Member Info for LovableLumax

So when the CEO and other scientists say AVA6000 does not need it half life extended (as the 24 hour biopsies show) they are lying? Is that what you're saying? If so, how much dox 24 hours after dosing do you expect in the tumours?

FYI - Initial Distribution Phase:

Doxorubicin is quickly distributed into tissues with a half-life of about 5 minutes.

Elimination Phases:

The drug is eliminated through a triphasic process. The initial half-lives are 12 minutes and 3.3 hours, and the terminal half-life is typically 30 hours, though it can range from 20 to 48 hours

If data throws up an indication with a quicker route to market as no SOC then it would be stupid to doggedly stick to the original plan. Simple really.

All this guff about being cashed up is just that, guff. Nearly £900k of the £1.5m raised was to pay off staff etc and they need to massively up sales to have 12 months runway as per the RNS. If they don't to well they'll die a death and the partner will run off with their US and likely other clients. Remember their cost base is still £3m a year.

The net proceeds receivable by the Company pursuant to the Placing, being a minimum of approximately £1.5 million, together with the Company's existing cash resources, will be used to fund approximately £0.87 million of one-off costs associated with the cost cutting measures set out above, as well as for general working capital purposes to pursue the revised operating strategy.

 

The Board considers that the net proceeds of the placing, together with Mirriad's existing cash balance, payment of the accrued R&D tax credit for the year ended 31 December 2024 in line with the usual timetable, and subject to receipt of the £0.2 million JV Contribution, will provide the Company with a cash runway of not less than 12 months. This assumes that Mirriad is able to achieve cash receipts from sales of not less than £1.2 million in the 12 months ending May 2026.

That said it could well be Rembrand as the JV which IMO is a poor reflection on MIRI and they could only attract a minnow rather than a major player and they still got their pants pulled down. A major gets involved and saves the day you expect to bend over but little old Rembrand that's only been around a couple of years. Ouch.

If Rembrand is mopping up shares who is selling below the raise? Seems odd.

Defo recommend ignoring Phevs' LinkedIn nonsense. I mean a while ago becasue someone who worked at a finance co liked a post of the old CEO's Phevs was sure Mirriad with feck all revenue and massively loss making would be legible for 'invoice financing'. What a joke.

Anyway, I am sure there is money to be made here short term given the crazy share price and market cap but a fair few sells below the disastrous raise price (which was 1/10th of what I predicted in January and got slated for).

Bella, you implied TR1s only needed to be issued if the reduction in % is due to sales rather than through dilution which isn't true. They both need TR1s. It's the responsibility of the seller to inform the PLC when they've reduced and crossed a threshold and for the PLC to then issue TR1s.

If the PLC issues more shares it will know what this means for its holders and whether thresholds have been crossed as should the holder and TR1s will be issued. I have no doubt the shareholders have informed Avacta of their sells which is why they updated the website but failed to issue TR1s (both sells and now more recently buys).

Immaterial whether the reduction in % is due to dilution or sale TR1s are still needed. Hence why after raises most PLCs will issue TR1s with revised percentages

It doens't matter. If a co goes below a threshold (3%, 4% etc) TR1s have to be issued.

Thing is Avacta didn't issue TR1s when there were sells either and they were informed given they updates the website. Poor all over.

If there are buys there are sells and if there are buys below 0.01p then there are sells below too which was why I didn't understand what Mannan was saying.

Mannan where are all these shares coming from at below 0.01p if no one is selling at a loss?

CFO is so poor, reading from a script

Chris a super presenter but the CFO a shocker. Interested to see the rem report when it's published. Hopefully we're saving a fair whack and his salary modest.

CFO was woeful

It's a wider audience than long suffering holders

Recruitment for the cohort is progressing as planned but the expense of analysing of the data has been put on hold for the time being in order to preserve funds.

As part of the trial they need to analyse the data for patient welfare.

LOTM I lost a fair whack here but as I said before I shorted it before the 1.25p raise and made a decent bit back.

I don’t wish you ill or the co but while you were telling people to buy at 2p last year I was warning them to sell and yon tried to discredit so people would listen to you and buy.

Having got burnt i didn’t want others to and you apologised last year after the 1.25p raise but you learnt nothing and continued to buy and egg others on even criticising some who sold recently for 0.4p

Anyway, I'm glad some listened to me and saved their cash.

Yep health and happiness is key. Hear hear to that. I hope you've learnt and best of luck.

Apologies I wasn't referring to you.

As I said I think money can be made here short term. I don't think they have a viable business going forward certainly to be listed which isn't cheap. The JV will I assume build relationships with MIRI's partners and I assume MIRI won't do well enough to keep a listing and will die a death within 9 months or so and the JV partner will simply take their clients. I'm guessing. Anyway, best of luck

I don't wanna dominate the board so will leave you to it as it looks good for a trade. So funny these Jonny come latelys getting all hot and bothered when someone gives a different view.

Office you're clueless. You can look back and see my warnings before the raise and over the last 12 months so get back in your box.