RE: Direct from Ashman late this afternoon11 Jun 2025 18:58
See the undernoted -relates to croda
Probiotic Bacteria
The invention relates to the use of probiotic bacteria. Probiotics are commonly defined as “live microorganisms which when administered in adequate amounts confer a health benefit on the host”. Studies in the gut have demonstrated the ability of probiotic bacteria to inhibit colonisation by pathogens through mechanisms including exclusion, competition and displacement of pathogen attachment to the host tissues. As used herein, the term “probiotic bacterium” may also refer to such bacteria when they are no longer alive, for example following inactivation by heat or radiation.
Lactobacillus rhamnosus
The invention particularly relates to probiotic bacteria of the species Lactobacillus rhamnosus. Such bacteria were originally considered a subspecies of Lactobacillus casei, but later genetic research found it to be a species of its own. A number of L. rhamnosus strains are known. For example strains I-1720 (Pasteur Collection Nationale de Cultures de Microorganismes), AC413, GR-1 (Karlsson et al., BMC microbiology 2012, 12:15), JB-1 (Bravo et al., PNAS 2011, 108(38) 16050-16055), GG and Lc705 (Savijok et al., J. Proteome Res. 2011 10(8): 3460-3473). Other strains of L. rhamnosus may be readily isolated. Optionally, some embodiments of the present invention do not include the use of Lactobacillus rhamnosus strain LB21.
In particular, the invention relates to L. rhamnosus GG. L. rhamnosus GG (also referred to herein as LGG) is deposited at ATCC (American Tissue Culture Collection) under accession number ATCC 53103. L. rhamnosus GG was isolated in 1983 from the intestinal tract of a healthy human being by Gorbach and Goldin,
Lactobacillus reuteri
The invention also relates to Lactobacillus reuteri strains. L. reuteri is a gram-positive bacterium that naturally inhabits the gut of mammals and birds. A number of L. reuteri strains are known. For example, DSM 17938 and ATCC deposits 23272, 53608, 53609 and 55148 and 55739. L. reuteri strains are described in, for example, U.S. Pat. No. 6,872,565, and U.S. Pat. No. 7,517,681. Other strains of L. reuteri may be readily isolated.
A particularly preferred L. reuteri strain according to the invention is deposited at ATCC under accession number ATCC 55730, described in U.S. Pat. No. 5,837,238.
Bifidobacterium longum
The invention also relates to Bifidobacterium longum strains. Bifidobacterium longum is a species of gram-positive bacterium found in the intestines of infant humans. A number of Bifidobacterium longum strains are known. For example, ATCC deposits 15708, 55816, 55818, 15707, 35183, and 51870. Other strains of Bifidobacterium longum may be readily isolated.
A particularly preferred Bifidobacterium longum strain according to the invention is Bifidobacterium longum reuter. In some embodiments the Bifidobacterium longum reuter is deposited at ATCC under accession number ATCC 5187
https://patents.justia.co
Sign In
Follow the stocks
