RE: Great OBD CiRT Q+A on Presision Medicine website today9 Jan 2024 23:21
It looks a very big market Dug, and as you say it makes OBD a target for the major pharmas. That would be good for cancer sufferers as well as the testing would become more widespread with more patients benefiting from what is important therapy that they might not otherwise get without a CiRT test confirming they should benefit.
I had no idea that ICI therapy cost was so high so an increase in the number of tests to see if a patient is likely to benefit or not should, in theory at least, be driven by the insurers given that, unfortunately, three-quarters of sufferers won't benefit.
BUPA taking the test is a good start but you'd think the U.S. insurers would be eager to include it and insist on a CiRT test before giving the green light for the circa $100,000 treatment spend. It flags up those that would seemingly benefit but in reality, wouldn’t and undergo non-beneficial treatment which isn't helpful for the patient or the insurer.
From a cold financial perspective the insurers might not like the 17% of those with a negative PD-L1 who could benefit from the costly treatment when, previously, they would be excluded. It seems as if the test is going to rule more out than ruling unanticipated ones in. So, financially, getting as many tested with CiRT would appear to stack up from their perspective.
I like to keep my expectations relatively low and lowish monthly test numbers are still material to OBD. 500 CiRT tests equate to close to breakeven for OBD. The number of doctors selling it (50) won't increase since the June monthly figure but, you never know, the figures might be higher than my 200 to 250 best guess.
Jon Burrows said the plan for the PSE test was to launch and validate and ultimately partner with a major diagnostic pharma or lab. With CiRT they may have the same plan and they will be well down the road of validation and ready now to partner with all the data for an optimum deal. A takeover does seem to have an air of inevitability at some stage.
It's arguable that if an unexpectedly high number of tests were currently being done then an announcement would have to be made as it would be material. On the other hand, OBD hasn't given forecasts and given that nothing has been forecast there is no need even if the figures are currently very decent. Not long to wait to find out.