Member Info for Muck165

I’m reading more and more about the potential of Mass Spectrometry as a prognostic tool for COVID - the latest example is https://www.medrxiv.org/content/10.1101/2020.12.09.20246389v1.full.pdf, which describes a study aiming to predict the infection severity in individual patients.

We also know that the coalition Perdita Barran set up in May is looking at the power of MS as both a Covid diagnostic and prognostic method, and that she is involved in the national Covid MS pilot.

It seems to me that having an accurate prognostic would be invaluable for clinicians following patient admission within the NHS, and help ease the burden on the health system.

What I have no idea about is whether or not the mass spectrum fingerprint produced by our BAMS test might have any prognostic potential, and wonder if there is anyone among us who might?

Of course, I may be barking completely up the wrong tree in which case I apologise!

Thanks

True, but I think that’s clutching at straws a little...

We’re beginning to hear that imports and so supply chains might become chaotic from 1/1/21 should there be no deal. This could include chemicals.

This may be a silly question, but does anyone know if such a supply disruption would have any impact on Avacta, or perhaps any impact on other test providers (RT-PCR for example).

MM order filling through the day...

Just an observation, but the note at the bottom of the piece says;

“Note: other technologies that have been validated will be added to the table once the manufacturer has consented to publication.“

Any ideas why companies with validated tech might not have consented to publication? I can only think it might be because they are public companies and would need to RNS prior to govt publication of the validation results, but no doubt others will have a more intelligent answer!

Ta

Dunno what happened there!

https://find-and-update.company-information.service.gov.uk/company/09714681/filing-history

https://s3.eu-west-2.amazonaws.com/document-api-images-live.ch.gov.uk/docs/B8REVUfflhT7S_4RvlGqfXowafyJw6sHZfhR0AqUoeo/application-pdf?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Content-Sha256=UNSIGNED-PAYLOAD&X-Amz-Credential=ASIAWRGBDBV3D5CZSWCD%2F20201207%2Feu-west-2%2Fs3%2Faws4_request&X-Amz-Date=20201207T071520Z&X-Amz-Expires=60&X-Amz-Security-Token=IQoJb3JpZ2luX2VjEIz%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCWV1LXdlc3QtMiJHMEUCIEDfTZ75ntlrEnHx7tttfhg%2BuRoKXNmGBRIzpKULHVJvAiEAuGWM%2Fd26P%2Fa4Wi4QkPJstlWheHIB1stMqXRaTvhr4yIqtAMIJRADGgw0NDkyMjkwMzI4MjIiDJkZBrHqUfNYv4HAGCqRA4LXpg5pa7HxRk2p2N%2F3L9LPA7vDfQ9piTH0%2BmxTOrMMl5A2kfpPMILT9YMchV6ZgowBsNG8IPKoEq%2Fnjd2ZnpxVUqvMv8sWm5qutO%2FvYgzh%2B7%2Bo%2BGlFBKWA%2FpzV04a%2B8NavUAfdRKcGPU16qCa0R9u5QmGLIHEv4xVggXh%2FOKsTRMqH5gBTiU6KRODYIAqTuPd%2BZROwIJs9dRQya%2Fb1xq26z%2F1FSo%2B2lh2PryzhLSkKxBSRTS7%2B0xwdgS27n9l4iRGRISWTEVaUihQqVAYWvhPrXnN6bLWi22J0Brffy%2BFSPsS9TAVo0HWhHQLLuFSYkrvUBenzNCmFNzOfnQc%2BDTJHeMrxquCbKzrvEKkGtG6dNn6ot%2Fxvb0lL8ySdhXGzYTH76uvQ1xRaAeSmecrZBik9Ed8RUhSSbcSzQEoFP1aDfgMia%2FgoWFdOENeMBxv7MM5jtnmDKQSlgNP6nxl2J%2BAwPEYoGWU2v5KyokJDt%2FnNOx284fMPhLsULZGlu7zq79fFK3NjW9F2uKTGwmdMqnu1MLTDtv4FOusBsz%2BdjXN%2FrtbWERwnCuXh5pzP129AeyzZNPAoDMJkl%2BStYevBKPUcEgJl8AfJvA8jfVpPffOhe7pYB552N6axvYksWuwF14xPzNtEzudPYcpIh86uS8xrrToJZFPZoVnQcXK%2BkHD1Eg6yO47lUPXhs8yTZoOuE2%2FnsGNby9EedD%2Fl6D%2FDECKVL9%2FYbXjaFje8RHLbjq%2By47bTO0Ga%2BCpmllm1uHSFBy%2FEvLj7uz52sYny1XuvCeKyX8mNJs5TraAb5hpIdTuVec71OHHOetDzMfn
Appointment confirmed at companies house

4s4pqiMbw8GQiIE5pcA22A%2BTTgj8U6olJgg%3D%3D&X-Amz-SignedHeaders=host&X-Amz-Signature=ee1f961e7d0c281e5fb202d79b6b04a00a57444b9a5b89f4f5b67bc87381d22c

Of where the UK is at with LFT testing in this parliamentary briefing note published last week (Presumably to keep MP’s up to speed)

https://post.parliament.uk/mass-testing-for-covid-19-using-lateral-flow-tests/

Re Innova - “ One test has been rolled out nationally, on the basis of an incomplete evaluation, and is discussed next.”

!!

https://www.theguardian.com/society/2020/nov/30/doubts-raised-over-rapid-covid-tests-in-plan-for-english-care-home-visits

AVCT and GGP have both seen similar things after hours today. Comment that it follows being admitted to an index...

Just had one too - called from 02036570059 if anyone else sees it pop up on their phone. Basically intro'd by saying they had noted my registration to a previous AVCT presentation and were wondering if I might benefit from their services more generally.

Another observation...

This interview with AZ and their BAMS work was published on 16/11 - https://www.news-medical.net/news/20201116/Affinity-Bead-Assisted-Mass-Spectrometry-for-Proteomics.aspx

Bruker tweeted about it on 23 November - https://twitter.com/BrukerMassSpec/status/1330889640128225288

If you compare theMatrix sprayer picture in the article, with the Adeptrix sprayer at https://www.adeptrix.com/store, then they like very similar. In fact to my eye they look identical.

Could it be that Adeptrix are selling to AZ (remembering that “BAMS” is an Adeptrix trademark)?

May be, may be not! Who knows!

Just an observation, but at Q21 of the FAQ on their site, Adeptrix confirm;

“The magnetic bead enrichment workflow requires only the standard lab equipment. In addition, a matrix sprayer is required to perform elution from bead arrays”

https://www.adeptrix.com/technology

Interesting then that they recently sold out of the Matrix Sprayers.

https://www.adeptrix.com/store

No problem ZB. As well as the points you highlight, I found it interesting that on 4/11 the FDA replied as follows re timelines for getting some form of home test authorised;

“I can't give you any timeline on that unfortunately, because that is dependent on developers submitting those EUA requests and making sure that they are - that the data is there to support that use. But we have, you know, as we've talked about on this call previously, we are very interested in that and we have put out information about, you know our recommendations as well as our flexibility to consider different approaches. So we are looking forward to getting to that point.“

but by 17/11 the FDA had authorised its first home test.

Anyone who has been reading these transcripts over the last couple of months cannot have failed to spot the very particular priority that the FDA was placing on home testing, and that focus appears to have translated from a position on 4/11 of not even having an EUA application to a position, just 11 days later, of having authorised one!

So the message seems to be that if we can tick all the boxes then the possibility of a very short EUA process is very real. To me, having the ability to manufacture at scale in the US maybe the biggest limiting factor for us.

The latest FDA round table transcripts are here (apologies if already posted)

https://www.fda.gov/media/143958/download
https://www.fda.gov/media/143957/download

I agree AI - seems to me that excitement is growing about both the diagnostic capabilities and the prognostic potential of MS

https://www.businesswire.com/news/home/20201125005954/en/Rosen-Law-Firm-Announces-Investigation-of-Securities-Claims-Against-Sona-Nanotech-Inc.-

We will open at £1.85.

Remember, if you sell then you crystallise you’re position, whether it be loss or gain.

Newbies be careful...

I thought Volz were supplying this, but I didn’t think they had a facility in Spain...?

https://www.londonstockexchange.com/news-article/RMS/update-on-p2f/14769651

Delay..