Member Info for Matml74

29th October was the first day we had automated trades.

gkb47, It moved over around the time of the placing. I did post a message about it at the time. I will go back through my posts to find exact date.

Joey, Ignore the word sell. These are not all sells. LSE is naming them sells but is comparing the trade price from yesterday to the spread price at close today. Hope that makes sense. Only way you work out exactly what these trades were is go back and compare them to yesterdays spread at the time they were made. I did this with the 100k trade in that lot and it was a buy.

Bruce, todays late reported below. Spreads are incorrect.

02-Dec-20 08:03:04 78.00 43,118 Sell* 81.00 83.50 33.63k O
02-Dec-20 08:08:37 75.266 41,083 Sell* 81.00 83.50 30.92k O
02-Dec-20 08:50:29 78.50 38,210 Sell* 81.00 83.50 29.99k O
02-Dec-20 14:39:57 79.1208 30,000 Sell* 81.00 83.50 23.74k O
02-Dec-20 08:26:13 78.4925 30,000 Sell* 81.00 83.50 23.55k O
02-Dec-20 08:52:53 79.90 37,538 Sell* 81.00 83.50 29.99k O
02-Dec-20 08:07:21 74.00 70,000 Sell* 81.00 83.50 51.80k O
02-Dec-20 16:10:58 79.3111 35,000 Sell* 81.00 83.50 27.76k O
02-Dec-20 13:16:32 79.00 54,760 Sell* 81.00 83.50 43.26k O
02-Dec-20 16:15:56 79.78 40,000 Sell* 81.00 83.50 31.91k O
02-Dec-20 13:31:43 78.7268 74,000 Sell* 81.00 83.50 58.26k O
02-Dec-20 14:44:19 79.35 30,000 Sell* 81.00 83.50 23.81k O
02-Dec-20 08:10:22 76.4999 30,000 Sell* 81.00 83.50 22.95k O
02-Dec-20 16:15:42 79.615 29,000 Sell* 81.00 83.50 23.09k O
02-Dec-20 08:17:21 79.50 30,177 Sell* 81.00 83.50 23.99k O
02-Dec-20 09:27:16 79.40 50,000 Sell* 81.00 83.50 39.70k O
02-Dec-20 08:00:31 81.77 27,360 Sell* 81.00 83.50 22.37k O
02-Dec-20 13:50:16 79.8055 100,000 Sell* 81.00 83.50 79.81k O
02-Dec-20 08:12:16 77.70 50,000 Sell* 81.00 83.50 38.85k O
02-Dec-20 11:41:27 80.10 50,000 Sell* 81.00 83.50 40.05k O
02-Dec-20 08:06:02 76.00 55,053 Sell* 81.00 83.50 41.84k O
02-Dec-20 13:51:47 79.00 30,000 Sell* 81.00 83.50 23.70k O

I was monitoring the after hours trades for a fair while. The 'real' spreads at present are so tight it is hard to work out what is a sell or buy and has been like this for a few weeks now. I have now just been focussing on the really large trades (100,000k plus shares). Yesterday's 100k trade, reported tonight was a buy. Spread at the time was 78.75 - 79.39 and that went through at 79.8055. Most of these large trades have been buys of the past couple of weeks. There is someone out there not afraid to go big on this share.

Donnie, There are a fair few people here went through the same thing earlier in the year. People were complaining then of the drop from 70p to 33p. No news flow, why are the results taking so long etc etc etc. Most expected the results in COPD results in June. We got them in September. If lack of news flow is getting on your nerves sell up and take the loss, because as long as I have been invested in this share RM only drops an RNS when he has something significant to say. Otherwise it is deathly silence but you can rest assured they are just getting on with the job at hand, which is a pretty significant one atm.

TL, I think once the phase 3 trial is up and running we could get a left field RNS at any point in time that could propel the share price. I think we will see an interim analysis and this will be the moment where hopefully an EUA will be upon us.

There was an rns for start of phase 2 31st March.

“The first patient has been dosed at the initial trial site (University Hospital Southampton NHS Foundation Trust). Synairgen has initiated a further six trial sites which are expected to start dosing in the coming days.”

There will be an rns for start of phase 3.

*typo Q4 2020 not 2021.

There is no delay yet. The trial should be considered as delayed if we haven't started by the end of 2021. Everything written about the start date says Q4 2020. We all want it to have started yesterday but this trial is a big logistical challenge and there is no point charging off at the start if it bites you in the arse at some point in the future.

Jonathan, If we get anywhere near the 80% in the phase 3 trial that was reported in the phase 2 trial the world will take notice. It would be the most effective COVID 19 treatment by a country mile. People think the market is shrinking. I disagree completely. There is going to be a huge market for this drug because of the trillions of dollars this pandemic has cost the world. No government will ever risk that happening again.

BTB,

We have nearly completed a phase 2 for COPD. 11 more patients to recruit. The trial is on hold but will complete next year. I think successful phase 3 alongside COPD data will go a long way towards providing SNG001 up as a board based antiviral. We will have approval for COVID and whilst there maybe still some work to do to gain approvals for COPD it should be a much easier and faster path to approval for that as well.

Why have none of these vaccines been put through human challenge trials? Surely this would put to bed any questions people had and would reveal true efficacy? Judging efficacy in an unrealistic real world environment (mask wearing/social distancing) surely skews the data. The UK government spent £33m to support challenge studies on covid. Why have these vaccines not been tested in this way or did they just decide to **** this money up the wall as well? Of course there are some ethical issues but surely this would convince larger proportions of the population to accept the vaccine's approval.

"investors won’t want to tie up their money for months on end if they know nothing major is happening"

You are talking about traders, they will always come and go. Investors here will be looking to the end game aka buyout and will let their capital sit here until that eventuates.

HC, That is a good buy.

You can see some information on age profiles of the vaccines here.

https://www.biopharma-reporter.com/Article/2020/11/23/COVID-19-vaccine-hope-for-older-adults-AstraZeneca-Pfizer-Moderna-trial-data

Pfizer had 41% of subjects between 55 and 85. However there is no more detail than that and also no detail on how many in this group caught the virus. Wish they would just publish the data FFS.

Yes Millie that is a tragic situation that should never have happened. Lets hope that nothing similar happens with the upcoming vaccination programs.

Hanyma,

To be fair this is a slightly different situation. A new vaccine produced in record time that has never been used in humans before. People have every right to ask some questions about it. I am far from antivax with my children having had all their vaccinations whist I have had yellow fever and several others as well.

You are right though we should all have faith in the MHRA. They do a great job in protecting us all. All I want to see is that data published for all to review.

Also your presumption that everyone here has no medical or scientific knowledge and understanding is ignorant.

Great news that there is now a vaccine approved. Hopefully this starts the world on the road back to recovery. However, personally I still have my doubts on this vaccine. The narrative is all too contrived. Fancy the vaccine being approved on the day lockdown ends. Yet to see any data published or a "peer review" which everyone held up as being hugely important in providing credibility with our phase 2 data. It is only going to take one issue with the vaccination program and the press will be all over this government.

Share price has held up well. Seems those that thought they were going to make a quick killing have left. I am really excited by where this company could be this time next year.

Our man Sir S Holgate did try and prep the government whilst chairing the Preparing for winter report. I have been through the report previously and there is a section on treatments in there which I posted previously on the BB. Most of the recommendations in that report never came to fruition. Government was more excited about eat out to help out in the summer than any preparation for winter covid 2nd wave.

https://acmedsci.ac.uk/more/news/prepare-now-for-a-winter-covid-19-peak-warns-academy-of-medical-sciences

I don't think fund managers give two ****s about PI's myself.

@beforegolf

Agree we all have different frustrations in any stock. My frustration here is mainly around the fact that there was hope back in July that sng001 would be saving lives this winter. That it is not, I currently put down to lack of government support (ie they could have easily funded the production of many doses of sng001), but equally it could be due to the company as well i.e.not having adequate partners in place to ramp up required stock required for winter. This is something the company should be communicating to it's shareholders. How much stock is there currently?

GL and I am sure true value will come..... eventually!