Member Info for Matml74

Seriously mumbo. Read the RNS"s. It is all in there.

Clinigen = MAP clearly stated.
Paraxel = Phase 3 clearly stated.

Why someone believe a post on a BB over what is stated in the RNS's is beyond me.

Thanks for this. Plenty of information in that which is what I am after. Can't see why the MHRA could not have produced a similar document for the public and media to look at.

Main take home from that is this line appears a lot....... "and at present it is not possible to assess whether the vaccine will have an impact"

There is a hell of a lot buying going on at the moment. 10 and 20k prints going through without delay which is unusual. Very strange the volume atm based on no news. Let time we had this kind of volume was 16th November.

Agreed. I really can't see the point in calling them up. Let them do their job. If you are unhappy with the job they are doing then sell up.

This sounds like bull**** to me. Clinigen have nothing to do with the phase three trial. They are involved in MAP.

Paraxel are running the phase 3.

If they are from this site then no chance they are correct. It is very difficult to know what is a sell or buy when in auction which we were into close yesterday.

On the positive side L2 looks like an open around 100p and plenty of offers on the bid around this level.

Well done @beforegolf. Averaging down has got me out of some rubbish shares previously with b/e or a small loss. With SNG you are in a good position now to bag multiple times when this flies. I added another 45k shares in the 80's . Am torn between a ST trade with these or holding until phase 3 results as I am in quite heavy here. Will depend on first bit of news I guess.

Even at todays price it is still worth topping up. We basically opened up at this level on the 20th July. This share moves fast and any kind of positive rns will see it back over £2.

Whole world EUA

LOL. This is the best theory I have seen for the rise. Can see why Sue was unhappy with the call now!

Oak, It was in auction at the end of the day and the bid was at 105. UT is 98.5 though. HL always shows the bid as the closing pice on my account.

" If the trial replicated a 79% improvement to placebo in the drug arm would that be high enough to satisfy emergency use?."

If its not then we might as well sell up now. As I posted yesterday anything at or above what dexamethasone can achieve (20% reduction death on oxygen/35% on ventilators) should be enough to get EUA. It obviously depends on what stage of covid they are aiming treatment at but at this stage it looks like anyone presenting to hospital and in need of oxygen would get a dose of SNG001.

Hi Doc,

I think this paper sums up the difficulties. I posted it yesterday but you may have missed it.

https://science.sciencemag.org/content/370/6518/811

Interestingly their first lines of the abstract - "Humans are infected by several seasonal and cross-reacting coronaviruses. None provokes fully protective immunity, and repeat infections are the norm. Vaccines tend to be less efficient than natural infections at provoking immunity, and there are risks of adverse cross-reactions."

and more importantly - "The model outcomes show that our imperfect knowledge about the imperfect coronavirus immune landscape can give rise to diverging scenarios ranging from recurring severe epidemics to elimination. It is critical that we accurately characterize immune responses to SARS-CoV-2 for translation into managing disease control.

I really hope the vaccines produce a robust immune response is more akin to MERS/SARS situation. If so then the vaccines really will go a long way to halting this pandemic. Unfortunately we just don't know if this is the case yet.

Good summary here.

https://www.sciencemag.org/news/2020/11/more-people-are-getting-covid-19-twice-suggesting-immunity-wanes-quickly-some

The truth of the matter is no-one really knows the extent of immunity yet and as with all disease, immunity can and will vary between individuals.

No worries smokie. Good luck with your investment. Hopefully some news this week to get the sp some positive momentum.

Great news CW for you and your family. Great also to hear that the trial sounds like it is being run in a very professional manner.

HC, An interesting paper here on immunity. A lot of it is hard going both some interesting points none the less.

https://science.sciencemag.org/content/370/6518/811

A lot still to be understood. Basically these guys have said it is impossible to understand/model how this pandemic will pan out because so little is currently known about natural immune response, let alone vaccine immune response. The market however seems to have nailed it and its all over by Easter.

Smokie, I understand what you are saying. I don’t think anyone here thinks that we should bypass any of the normal checks that any drug should go through.

What I and I suspect many others find frustrating with the process is that interferon beta is not new. It has been used in MS for a long time. Even nebulised interferon is not completely new. Effectively been tested in 3 phase 2 trials since 2015. Then you find yourself in the middle of a pandemic, and interferon beta is found to reduce the impact of covid by 80%. It appears to me to be a no brainier to get this out there to save peoples lives now.

...... and then a brand new vaccine comes along, never been used in humans, only injected into about 15000 people and with very early stage efficacy data, which while very high, is still only early stage, somehow gets to pass through regulators in basically a matter of days.

It really leaves me scratching my head. But what really frustrates me is that not one journalist out there covering this pandemic has once bought up the case for using interferon despite the large amounts of science showing that covid is overriding the interferon defence mechanism. Are they really all that thick?

Smokie, SNG001 was first tested in people in 2015 in asthma trials. Safety data is pretty extensive. Not sure that comparison is fair.

Agree Glen. This is definitely a share to hold to see how the endgame unfolds.