Member Info for PL75

Evening, I know what you’re thinking, ugh, another one... WBernard, I’ve looked back through your posts on avct as far as I can and couldn’t find any links to any journals. I think we’d all appreciate you posting them if you’d be so kind, KK has started the thread over there. There’s no debate that an LFD is as accurate as PCR testing, but a debate on the LOD and usefulness of an LFD could be of benefit to everyone (investments aside). Sorry for the interruption all...

Thanks

Unless a suitably high number is put in front of Sir Al, I’m pretty sure he’s focused on other matters than M&A at the minute

As you rightly said, no test will detect a single virus particle so the dream of 100% is nonsense. We need the LOD to be practical, the actual percentage is irrelevant. Agree?

Thanks Ophidian, I’m happy with the logic of the test being useful to whatever LOD it reaches, and obviously let’s hope for the best. However, that doesn’t answer the question of viral load versus contagiousness. For example, asymptomatic nurses testing themselves daily, could we have a negative result for someone that’s contagious? Or does the LOD correlate with the viral load that could result in it being spread so we would catch 100% of contagious people, even if the technical LOD is lower?

I’ve asked this multiple times but not really got anywhere. In my noddy admittedly uneducated brain, the LOD does not dictate if we end up with a useful/useless test unless it’s absolutely hopeless. False positives are never a problem, they’ll just isolate so let’s ignore that. False positives are. But... let’s say we end up with an 80% accurate test. The LOD determines the cut off of where our test is 100% reliable. There is still huge value in this. Without any mass antigen you have 100% of potential spreaders out in the open. With an 80% test, 80 out of 100 will isolate. That is still hugely beneficial to keep the r value down.

My question is do we understand how the LOD correlates with the viral load when someone becomes contagious? If our LOD is above it, then we’re in business. Obviously the viral load in patients will increase as it progresses, but that’s the point of the test, it’s a mass test and should be used very regularly if you’re on the front line or mixing with people. Take the test regularly and as soon as you find you’ve got it, isolate. The r value is kept low.

Can anyone answer and does that make sense?

I prefer your dodgy calculator to 54s accurate one

Evening all,

On Monday, Sir Al said he was popping his affimers in the post. I assume Cyvita are working on the LFD in the US. In that case there might have been a lag there, rather than them just being slung over the fence by Yodel.

But Sir Al also said a few weeks, so 2-3 weeks? 1 week down, a max of 2 to wait for a prototype?

I would say no news due next week, but Sir Al does like surprise RNSs.

Yup, he’ll say that once he’s ordered a few billion of the American Cyvita LFD Saliva tests

Yeah, I read that, it’s as good as useless for frontline staff. Might as well toss a coin

Him/her? I keep changing my clothes, it’s the weekend after all

You need to post that on their board, they seem to like that sort of thing

I'll try replying to this thread...

An exceptionally good point O&W. Sir Al spoke of not wanting to halt progress elsewhere despite having to defer cancer trials to Q3 for obvious reasons. Once we've selected our favourite from the pharma beauty parade that will be queuing up for Covid we'll then have 2 trials of Avacta's treatment division underway and the latter funded by someone with deep pockets to boot.

Sir Al is a genius.

Your post was great too xx

I on the other hand am not a genius, having replied to the wrong thread

An exceptionally good point O&W. Sir Al spoke of not wanting to halt progress elsewhere despite having to defer cancer trials to Q3 for obvious reasons. Once we've selected our favourite from the pharma beauty parade that will be queuing up for Covid we'll then have 2 trials of Avacta's treatment division underway and the latter funded by someone with deep pockets to boot.

Sir Al is a genius.

Minister of Innovation at the Department of Health and Social Care.

Yet he isn’t capable of using Google. Shocking he wasn’t already aware.

Here’s hoping they work... https://www.theguardian.com/business/2020/mar/30/cheap-covid-19-test-kits-for-ocado-staff-may-be-unreliable-union-warns

It shows that the market for corporates could be incredibly large once Avacta’s 10 min test is available

Chengdo...yodaforce... Retired... Agreed

Sir Al called them out, the RNS was a huge calling card for the big boys. He has said these conversations have started so the pipeline of substantial significant newsflow is getting bigger by the day. It’s also a neat strategic move to partner with multiple global giants for the different lines of attack, it’ll encourage a healthy bidding war if anyone fancies a cheeky early bid