RE: Morning All10 Mar 2020 08:32
Lindy's talk sounds very familiar.
"Lindy Durrant, PhD, Professor of Cancer Immunotherapy, University of Nottingham; CSO, Scancell Ltd."
"Citrullination is a widely expressed, novel, stress induced post-translational modification that is a potent target for cancer vaccines. There is a repertoire of cytotoxic CD4 T cells in mice and humans that recognises citrullinated epitopes. Tumors over-express PAD enzymes. Inflammation and stress induce high levels of autophagy and MHC-II presentation of citrullinated epitopes on tumors. Citrullinated peptides demonstrate potent anti-tumor immunity with no associated toxicity and will shortly enter the clinic."
And a good high level summary of what Moditope is all about.
I hope we do get her talk on Youtube and/or the Scancell website. There is always something different to find in Lindy's talks as the science progresses.