Member Info for mol42

Pushing staywell (doesn't have slimbiome) as new but released long before feelful - which at least is still advertised as new on undernoted though not as prominent

https://dailynouri.com/collections/best-sellers

https://www.instagram.com/reel/DKZ2gxjRPoJ/

mol

Feasibility study - 2023

https://research.reading.ac.uk/inform-innovation-hub/funded-projects/feasibility-study-assessment-of-wellbiome-prebiotic-to-improve-gut-health-using-mgut-a-novel-microbiome-nutrition-analysis-tool/

from

https://research.reading.ac.uk/inform-innovation-hub/funded-projects/

you will no doubt recognise a few names in the above link

mol

Results

The three prebiotics induced spatial-temporal changes within the gut microbiome. WellBiome® instillation was associated with compositional

changes to the microbiome, with increases in fibre fermenting bacteria such as Bifidobacterium spp. (mean log10 fold-change V1, 1.27; V3,

1.12) and Bacteroides spp. (V1 mean log10 fold-change, 1.28), and a reduction in known pathobionts such as Enterobacteriaceae (V1 mean

log10 fold-change -1.08). Instillation of a fibre with a low degree of polymerisation increased Bifidobacterium spp. (mean log10 fold-change V1,

1.55; V3, 1.2) and reduced Enterobacteriaceae (V1 mean log10 fold-change -0.85), whereas instillation of a fibre with a high degree of polymer-

isation caused a reduction in Bacteroides spp. (V1 mean log10 fold-change, -1.62) and Enterobacteriaceae (V1 mean log10 fold-change, -1.64).

All three prebiotics changed the fermentation patterns, with increased fermentation in V1 and V2, and a smaller change to the V3 fermentation

pattern. Upon withdrawal of the prebiotic, the fermentation patterns returned to baseline.

Discussion

Host microbiome-specific prebiotic-induced changes were captured using MiGut. Overall, WellBiome® conferred greater compositional

and functional changes to the gut microbiome compared to both constituent fibres given singularly. The increase in microbial fermenters

and the increased production of SCFA seen with WellBiome® instillation could be associated with improved gut health and greater immune

homeostasis4. The study showcases the utility of MiGut as a novel tool for evaluating the spatial-temporal nutrition-microbiome interactions.

mol

P 107 - Assessing the Impact of WellBiome® Prebiotic on Gut Microbiome Diversity and Function Using a Novel In Vitro model, MiGut

Sarah Zaidan1, Nia Paddison-Rees1, William Davis-Birch1, Adele Costabile2, Sofia Kolida3, Nikil Kapur4, Anthony Buckley5

1 University of Leeds, Food Science & Nutrition, Leeds, United Kingdom

2 University of Roehampton, School of Life and Health Sciences, London, United Kingdom

3 OptiBiotix Health Plc, Research & Development, York, United Kingdom

4 University of Leeds, Mechanical Engineering, Leeds, United Kingdom

5 University of Leeds, Food Science &- Nutrition, Leeds, United Kingdom

Introduction

Humans live in a symbiotic state with microbes that inhabit our body. These have a profound effect on our bodily function and health, with

the greatest collection of microbes located in the intestinal tract (the gut microbiota). Through metabolising the foods we consume, the gut

microbiota helps provide energy, maintain immune homeostasis, and can affect our mood. Through tailored nutrition, such as prebiotics,

we can improve the human-gut microbiota interactions to drive health benefits. WellBiome® is a mineral enriched fibre-based prebiotic

designed to enhance gut microbiome diversity1. We evaluated the effect of WellBiome® on the gut microbiota of 6 different individuals using

a novel in vitro model, MiGut.

Methods

We investigated the effects of either the WellBiome® fibre complex or two compositional fibres (fibres with either a high or low degree

of polymerisation) on the gut microbiome composition and function. MiGut is a continuous triple-staged in vitro model that mirrors the phys-

iochemical conditions of the proximal (V1) to distal (V3) colon, which captures the complexities of the gut microbiome2. Models (12) were

individually seeded with 6 faecal donors from healthy adults aged 40 years or over. The microbial populations were allowed to stabilised prior

to a 2-week period where the prebiotics were dosed once daily. A further 2-week period was included with no prebiotic dosing to assess the ro-

bustness of prebiotic-induced microbiome changes. DNA from the first and last vessels were extracted thrice weekly for targeted quantitative

PCR3. Short-chained fatty acid (SCFA) analysis was done by gas chromatography mass spectroscopy.

Results - following post

Adele at IPC 2025

24 June 11.45 15 mins re slimbiome (see also page 18) re rns today

also

24 June 13.10

aslo see page 20 and page 100 for Adele

but not noted within rns today

see also page 188 re Adele re wellbiome

https://probiotic-conference.net/wp-content/uploads/2025/06/ipc2025-proceedings-abstract-book-a4-r21-FINAL.pdf

just search pdf for costabile and you will find the uppernoted references

mol

Full article here

https://link.springer.com/content/pdf/10.1007/s00394-025-03732-8.pdf

mol

Https://www-fortunegreece-com.translate.goog/article/i-nea-tasi-stin-omorfia-legetai-ipnos-kai-piso-tis-krivontai-disekatommiria/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en-US&_x_tr_pto=wapp

mol

New subscription price 25% less

https://www.facebook.com/AxisBiotix/videos/25-off-previous-subscription-prices/1109584877674833/

Hmm

mol

Or here

https://find-and-update.company-information.service.gov.uk/company/12276227/officers

mol

Registered now effective from 31 May - so perhaps a month’s handover

https://find-and-update.company-information.service.gov.uk/company/09632164/filing-history

Though still not here

https://www.skinbiotherapeutics.com/investor-relations/board-of-directors/

Nor here

https://find-and-update.company-information.service.gov.uk/company/10549152/officers

mol

Cheers Friedman

mol

This isn’t updated either for new appointment

https://www.skinbiotherapeutics.com/investor-relations/board-of-directors/

If there was an overlap period - why not say so

mol

Lol

you and me both unless of course you let us know on the day you sell up and before market closes then there will be a buying frenzy

mol

Not far away

as i've written off my investment here in my mind rather than actually sold in my sipp (not a pretty picture as presented by my provider - though i don't consider their valuation method entirely reliable) albeit still at a considerable loss i may just hang on to the thought of

1. A company actually making a profit - not this year (2025) and probably not next (2026)

2. A deal re sweetbiotix sometime this year

3. anything else

and of course the enjoyment i derive from researching and posting what i find - albeit that's not what investing is about - tis when you have written off your investment in your mind

i don't post on companies i don't hold shares in btw

anyway just a thought re tock this evening - drivel some will note - and they may well be right - lol

bw all

mol

Struggling there and letting yourself down by responding - try to pick the proper time to jump in with your unabashed ramping

Martin Hunt, Chair of SkinBioTherapeutics said: "The Group's needs have changed substantially over the past 18 months with an active M&A strategy and the successful launch of the Croda Zenakine™ (SkinBiotix®) active ingredient. As a result of which, we identified a need to strengthen the Board and leadership team, especially the support required by Stuart to drive the Group's growth further. We have been very fortunate to have found two excellent new team members in Simon and Emily, and on behalf of the Board, we thank Manprit for his work as CFO and wish him well in the future.

"Simon has extensive corporate finance experience in M&A and the operational management following the deals to ensure they succeeded. He will provide Stuart with valuable support, especially in the day-to-day operations of the expanded Group, and will bring additional financial and investor relations experience to the Board.

"We are also delighted to have Emily returning to us as our Finance Director. Emily has a good knowledge of SkinBioTherapeutics' financial systems having worked in the finance team previously, and she is a very safe and experienced pair of hands having worked across multiple industries. We welcome her back in her new elevated role as Group FD."

mol

Re my last post

the beginning - go to thread view for the comments from start - if you are interested

and nothing better to do over weekend

mol

August 2024

So, Mol, essentially, you are a socialist Labour; be kind but hate anyone trying to build a business. Is your food, rent, car, transport FOC? I don't ask or persuade anyone to pay for our service; some of it is FOC. Being of petty mind as you are is your right, as is my right to call you out on your foolish rantings. You come across as a delicious neighbour peering over the fence and a better garden every time I venture a comment on here. It's childish, and most people know this, apart from the lemmings who voted for your posts. Six brain cells, at least. I don't think they have a critical thought between them.

Excuse me, over-the-top comments...You once claimed not to read "the drivel," we wrote. Make your mind up. As for the rest of your wants about SBTX...I will spare you my thoughts on the history lesson and the future. You're far too intelligent for me, especially with deep thought at your disposal. I'll take a dignified exit and leave you to your bitter self.

Just remember, your lot is supposed to be kind!

anyone who posts the above and then notes

Mol, with respect—which is rather more than you've extended to me, do try to keep up.

doesn't deserve anyone's respect

nevermind he was wrong on so many counts - wouldn't be the first time - lol

wasn't going to repost but then decided my last ever direct response to said poster

mol

Back in with 50000 shares seemingly in order to purely pledge

mol

I know you are aquae but thanks for the update on pricing - i wasn't aware of that - doesn't send a great demand signal

we - as shareholders - need more than you buying

bw

mol

Really not a very professional approach in updating a very simple thing

https://find-and-update.company-information.service.gov.uk/company/09632164/officers

https://find-and-update.company-information.service.gov.uk/company/10549152/officers

nevermind - probably only me that thinks these things are important and reflects badly on our company if not updated

mol