Member Info for Muck165

Thanks notsosmart

It seems to me that Saturn Pass are looking to have an app to record test results and I suppose potentially collate results centrally.

I think this is key to the whole process but personally I really hope AVCT use a different service - could be BBI Novarum. There is a great little video on the BBI site explaining it

Can I just check my (basic) understanding of the current players and their roles?

-Avacta - make the affimers that are central to the test
-Cytiva - create and optimise the membrane, create a prototype, and produce manufacturing procedures for the test. Produce analytical validation of the test.
-BBI - lead manufacturer. Appointed to develop and validate a scaled up manufacturing process, ie to take the process Cytiva give them, stick a rocket under it to create volume, use the process to make it themselves, and (hopefully) transfer that scaled up process to other manufacturers (yet to be announced).
-CONDOR - assist with rapid clinical validation of pilot batch tests produced by BBI
-LSTM - also assisting in clinical validation through access to additional live samples
- Medusa19 - exclusive B2C distributor. Can also supply businesses
-Saturn Passport - not really sure they have anything to do with us directly

So, if this is all correct (it may not be!), then the clinical validation is being completed at the same time that BBI are finalising the manufacturing scale up process, such that we should be in a position to produce through BBI as soon as the validation is complete. We are hoping that govt procurement talks will be at a very advanced if not final stage by that same time, and that they will be buying the first batches. I’m assuming we would then name other manufacturing partners and transfer the scaled up BBI process to them, so that we can meet the anticipated very high global demand.

Would be grateful if anyone can tell me if this is right or wrong...

Thx

https://www.firstpost.com/india/saliva-based-covid-19-diagnosis-is-cheaper-and-faster-compared-to-swab-testing-say-scientists-8741721.html

It seems the game changing value of saliva rapid tests is becoming more and more apparent globally

We probably all need to get tested PAH00 - sure Sir Al can come up with something

See below a question posed as part of parliamentary business yesterday, and responded to by Lord Bethell

https://www.parallelparliament.co.uk/writtenanswers

Written Question
Coronavirus: Screening
20 Aug 2020, 12:26 p.m.
Questioner: Lord Turnberg

Question

To ask Her Majesty's Government what plans they have to extend COVID-19 antigen testing to the entire population.

Answer (Lord Bethell)

Anyone with COVID-19 symptoms can get a free test and must get tested as soon as their symptoms develop. The swab test takes less than a minute, is pain free and results from test sites are received within a day of the test being administered.

The Government has put in place the largest network of diagnostic testing facilities created in British history. The programme achieved the capacity to deliver 100,000 tests a day by 30 April, 200,000 tests a day by 30 May and is now capable of delivering more than 300,000 tests a day. We are committed to increasing this capacity to 500,000 by the end of October.

Here’s the actual announcement for those interested

https://www.hhs.gov/coronavirus/testing/recission-guidances-informal-issuances-premarket-review-lab-tests/index.html.

As AfamaMan pointed out earlier, it confirms that any company electing to bypass the FDA would not be eligible for PREP Act coverage (ie legal immunity).

https://www.usnews.com/news/health-news/articles/2020-08-21/white-house-blocks-fdas-power-to-regulate-lab-tests

Because they need the stock?

GAZA - yep that looks like the teacup test he was talking about.

Dr Bell also talks about pregnancy style tests between 18.37 and 19.52 in the interview, explaining that these will allow saturation testing in the way that Julian Peto has suggested (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30936-3/fulltext) and that there is now quite a bit of modelling to suggest that this is the way to manage the infection.

Everything really is coming together here!

Ah, will duly ignore him PL75!

For info, Dr Bell names the manufacturer of the”teacup” test in the interview as Homodeus. You can get some info on this by plugging them into the company name filter at https://chs.asu.edu/diagnostics-commons/testing-commons, which tells you its a LAMP test with swab specimen collection, but I can’t find much else about it.

Anyone else have anything on them?

Clearly you have not listened to the whole interview

Agree 100% Gaza

Finally managed to listen to this - amazing! It’s actually pretty interesting to listen to the whole interview (more so the first half) - https://www.youtube.com/watch?v=WYpiFJJPP4s.

Apart from the obviously great comments about antigen LFTs, I noted his more muted response to population wide antibody testing and am really starting to wonder if BBI’s other U.K.-RTC partners (Abingdon, Omega, CIGA) may decide to switch some of their significantly ramped up LFT manufacturing services away from antibody LFTs across to antigen LFTs like ours. Certainly would not surprise me if AVCT announced a deal with any of these.

I haven’t seen this on here so posting for info

https://institute.global/sites/default/files/articles/Taking-the-UK-s-Testing-Strategy-to-the-Next-Level.pdf

I feel suitably admonished

Seeing as it’s a bit quieter on here now I thought I’d risk posting this (because it relates to SONA).

https://webfiles.thecse.com/CSE_Form_7_-_July_2020_Monthly_Progress_Report_-_SONA_.pdf?seCNI8zKS0LmitZqI__qLSDwO.eShg.W

It makes for an interesting read from one of our competitors, but I noticed in particular that;

-They don’t yet appear to have made a prototype test, which confused me because...
-They are going through the same kind of in field clinical evaluations that our LFT is presumably going through in conjunction with CONDOR
-That they have letters of intent signed with 2 purchasers for a total of 4.7m tests

Sona got 96/96 sens and spec in the lab. Whether they get the same results from the actual test is yet to be seen. Personally I think ours will equivalent if not better than this! It’s also a rod up the conk specimen collection (ouch), so nowhere near as consumer friendly as our gob in a pot.

Overall I think the link gives a bit more detail as to what’s involved in bringing these things to market, and gives a flavour of the kinds of initial orders competitors are getting.

But I reckon we’ll do much better than them!

Don’t shoot me for posting something not directly AVCT related!

https://www.aljazeera.com/indepth/features/rapid-coronavirus-testing-game-changer-200817073526707.html

Just a bit more info about what Rockerfeller and Arizona state are up to;

https://www.rockefellerfoundation.org/news/arizona-state-university-and-world-economic-forum-with-support-from-the-rockefeller-foundation-announce-covid-19-diagnostics-commons-to-help-companies-get-back-to-work/

(Sorry if posted before:))

Wiggly - it is really a great site to use isn’t it. That’s why I posted this on Monday

“Thought this was a useful site to see what else is out there..

https://chs.asu.edu/diagnostics-commons/testing-commons

Also interesting that if you apply filters to search for a self administered saliva based LFT then only one name comes up....“

Unfortunately I posted under the catchy title of “Useful Site”, so only a few noticed! Need to work on my marketing!

Great day today, and more to come! GLA

There are some very large delayed trades going through on L2, eg 500k shares, 350k shares, and plenty of 50k.

If we did have a seller, eg Miton, then I’m assuming the volumes today would have helped get them out?