200th of 2 billion

good morning working in pharma. It would be the icing on the top of the cake for the US patent grant for 1801. That as the yanks would say is a tough cookie to catch. I think we will get there it is just the time frame. In a matter of weeks would also expect an update with regards to its use in Covid 19. I reckon these two are the last big hurdles to overcome. No question then as to an interested buyer if and when protected by patent and or suitable as treatment for Covid. All loooking good and just a matter of dotting the i's and crossing the tee's.
Getting close to 10 years here now and not as long as some I know. The 10p party was talked of years ago, with the potential of all four compounds it would not be out of the question to think about a £1 party, but think many will be gone by then.
Regards

Another hurdle jumped. Patent protection worldwide. Another niggle resolved and no longer available for compromise on price for any pharma that is serious in buying i would say the price has now gone up considerably. A few weeks away I would think for a billion pound price tag for TYK2 compounds irrespective of the Chines flu. Yes a great year coming up for Sareum and all invested here I feel.

Regards

Only a complete and utter moron would continually deramp a share then state that they would have to be a moron to invest here if they had not shorted it. One sided to suit their agenda

Ahfam ! 10 out of 10 rodents were not cured in the trial. 10 out of 10 rodents all had greater than 98% tumour reduction which is not quite the same. 1 or 2 mice had complete recovery, but bare in mind it was only 1 28 day cycle of treatment. Aurora plus FLT3 was sareums jewel in the crown picked up by the Chinese for next to nothing as we know. ADME was excellent. A top notch inhibitor shelved due to lack of funds as used to concentrate resources on TYK2 compounds.

News due soon.
Regards

Good morning GlenFidrich. I don't see any problem with solubility issues. As Tim stated Sareum did not have the scope and resources to resolve solubility issues ( I am presuming here large batch) A lot of this will come down to finances as Tim and co dont have inhouse resources. A lot of money required to outsource, which sareum also do not have. The Chinese pharma will have in abundance.
I did say 6 months ago along the same lines that the Chinese pharma have picked up Aurora FLT 3 for nigh peanuts and a bargain of a lifetime, It was Sareums jewel in the crown and nothing has changed. It was shelved due to funds being concentrated on TYk 2 1801 and 1802 Excellent ADME and toxicology issues as with all other Sar compounds.
Regards